Modulatory effects of swimming exercise against malathion induced neurotoxicity in male and female rats

Salama, Ola A.; Attia, Maha M.; Abdel-Razek, Mohamed A.S.

doi:10.1016/j.pestbp.2019.01.014

Cited by 12 publications

(5 citation statements)

References 46 publications

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“…Caspase-3 has an important role in the apoptotic pathway and is widely used as an apoptotic marker in many studies [48][49][50][51]. It has been reported that MLT treatment increases apoptotic proteins in the brain such as Bax, Bak and caspase-3 [52,53]. In the present study, it was observed that MLT could trigger the apoptotic process by up-regulating caspase-3 expression in lung tissue.…”

Section: Discussionsupporting

confidence: 54%

Evaluation of the Levels of Metalloproteinases as well as Markers of Oxidative Stress and Apoptosis in Lung Tissues After Malathion and Rutin Administrations to Rats

Gür

Kandemir

2022

Türk Doğa Ve Fen Dergisi

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Malathion (MLT) is an important environmental pollutant in the organophosphate class. Rutin (RUT), on the other hand, is one of the flavonoid family members whose effectiveness against various toxic agents has been extensively studied. In the present study, the effects of MLT and RUT treatments on oxidative stress, apoptosis and metalloproteinases in lung tissues of rats were investigated. In the study, MDA, GSH, Nrf2, HO-1, MMP2, MMP9 and caspase-3 levels in lung tissues were analyzed by biochemical or RT-PCR method after rats received MLT and/or RUT treatment for 28 days. The data showed that MLT-induced MDA levels decreased after RUT treatment. In addition, it was determined that Nrf2 and HO-1 mRNA transcript levels and GSH levels suppressed by MLT approached the control group levels after RUT treatment. MLT up-regulated the expression of metalloproteinases (MMP2 and MMP9) in lung tissues, while RUT down-regulated the expression of these genes. In addition, it was observed that MLT triggered caspase-3 expression, while RUT exerted an anti-apoptotic effect by suppressing caspase-3. As a result, it was determined that while MLT showed toxic effects in the lung tissues of rats through oxidative stress, apoptosis and metalloproteinases, RUT could alleviate these toxic effects.

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Section: Discussionsupporting

confidence: 54%

Evaluation of the Levels of Metalloproteinases as well as Markers of Oxidative Stress and Apoptosis in Lung Tissues After Malathion and Rutin Administrations to Rats

Gür

Kandemir

2022

Türk Doğa Ve Fen Dergisi

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“…Both, mitochondrial disturbances and DNA damage may lead to the activation of apoptotic pathways. MAL treatment was found to increase proapoptotic and apoptotic proteins in the brain (Brocardo et al 2005), such as Bax, Bak (dos Santos et al 2016), and caspase-3 (Varol et al 2015;Salama et al 2019), and reduce antiapoptotic proteins, such as Bcl-2 and p-Akt (Venkatesan et al 2017). Imbalance of proapoptotic and antiapoptotic proteins stimulates the mitochondrial release of cytochrome c and induction of caspase-dependent DNA fragmentation.…”

Section: Mechanisms Of Malathion-induced Neurotoxicitymentioning

confidence: 99%

Organophosphate toxicity: updates of malathion potential toxic effects in mammals and potential treatments

Badr

2020

Environ Sci Pollut Res

102

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Organophosphorus insecticides toxicity is still considered a major global health problem. Malathion is one of the most commonly used organophosphates nowadays, as being considered to possess relatively low toxicity compared with other organophosphates. However, widespread use may lead to excessive exposure from multiple sources. Mechanisms of MAL toxicity include inhibition of acetylcholinesterase enzyme, change of oxidants/antioxidants balance, DNA damage, and facilitation of apoptotic cell damage. Exposure to malathion has been associated with different toxicities that nearly affect every single organ in our bodies, with CNS toxicity being the most well documented. Malathion toxic effects on liver, kidney, testis, ovaries, lung, pancreas, and blood were also reported. Moreover, malathion was considered as a genotoxic and carcinogenic chemical compound. Evidence exists for adverse effects associated with prenatal and postnatal exposure in both animals and humans. This review summarizes the toxic data available about malathion in mammals and discusses new potential therapeutic modalities, with the aim to highlight the importance of increasing awareness about its potential risk and reevaluation of the allowed daily exposure level.

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“…Malathion has been shown to reduce the levels of several antiapoptotic proteins, such as phosphorylated AKT and BCL-2. Malathion induced apoptosis by increasing the amount of Bax/Bcl2 ratio, and caspase 3, in the brain is noteworthy [ 6 , 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

Potential protective effects of red grape seed extract in a rat model of malathion-induced neurotoxicity

Saadh

2023

Vet World

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Background and Aim: Exposure to pesticide mixtures used in agricultural practice poses a grave risk to non-target animals. This study aimed to determine whether red grape seed extract (RGSE, which is 95% bioflavonoids and equal to 12,000 mg of fresh red grape seed, and 150 mg of vitamin C) alleviated the changes in brain-derived neurotrophic factor (BDNF) level, acetylcholinesterase activity, oxidative stress, and apoptosis induced by orally administered malathion in a rat model of malathion-induced neurotoxicity. Materials and Methods: Thirty-two adult male Wistar albino rats were divided into four groups and exposed to malathion with or without 4 weeks of RGSE treatment, treated with RGSE alone, or left untreated as controls. The animals were euthanized 24 h after last treatment. Brain samples were collected to measure acetylcholinesterase, superoxide dismutase (SOD), and caspase 3 activity, total antioxidant capacity (TAC), and BDNF levels. Results: Malathion significantly reduced acetylcholinesterase and SOD activity and TAC and significantly increased caspase 3 activity. In comparison, acetylcholinesterase and SOC activity, BDNF level, and TAC were improved and caspase 3 activity was decreased in the malathion-RGSE group, indicating that RGSE corrected the alterations detected in these biochemical parameters. Conclusion: Oxidative stress and apoptosis in the brains of rats exposed to oral malathion were substantially controlled by RGSE treatment.

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Modulatory effects of swimming exercise against malathion induced neurotoxicity in male and female rats

Cited by 12 publications

References 46 publications

Evaluation of the Levels of Metalloproteinases as well as Markers of Oxidative Stress and Apoptosis in Lung Tissues After Malathion and Rutin Administrations to Rats

Evaluation of the Levels of Metalloproteinases as well as Markers of Oxidative Stress and Apoptosis in Lung Tissues After Malathion and Rutin Administrations to Rats

Organophosphate toxicity: updates of malathion potential toxic effects in mammals and potential treatments

Potential protective effects of red grape seed extract in a rat model of malathion-induced neurotoxicity

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