Modulatory effect of agents active in the presynaptic dopaminergic system on the striatal dopamine transporter

Changes of Dopamine Transporter Availability in Depressed Patients with and without Anhedonia: A ¹²³I-N-ω-Fluoropropyl-Carbomethoxy-3β- (4-Iodophenyl)tropane SPECT Study

“…The fact that DAT decreases in density after chronic DA depletion [47,48] supports this hypothesis. Reduced DAT availability may also represent a striatal-mediated dysregulation of cortical and limbic structures, reflecting affective and psychomotor changes that occur in depression [20,49] .…”

Effects of Early Life Stress on [11C]DASB Positron Emission Tomography Imaging of Serotonin Transporters in Adolescent Peer- and Mother-Reared Rhesus Monkeys

“…Alternatively, altered regulation of SERT protein expression may explain the BP decreases found in the present study. In the case of dopamine transporter (DAT), extracellular dopamine levels are known to regulate the transporter density (Gordon et al, 1996;Han et al, 1999). However, evidence suggests that extracellular 5-HT levels typically show no influence on regional SERT density (Graham et al, 1987;Dewar et al, 1992;Benmansour et al, 1999).…”

Pyrethroid pesticide-induced alterations in dopamine transporter function

“…In this study, we found significant increases in DAT-binding sites as measured with 3 H-WIN 35,428 that mirrored the increase in DAT-mediated dopamine uptake. While no specific mechanism has been identified for the increase of DAT by these compounds, chemicals known to cause dopamine release, like amantidine and the organo-chlorine pesticide heptachlor, can increase DAT expression (Gordon et al, 1996;Miller et al, 1999aMiller et al, , 1999bPage et al, 2000;Kirby et al, 2002). If this were to be sustained over time, one would expect that the elevated extracellular dopamine would increase the expression of the dopamine transporter in an attempt to clear and recycle dopamine.…”