Modulatory effects of perindopril on cisplatin-induced nephrotoxicity in mice: Implication of inflammatory cytokines and caspase-3 mediated apoptosis

Aljuhani, Naif; Ismail, Raed S.; El‐Awady, Mohammed S.; Hassan, Mostafa I.

doi:10.2478/acph-2020-0033

Cited by 10 publications

(5 citation statements)

References 31 publications

(36 reference statements)

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“…The experimental model used in this work, 16 mimics the chemotherapy treatment cycles, describing cardiac and vascular alterations with this administration pattern. The present study shows a renal hypertrophy after cisplatin treatments, confirming data described by other authors after single doses, 35–41 or cycles 42 cisplatin treatments. Therefore, the present experimental model would be valid for the study of mechanisms involved in cardio‐renal complications after chronic treatment with cisplatin.…”

Section: Discussionsupporting

confidence: 93%

Cisplatin cycles treatment sustains cardiovascular and renal damage involving TLR4 and NLRP3 pathways

González

Gómez-Heras

Franco-Rodríguez

et al. 2023

Pharmacology Res & Perspec

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Cisplatin is clinically proven to combat different cancers, including sarcomas, soft tissue cancers, bones, muscles, and blood. However, renal and cardiovascular toxicities are important limitations in cisplatin therapeutical use. Immunoinflammation could be key factor in cisplatin‐induced toxicity. The aim of the present study was to evaluate the activation of the inflammatory TLR4/NLRP3 pathway as a common mechanism for cardiovascular and renal cisplatin's cycles treatment toxicity. Adult male Wistar rats were treated with saline, cisplatin 2 mg/kg or cisplatin 3 mg/kg (intraperitoneally once a week, for five experimental weeks). After treatments, plasma, cardiac, vascular, and renal tissues were collected. Plasma malondialdehyde (MDA) and inflammatory cytokines were determined. TLR4, MyD88, NF‐κβ p65, NLRP3, and procaspase‐1 tissue expressions were also analyzed. Cisplatin treatment induced a dose‐dependent increase in plasma MDA and IL‐18. In cardiovascular system, an increase in NLRP3 and in cleaved caspase‐1 were observed in cardiac tissue and a moderate increase in TLR4, MyD88 appeared in mesenteric artery. In kidney, a significant dose‐dependent increase in TLR4, MyD88 and NLRP3 and cleaved caspase 1 expressions were observed after cisplatin treatments. In conclusion, cisplatin cycles provoke a low grade pro‐inflammatory systemic state. Kidney was more sensitive than cardiovascular tissues to this pro‐inflammatory state. TLR4 and NLRP3 are key pathways involved in renal tissue damage, NLRP3 is the main pathway involved in cardiac toxicity and TLR4 pathway in resistance vessel toxicity.

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Section: Discussionsupporting

confidence: 93%

Cisplatin cycles treatment sustains cardiovascular and renal damage involving TLR4 and NLRP3 pathways

González

Gómez-Heras

Franco-Rodríguez

et al. 2023

Pharmacology Res & Perspec

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“…The caspase family is a key element in the process of cell apoptosis. Its activation and overexpression could regulate cell apoptosis through interacting with multiple protein factors [ 25 ]. Caspase-3 is the main effector in the process of apoptosis [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Radiotherapy for the treatment of pulmonary hydatidosis in sheep

Zhang

et al. 2021

Open Life Sciences

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Hydatidosis is an endemic disease causing a severe threat to public health. Drugs and surgery have been utilized for treatment, but their efficiency is not adequate. Therefore, new methods are required for treating such diseases. In this study, we attempt to evaluate the efficiency of radiotherapy for hydatidosis in sheep. The sheep naturally infected with pulmonary hydatid were randomly divided into four groups, including the control group subjected to no irradiation and the other three groups subjected to 30, 45, and 60 Gy irradiation, respectively. Gene expression of caspase-3 and gadd45a and protein expression of BCL-2 and BAX in the lung tissues were evaluated after treatment. Our data showed that the irradiation with a dose of 30, 45, and 60 Gy significantly induced the expression of caspase-3 and gadd45a. Immunohistochemical staining showed that the BCL-2 protein was downregulated after exposure to 45 Gy of irradiation, whereas the BAX expression was downregulated after irradiation at a dose of 45 and 60 Gy, respectively. On this basis, we speculated that 45 Gy might be a safe and effective dose for treating pulmonary hydatidosis in sheep, which induced lower expression of caspase-3 and gadd45a in the cyst and a downregulation of BCL-2 and BAX in the adjacent lung tissues.

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“…DNA damage-induced apoptosis is a cellular defense mechanism to eliminate genetically damaged cells [52,53]. Apoptosis induction is, therefore, an endpoint for screening anticancer action [54,55].…”

Section: Discussionmentioning

confidence: 99%

Effect of Harvest Age on Total Phenolic, Total Anthocyanin Content, Bioactive Antioxidant Capacity and Antiproliferation of Black and White Glutinous Rice Sprouts

Pocasap

Sutthanut

et al. 2020

Applied Sciences

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Black (cv. BGR) and white (cv. RD6) glutinous rice sprouts from fertilizer- and pesticide-free farm in Khon Kaen province, Thailand were investigated for antioxidation and antiproliferative activity. Three different ages of rice sprouts were collected and prepared as the extract. BGR exerted higher antioxidant capacity than RD6 based on total phenolic (TPC) and total anthocyanin contents (TAC), DPPH, and FRAP assays. BGR at 10–15 days contained the highest TPC (29.72 ± 1.42 mg gallic acid equivalent/g extract) and reducing power (2.22 ± 0.014 mmole FeSO4/g extract). BGR at 20–25 days contained the highest TAC (0.86 ± 0.096 equivalence of cyanidin-3-glucoside/g extract) and DPPH radical scavenging activity (IC50 = 231.09 ± 12.99 μg/mL). Antiproliferative activity of the extracts was evaluated in the human T-lymphocyte (Jurkat), hepatocellular carcinoma (HepG2), colorectal carcinoma (HCT116), melanoma (SK-MEL-2) and noncancerous cells (Vero) by neutral red assay. BGR showed the most selective antiproliferation against Jurkat cells, by inducing apoptosis, and caspase 3/7 activity. BGR at 200 μg/mL from all ages significantly decreased ROS using DCFH-DA and increased endogenous glutathione levels in Jurkat cells compared to the control (p < 0.05). The higher antiproliferation of BGR than RD6 was via its antioxidation capacity and attributed to its higher phenolic and anthocyanin contents. BGR sprout is a potential source of biologically active substances good for wellness and health benefits.

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Modulatory effects of perindopril on cisplatin-induced nephrotoxicity in mice: Implication of inflammatory cytokines and caspase-3 mediated apoptosis

Cited by 10 publications

References 31 publications

Cisplatin cycles treatment sustains cardiovascular and renal damage involving TLR4 and NLRP3 pathways

Cisplatin cycles treatment sustains cardiovascular and renal damage involving TLR4 and NLRP3 pathways

Radiotherapy for the treatment of pulmonary hydatidosis in sheep

Effect of Harvest Age on Total Phenolic, Total Anthocyanin Content, Bioactive Antioxidant Capacity and Antiproliferation of Black and White Glutinous Rice Sprouts

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