Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in<i>Drosophila melanogaster</i>

Majeed, Zana R.; Abdeljaber, Esraa; Soveland, Robin; Cornwell, Kristin; Bankemper, Aubrey; Koch, Felicitas; Cooper, Robin L.

doi:10.1155/2016/7291438

Cited by 59 publications

(73 citation statements)

References 75 publications

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“…5-HT is a major neuromodulator of motor behaviors ( Figure 1A) in many species belonging to different invertebrate phyla. This includes flatworms [58], cnidarians [59], nematodes [60], annelids [61,62], arthropods (insects and crustaceans, [63][64][65]), and mollusks [66][67][68][69]. Part of our knowledge comes from studies investigating the ecological/toxicological consequences of SSRIs used as antidepressants, released in sanitary water, and finally spread in rivers [63,65,[70][71][72].…”

Section: Motor Activity and Locomotionmentioning

confidence: 99%

Serotonin in Animal Cognition and Behavior

Bacqué-Cazenave

Bharatiya

Barrière

et al. 2020

IJMS

181

111

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Serotonin (5-hydroxytryptamine, 5-HT) is acknowledged as a major neuromodulator of nervous systems in both invertebrates and vertebrates. It has been proposed for several decades that it impacts animal cognition and behavior. In spite of a completely distinct organization of the 5-HT systems across the animal kingdom, several lines of evidence suggest that the influences of 5-HT on behavior and cognition are evolutionary conserved. In this review, we have selected some behaviors classically evoked when addressing the roles of 5-HT on nervous system functions.In particular, we focus on the motor activity, arousal, sleep and circadian rhythm, feeding, social interactions and aggressiveness, anxiety, mood, learning and memory, or impulsive/compulsive dimension and behavioral flexibility. The roles of 5-HT, illustrated in both invertebrates and vertebrates, show that it is more able to potentiate or mitigate the neuronal responses necessary for the fine-tuning of most behaviors, rather than to trigger or halt a specific behavior. 5-HT is, therefore, the prototypical neuromodulator fundamentally involved in the adaptation of all organisms across the animal kingdom.The organization of the 5-HT systems is completely different between species ranging from a limited number of cells in Aplysia or Drosophila (100 5-HT immunoreactive cells) to several thousand neurons in vertebrates. The variety and the heterogeneity of 5-HT neurons have been highlighted in vertebrates [7] as well as in invertebrates [8]. In general, the 5-HT systems in animals comprise 5-HT neurons, which share a particular shape made of thousands of varicosities, leading to the concept of volume transmission [9], and several 5-HT receptors (5-HTRs). In vertebrates, 5-HT neurons are localized in the midbrain raphe nuclei described as the B1-B9 cell groups [1,10]. The raphe pallidus, obscurus, and pontis form a caudal cluster (B1-B5), whereas the dorsal raphe and median raphe form a rostral cluster in the pons (B6-B9) [11]. The caudal raphe group projects to the spinal cord and the rostral group to the forebrain via an extensive and diffuse innervation. The dorsal raphe nucleus contains the highest number of 5-HT neurons and its anatomical sub-regions display some degrees of specific innervation of the forebrain [12][13][14]. The median and dorsal raphe nuclei receive excitatory and inhibitory inputs from most brain areas [15]. In crustaceans or insects, 5-HT neurons are widely present in each of the ventral cord ganglia, display large local ramifications that act in multiple neuropil areas, and some axonal branches form three pairs of rostrocaudal fibers [16][17][18][19]. Presumably, two of those fibers would project anteriorly and one posteriorly to the entire nervous system [20]. 5-HT neurons are often localized close to sensory integration input area in the brain of arthropods and some 5-HT cells in the abdominal ganglia of crayfish nerve cord are sensitive to the mechanical stimulation of abdominal segmental fringe hairs [21]. In cnidarians, 5-HT cells ...

