2010
DOI: 10.1002/mds.22825
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Modulatory effects of 5Hz rTMS over the primary somatosensory cortex in focal dystonia—An fMRI‐TMS study

Abstract: Dystonia is associated with impaired somatosensory ability. The electrophysiological method of repetitive transcranial magnetic stimulation (rTMS) can be used for noninvasive stimulation of the human cortex and can alter cortical excitability and associated behavior. Among others, rTMS can alter/improve somatosensory discrimation abilities, as shown in healthy controls. We applied 5Hz-rTMS over the left primary somatosensory cortex (S1) in 5 patients with right-sided writer's dystonia and 5 controls. We studie… Show more

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Cited by 45 publications
(30 citation statements)
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“…An excitatory high frequency 5 Hz-rTMS was applied over the contralateral primary SSC administered by trains of 50 pulses (1250 pulses) in five writer’s cramp patients. Although it was associated with an increased hemodynamic response of the stimulated S1 cortex, it failed to improve patients’ tactile discrimination in comparison to sham stimulation, in dystonic patients, contrarily to controls subjects (Schneider et al, 2010). In controls, concomitant fMRI showed increased activity of the stimulated S1, bilateral PMC and basal ganglia, whereas, fMRI showed similar cortical effects to controls except for no effects in basal ganglia of dystonia patients.…”
Section: Therapeutic Procedures In Dystoniamentioning
confidence: 99%
See 1 more Smart Citation
“…An excitatory high frequency 5 Hz-rTMS was applied over the contralateral primary SSC administered by trains of 50 pulses (1250 pulses) in five writer’s cramp patients. Although it was associated with an increased hemodynamic response of the stimulated S1 cortex, it failed to improve patients’ tactile discrimination in comparison to sham stimulation, in dystonic patients, contrarily to controls subjects (Schneider et al, 2010). In controls, concomitant fMRI showed increased activity of the stimulated S1, bilateral PMC and basal ganglia, whereas, fMRI showed similar cortical effects to controls except for no effects in basal ganglia of dystonia patients.…”
Section: Therapeutic Procedures In Dystoniamentioning
confidence: 99%
“…Brain imaging studies have shown an increased GMV of the hand representation area of primary somatosensory cortex (SSC) in focal hand dystonia (Garraux et al, 2004), and increased cerebral blood flow using H 2 15 O-PET (Ceballos-Baumann et al, 1995a,b). The impact of tactile discrimination in writer’s cramp patients (Schneider et al, 2010) and blepharospasm (Schmidt et al, 2003) in comparison to controls was illustrated by a greater bilateral ventromedial pallidal activity. Also, dystonic movements can be induced in patients with writer’s cramp by a vibration stimulator (120 Hz; 1-2 mm amplitude) held in the palm during 2-3 min (Kaji et al, 1995).…”
Section: Dystonia: Definition and Anatomical Structures Impairmentmentioning
confidence: 99%
“…In another study, experimenters looked at performance on a purely sensory task following the application of high-frequency rTMS [110]. Those with writer's dystonia showed no change in performance on a frequency discrimination task, while controls showed improvement.…”
Section: Dystoniamentioning
confidence: 99%
“…fMRI analysis highlighted di erences in activation patterns in the basal ganglia between dystonia patients, who showed no increased activation, and controls who exhibited significant activation of this region. It was proposed that the basal ganglia are indirectly activated by the directly stimulated SI, and in those with dystonia, these indirect connections are altered resulting in limited or no activation [110].…”
Section: Dystoniamentioning
confidence: 99%
“…Different protocols of rTMS have demonstrated therapeutic efficacies for various neuropsychiatric disorders such as depression, Parkinson's disease, dystonia, mania, tinnitus, and substance abuse. [2][3][4][5][6][7] Despite controversial findings on the therapeutic outcomes of this technique in different psychiatric disorders, researchers emphasize on developing this technique as an alternative or adjunctive modality for these disorders. Depression, different hallucinations, obsessive-compulsive disorder (OCD), posttraumatic stress disorder (PTSD), migraine tinnitus, substance abuse, and the main disorders have shown good treatment response to rTMS.…”
Section: Introductionmentioning
confidence: 99%