Modulatory effects of Punica granatum L juice against 2115 MHz (3G) radiation-induced reproductive toxicity in male Wistar rat

Gautam, Rahul; Priyadarshini, Eepsita; Nirala, Jay Prakash; Meena, Ramovatar; Rajamani, Paulraj

doi:10.1007/s11356-021-14378-4

Cited by 6 publications

(2 citation statements)

References 44 publications

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“…LA relieves spermatogenesis disorder caused by PFOA. Sperm count is an important indicator of reproductive toxicology, which accurately reflects the degree of reproductive damage to animals caused by toxicants (15,16). The sperm counts of rats were reduced after PFOA intoxication compared with the counts of rats in control and LA groups.…”

Section: Resultsmentioning

confidence: 99%

Efficacy and mechanism of lipoic acid in the treatment of reproductive injury caused by perfluorooctanoic acid

et al. 2023

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Environmental pollutants, including perfluorooctanoic acid (PFOA), cause severe reproductive damage to humans and animals. Lipoic acid (LA) is a strong antioxidant that alleviates the oxidative damage caused by heavy metals, environmental toxicants, chemical poisons, etc. Therefore, the present study investigated the curative effect and mechanism of LA in treating spermatogenesis dysfunction caused by PFOA. A rat reproductive injury model was established by gavage of PFOA for consecutive 30 days and then rats were treated with different doses of LA for 42 days. The effects were assessed by ELISA, western blotting, H&E staining and immunofluorescence staining. The results demonstrated that LA had ameliorating effects on PFOA-induced reproductive injury in rats, it increased the sperm counts, and the levels of serum succinate dehydrogenase, lactate dehydrogenase, glutathione peroxidase and superoxide dismutase returned to normal levels following LA treatment. In addition, LA promoted the expression of estradiol, reduced the expression of serum sex hormones, such as follicle-stimulating hormone, androgen receptor (AR) and malondialdehyde in the testes, and restored the structure of seminiferous tubules. Its therapeutic mechanisms include regulating the testicular oxidative stress pathway and hypothalamic-pituitary-testis axis.

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Section: Resultsmentioning

confidence: 99%

Efficacy and mechanism of lipoic acid in the treatment of reproductive injury caused by perfluorooctanoic acid

et al. 2023

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“…and stimulating the development of the testicles and spermatogenesis in young Wistar rats17 . Sengupta et al, 2018 reported W. somnifera increases antioxidant levels, improves sperm quality (concentration and motility), lowers seminal LPO levels, stress and serum cortisol levels, and reduces the generation of ROS18 .…”

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confidence: 99%

A Systemic Review on Use of Medicinal Plant for Management of Male Infertility

Thakur,

Sahu,

Kaur

et al. 2024

JNR

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A recent issue with current society is the fall in male infertility. In 50% of instances, couple infertility is caused by the failure in spermatogenesis of the male partner. The male reproductive system is impacted by a variety of factors that lead to infertility, including genitourinary tract infections, endocrine abnormalities, immunological factors, lifestyle, stress, and drug-related damage. There are medications and therapies for male infertility, but they are not very effective, have harmful side effects, and are contraindicated. Plants are among the greatest natural cures for illnesses since they have very few side effects and include a variety of phytoconstituents from different chemical classes. Depending on their concentration, plant bioactive such as flavonoids, polyphenols, glycosides, alkaloids, and terpenoids might have a variable effect on sperm quality - either positively or adversely. These compounds have been suggested as organic reactive oxygen species scavengers for the treatment of male infertility. This review makes an effort to compile the available information and offer perspectives for upcoming investigations on how plants affect male gonads. This review summarizes the most recent research on the use of phytoconstituents to increase testosterone production, support healthy spermatogenesis, and prevent age-related degenerative illnesses linked to low levels of testosterone. This review includes information on about 45 herbal plants that have been published in several papers. The articles have several headings, including plant taxonomy, bioactive components, impacts on fertility, and medical applications. This review provides information on the applications of natural sources for male fertility enhancement and their potential mechanisms of action.

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