Modulatory effects of snuff, retinoic acid, and<i>ß</i>‐carotene on DMBA‐induced hamster cheek pouch carcinogenesis in relation to keratin expression

Gijare, P. S.; Rao, K. Venkata; Bhide, S. V.

doi:10.1080/01635589009514101

Cited by 16 publications

(5 citation statements)

References 22 publications

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“…[75] However, in another study, forestomach tumors developed the following application of snuff to the hamster cheek pouch mucosa. [76] Skin papillomas were induced following application of black or brown masheri extract to the back skin of nude Swiss mice, [63] although topical application of a black masheri extract did not induce skin tumors in Swiss mice. Similar treatment, however, resulted in skin papilloma development in hairless Swiss mice and the extract promoted skin papilloma formation in DMBA initiated Swiss mice.…”

Section: Carcinogenicity Of Sltmentioning

confidence: 99%

Chemistry and toxicology of smokeless tobacco

Ra¹

2012

Indian J Cancer

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In most parts of the world, tobacco is used for smoking, whereas, in India, tobacco is used for smoking as well as in diverse smokeless forms. Absorption of toxic and carcinogenic chemicals in tobacco and other ingredients added to various products are causally associated with several non-communicable diseases including cancer, especially oral cancer, which is the leading cancer among men and the third most common cancer among women in India. This article highlights the toxicity, mutagenecity and carcinogenic effects of hazardous chemicals present in smokeless tobacco products. This endeavor was based on the extensive review of literature from various sources. The SLT products have influence on cellular metabolism, ability to cause DNA damage, and cancer in experimental animals. It is, therefore, essential to consider the collective role of chemical constituents of SLT products in the causation of adverse effect on human health.

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Section: Carcinogenicity Of Sltmentioning

confidence: 99%

Chemistry and toxicology of smokeless tobacco

Ra¹

2012

Indian J Cancer

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“…Ten studies on OC showed that vitamin A supplementation, oral or injected, significantly reduced the lesion size progression and tumour count, with signs of total inhibition of carcinogenesis in the hamster cheek pouch model [37]. Notably, one study reported that topical vitamin A treatment resulted in oral leukoplakia progressing to OSCC in the hamster buccal pouch model [38].…”

Section: In Vivo Animal Studiesmentioning

confidence: 99%

The Role of Vitamins in Oral Potentially Malignant Disorders and Oral Cancer: A Systematic Review

See,

Liu,

Canfora

et al. 2023

JPM

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Background: Micronutrients are vital for general and oral health, and their potential anti-cancer properties are documented. We explore beneficial vitamins for oral potentially malignant disorders (OPMDs) and oral cancer (OC), assessing the therapeutic impacts of essential vitamin supplementation. Methods: We systematically review evidence on vitamin supplementation’s therapeutic effects for OPMDs and OC. Relevant studies were identified through comprehensive searches of MEDLINE, Evidence-Based Medicine, and Web of Science until 16 May 2023. All studies underwent risk of bias using criteria modified from the Office of Health Assessment and Translation (OHAT) tool. Results: We analysed 80 papers. Vitamin K, studied in vitro, shows promising therapeutic potential. Vitamin C, investigated in vivo (animals and humans), demonstrated mixed animal results and generally positive human trial effects. Vitamin A’s efficacy varied, with positive monotherapy or adjunct effects. Vitamins B and D showed therapeutic benefits. Oral cancer research was extensive, with a focus on oral lichen planus and oral leukoplakia among the 11 OPMDs. All bias levels were reported in ‘selective reporting’ and ‘performance’, except for “definitely high” in the ‘selection’, ‘detection’, and ‘attrition/exclusion’ domains. Conclusions: Evidence of vitamin interventions for OPMDs and OC ranges from mixed to promising. Standardizing the study design and outcomes would enhance future research.

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“…Outros estudos têm evidenciado ação protetora do β-caroteno contra carcinogênese conduzida em animais, em associação a determinados nutrientes. Nesse sentido, ALABASTER et al (1995) CHEN et al (1993) NISHINO (1995) SUDA et al (1986) GIJARE et al (1990) MORENO et al (1991e 1995a SARKAR et al…”

Section: Estudos Em Animais (In Vivo)unclassified

Beta - caroteno e câncer

Naves

1998

Rev. Nutr.

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Há mais de vinte anos tem-se pesquisado sobre a relação entre β-caroteno e câncer. Inúmeros trabalhos têm tentado esclarecer a hipótese, formulada a partir de achados epidemiológicos e experimentais, de que o carotenóide poderia agir como anticarcinogênico de origem alimentar. Estudos epidemiológicos observacionais, tipo caso-controle e coorte, sugerem que o consumo elevado de frutas e vegetais ricos em β-caroteno reduz o risco de câncer, especialmente de pulmão. Estudos de intervenção em humanos, administrando doses farmacológicas crônicas a milhares de indivíduos, têm demonstrado resultados contraditórios. Pesquisas em animais experimentais e em cultura de células apontam o carotenóide como quimiopreventivo, agindo sobretudo como retinóides, através de conversão metabólica extra-intestinal e como antioxidante de membrana. Conclui-se que o β-caroteno pode proteger contra o câncer, quando suplementado em doses fisiológicas, isto é, cerca de 4 a 6mg/dia. Doses farmacológicas crônicas não estão recomendadas para indivíduos saudáveis e particularmente para tabagistas.

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Modulatory effects of snuff, retinoic acid, andß‐carotene on DMBA‐induced hamster cheek pouch carcinogenesis in relation to keratin expression

Cited by 16 publications

References 22 publications

Chemistry and toxicology of smokeless tobacco

Chemistry and toxicology of smokeless tobacco

The Role of Vitamins in Oral Potentially Malignant Disorders and Oral Cancer: A Systematic Review

Beta - caroteno e câncer

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