Modulatory Effect of Ethanolic Leaf Extract of Annona muricata Pre-treatment on Liver Damage Induced by Dimethylnitrosamine (DMN) in Rats

Abstract

Aim: This study aim to evaluate the modulatory effect of ethanolic leaf extract of Annona muricata against dimethylnitrosamine (DMN)-induced hepatic toxicity in rats. Methodology: Twenty-four (24) male albino rats divided into four (4) groups of six (6) rats each were used for the study. Group 1 served as control and was untreated, group 2 and 3 were pretreated with 400 mg/kg Annona muricata for one week while group 3 and 4 each received a single oral dose of 20 mg/kg DMN after one week. The rats were sacrificed 48 hrs after DMN administration.

Ameliorative Effect of Graviola (Annona muricata) on Mono Sodium Glutamate-Induced Hepatic Injury in Rats: Antioxidant, Apoptotic, Anti-inflammatory, Lipogenesis Markers, and Histopathological Studies

“…An oral administration of Graviola normalized the body weight, and these findings are in agreement with [61][62][63]. The decrease in triglyceride and overall cholesterol is attributed to this, since Graviola has a hypolipidemic effect and hypolipidemic agents such as tannins, which reduce the cholesterol absorption and, consequently, reduce the body weight gain [64,65]. The lipid profile, including total cholesterol (TC), triglyceride (TG), and LDL-C, increased significantly in the serum of rats administered MSG.…”

“…The prophylactic and protective roles of orally administered Graviola in normalized parameters of the lipid profile, as shown in Table 3, could be attributed to the involvement of hypolipidemic agents in the GE [62,63]. The hypolipidemic and antioxidant effects of Graviola due to the presence of agents such as tannins and other polyphenolic compounds cause decreasing cholesterol absorption by deactivating coenzyme-A (HMG-CoA) reductase hydroxymethylglutaryl [65]. Our findings showed that MSG can significantly increase the liver enzymes ALT, AST, ALP, and GGT due to the cytotoxic effect of MSG, which resulted in damage to liver cells and canaculae and the release of these enzymes in the circulation [68].…”

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“…The prophylactic and curative effects of GAE in enhanced the serum lipid profile parameters could be attributed to the involvement of hypolipidemic effect in the GAE [59,80]. The different biological effects (hypolipidemic, antioxidant and scavenging activities) of GAE probably due to the presence of bioactive compounds such as alkaloids, acetogenins and polyphenolic compounds cause decreasing cholesterol absorption by deactivating the coenzyme-A (HMG-CoA) reductase hydroxymethylglutaryl [81]. Also, McAnlis, et al [82] suggested that quercetin found in GAE, having a high affinity for protein, was bound to albumin and never incorporated into the LDL particle.…”