Modulatory effect of macrolide antibiotics on the Th1- and Th2-type cytokine production

Morikawa, Keiko; Zhang, J; Nonaka, Mitsuko; Morikawa, Shigeru

doi:10.1016/s0924-8579(01)00457-5

Cited by 70 publications

(61 citation statements)

References 23 publications

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“…It affects the acute inflammatory cytokine response in vitro and in vivo. It suppresses production of tumor necrosis factor alpha (TNF-␣), interleukin-1␤ (IL-1␤), and IL-1␣ and increases production of IL-10, while contradictory data have been published regarding IL-6 (15)(16)(17)(18). On the other hand, concentrations of TNF-␣, IL-1␤, and IL-6 expressed as protein and mRNA were almost identical with and without fosfomycin in healthy volunteers (19).…”

Section: Immunomodulating Activitymentioning

confidence: 99%

Fosfomycin

et al. 2016

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SUMMARYThe treatment of bacterial infections suffers from two major problems: spread of multidrug-resistant (MDR) or extensively drug-resistant (XDR) pathogens and lack of development of new antibiotics active against such MDR and XDR bacteria. As a result, physicians have turned to older antibiotics, such as polymyxins, tetracyclines, and aminoglycosides. Lately, due to development of resistance to these agents, fosfomycin has gained attention, as it has remained active against both Gram-positive and Gram-negative MDR and XDR bacteria. New data of higher quality have become available, and several issues were clarified further. In this review, we summarize the available fosfomycin data regarding pharmacokinetic and pharmacodynamic properties, thein vitroactivity against susceptible and antibiotic-resistant bacteria, mechanisms of resistance and development of resistance during treatment, synergy and antagonism with other antibiotics, clinical effectiveness, and adverse events. Issues that need to be studied further are also discussed.

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Section: Immunomodulating Activitymentioning

confidence: 99%

Fosfomycin

et al. 2016

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“…In these experiments, erythromycin did not decrease Th2-related cytokines or mRNAs. Clarithromycin and other macrolides were reported to inhibit Th1 cytokines, such as IL-2 and TNF-␣, more markedly than Th2-type cytokines produced by mitogen-stimulated human T lymphocytes in vitro (197).…”

Section: Effects On Inflammationmentioning

confidence: 99%

Mechanisms of Action and Clinical Application of Macrolides as Immunomodulatory Medications

2010

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SUMMARY Macrolides have diverse biological activities and an ability to modulate inflammation and immunity in eukaryotes without affecting homeostatic immunity. These properties have led to their long-term use in treating neutrophil-dominated inflammation in diffuse panbronchiolitis, bronchiectasis, rhinosinusitis, and cystic fibrosis. These immunomodulatory activities appear to be polymodal, but evidence suggests that many of these effects are due to inhibition of extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation and nuclear factor kappa B (NF-κB) activation. Macrolides accumulate within cells, suggesting that they may associate with receptors or carriers responsible for the regulation of cell cycle and immunity. A concern is that long-term use of macrolides increases the emergence of antimicrobial resistance. Nonantimicrobial macrolides are now in development as potential immunomodulatory therapies.

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“…Renewed attention has been paid to FOF because of its effects on the acute inflammatory cytokine response in vitro as well as in vivo in mice (8,15,18,19). Since these effects might be beneficial also in septic patients, the present study was carried out to quantify the immunomodulatory properties of FOF in vivo during experimental endotoxemia in humans induced by the administration of bacterial LPS (10,16).…”

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confidence: 99%

Immunomodulatory Effects of Fosfomycin in Experimental Human Endotoxemia

Sauermann

Marsik²,

Steiner

et al. 2007

Antimicrob Agents Chemother

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To evaluate the effect of fosfomycin on proinflammatory cytokines, a bolus of 2 ng of bacterial lipopolysaccharide/kg of body weight was injected intravenously into healthy volunteers. After 2 h, subjects received 8 g of fosfomycin or placebo in a randomized crossover study design. The resulting concentrations of tumor necrosis factor alpha, interleukin-1␤ (IL-1␤), and IL-6 expressed as protein and mRNA levels were almost identical with and without fosfomycin.

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Modulatory effect of macrolide antibiotics on the Th1- and Th2-type cytokine production

Cited by 70 publications

References 23 publications

Fosfomycin

Fosfomycin

Mechanisms of Action and Clinical Application of Macrolides as Immunomodulatory Medications

Immunomodulatory Effects of Fosfomycin in Experimental Human Endotoxemia

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