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Section: Motor Activity and Locomotionmentioning

confidence: 99%

Serotonin in Animal Cognition and Behavior

Bacqué-Cazenave

Bharatiya

Barrière

et al. 2020

IJMS

181

111

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“…We focused on receptors for the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) because of serotonin's role as a neuromodulator [31]. The effects of serotonin depend on receptor-specific binding, and in Drosophila and other insects 5-HT receptors have been associated with variation in locomotion, feeding behavior, learning and memory, and aggression [32,33].…”

Section: Divergence In 5-hydroxytryptamine Receptor 2a (5-ht2a)mentioning

confidence: 99%

Whole Genome Sequencing and Assembly of the Asian Honey Bee Apis dorsata

Oppenheim

Cao

Rueppel³

et al. 2019

Preprint

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The Asian honey bee (Apis dorsata) is distinct from its more widely distributed cousin A. mellifera by a few key characteristics. Most prominently, A. dorsata, nest in the open by forming a colony clustered around the honeycomb, while A. mellifera nest in concealed cavities.Additionally, the worker and reproductive castes are all of the same size in A. dorsata. In order to investigate these differences, we performed whole genome sequencing of A. dorsata using a hybrid Oxford Nanopore and Illumina approach. The 223MB genome has an N50 of 35kb with the largest scaffold of 302kb. We have found that there are many genes in the dorsata genome that are distinct from other hymenoptera and also large amounts of transposable elements, and we suggest some candidate genes for A. dorsata's exceptional level of defensive aggression.

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“…Serotonin (5-hydroxytryptamine; 5-HT) signalling influences numerous Drosophila behaviours, including sleep (Yuan, Joiner, and Sehgal 2006;Nichols 2007) , courtship (Pooryasin and Fiala 2015) , place learning ) and aversive olfactory conditioning. Flies express five serotonin receptors: 5HT1A, 5HT1B, 5HT2A, 5HT2B and 5HT7 (Johnson, Becnel, and Nichols 2011;Majeed et al 2016;Gasque et al 2013) . Loss-of-function mutants for three of these receptors ( 5HT1B , 5HT2A , and 5HT7 ) have been analyzed by T-maze olfactory conditioning, but no replication studies have been reported.…”

Section: Stm Relies On Serotonin Receptorsmentioning

confidence: 99%

A systematic review ofDrosophilashort-term-memory genetics: meta-analysis reveals robust reproducibility

Tumkaya

Ott

Claridge‐Chang

2018

Preprint

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Geneticists have long used olfactory conditioning techniques in Drosophila to identify the neurons and genes that mediate learning. While this method has characterized an abundance of memory-related genes, little is known about how these genes induce short-term memory (STM) via signaling pathways; characterizing these networks will be essential to developing mechanistic models of memory formation. Here, we investigated why elucidating the STM pathways has been relatively slow. One possibility is that the STM evidence base is weak due to publication of poorly reproducible results, as has been observed in other fields. We examined this hypothesis by performing a systematic review and subsequent meta-analysis of the STM genetics field. Using several metrics to quantify the variation between discovery articles and follow-up studies, we found that seven genes were highly replicated, showed no publication bias, and had generally high reproducibility. However, the remaining ~80% memory genes have not been replicated since their initial discovery. Although we observed only a few studies that investigated gene interactions, the reviewed genes could together account for >1000% memory. This large summed effect size indicates either that some of the gene findings are not reproducible, that many memory genes participate in shared pathways, or that current protocols lack the specificity needed to identify core plasticity memory genes. Mechanistic theories of memory and cognition will require the convergence of evidence from system, circuit, cellular, molecular, and genetic experiments. As this study demonstrates, systematic data synthesis is an essential tool for this integrated brain science.

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Modulatory Action by the Serotonergic System: Behavior and Neurophysiology inDrosophila melanogaster

Cited by 59 publications

References 75 publications

Serotonin in Animal Cognition and Behavior

Serotonin in Animal Cognition and Behavior

Whole Genome Sequencing and Assembly of the Asian Honey Bee Apis dorsata

A systematic review ofDrosophilashort-term-memory genetics: meta-analysis reveals robust reproducibility

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