Modulations of the Bcl-2/Bax Family Were Involved in the Chemopreventive Effects of Licorice Root (<i>Glycyrrhiza uralensis Fisch</i>) in MCF-7 Human Breast Cancer Cell

Jo, Eunhye; Hee-Do, Hong; Ahn, Nam-Chik; Jung, Ji‐Won; Yang, Se‐Ran; Park, Joon-Suk; Kim, Sung Hoon; Lee, Yong-Soon; Kang, Kyung‐Sun

doi:10.1021/jf035012t

Cited by 64 publications

(40 citation statements)

References 18 publications

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“…Licorice root contains alkaloids, polysaccharides, and flavonoids (32). Previous studies have reported licorice-induced cancer-specific cell death in various cancer cell types, including oral (7,11), prostate (13), colon (33) and breast cancer (34,35), through the inhibition of proliferation (11) and metastasis (18), cell-cycle arrest (13,14), and apoptotic cell death (14). Licochalcone-A, a chalconoid and a type of natural phenol, has been isolated from the root of the licorice plant and has exhibited various pharmacological effects, including antimalarial, anticancer, antibacterial and antiviral properties (7).…”

Section: Discussionmentioning

confidence: 99%

Licochalcone-E induces caspase-dependent death of human pharyngeal squamous carcinoma cells through the extrinsic and intrinsic apoptotic signaling pathways

Cho

Kang

et al. 2017

Oncology Letters

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Abstract. The aim of the present study was to investigate licochalcone-E (Lico-E)-induced apoptosis and the associated apoptotic signaling pathway in FaDu cells, a human pharyngeal squamous carcinoma cell line. Treatment with Lico-E exhibited significant cytotoxicity on FaDu cells in a concentration-dependent manner. The IC 50 value of Lico-E in FaDu cells was ~50 µM. Treatment with Lico-E increased the number of dead FaDu cells. Furthermore, chromatin condensation, which is associated with apoptotic cell death, was observed in FaDu cells treated with Lico-E for 24 h. By contrast, Lico-E did not produce cytotoxicity or increase the number of dead cells when applied to human normal oral keratinocytes (hNOKs). Furthermore, chromatin condensation was not observed in hNOKs treated with Lico-E. Treatment with Lico-E increased the expression of Fas ligand and the cleaved form of caspase-8 in FaDu cells. Furthermore, treatment with Lico-E increased the expression of pro-apoptotic factors, including apoptosis regulator BAX, Bcl-2-associated agonist of cell death, apoptotic protease-activating factor 1, caspase-9 and tumor suppressor p53, while decreasing the expression of anti-apoptotic factors, including apoptosis regulator Bcl-2 and Bcl-2-like protein 1 in FaDu cells. The expression of cleaved caspases-3 and poly (ADP-ribose) polymerase was significantly upregulated following treatment with Lico-E in FaDu cells, while Lico-E-induced apoptotic FaDu cell death was partially suppressed by treatment with Z-VAD-FMK, a pan caspase inhibitor. Therefore, Lico-E-induced oral cancer (OC) cell-specific apoptosis is mediated by the death receptor-dependent extrinsic and mitochondrial-dependent intrinsic apoptotic signaling pathways. In conclusion, these data suggested that Lico-E exhibits potential chemopreventive effects and warrants further developed as a chemotherapeutic agent against OC.

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Section: Discussionmentioning

confidence: 99%

Licochalcone-E induces caspase-dependent death of human pharyngeal squamous carcinoma cells through the extrinsic and intrinsic apoptotic signaling pathways

Cho

Kang

et al. 2017

Oncology Letters

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“…Preparations of plants, based on ancient recipes from Chinese or Japanese medical tradition, are mainly popular in Asia and North America [85]. Many mixtures are known to have an anticancerous effect in vitro [86][87][88], yet, no clinical trials have been performed to study efficacy and safety in breast cancer patients.…”

Section: Herbal Medical Productsmentioning

confidence: 99%

Complementary and alternative therapeutic approaches in patients with early breast cancer: a systematic review

Gerber

Scholz

Reimer

et al. 2005

Breast Cancer Res Treat

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Complementary and alternative medicine (CAM) is becoming increasingly popular, particularly among patients with breast cancer. We have done a systematic review of studies published between 1995 and February 2005, identified through a comprehensive search. CAM encompasses a wide range of treatment modalities, including dietary and vitamin supplements, mind-body approaches, acupuncture, and herbal medicines. The objectives of CAM treatments are diverse: reduction of therapy-associated toxicity, improvement of cancer-related symptoms, fostering of the immune system and even direct anticancer effects. Clinical trials have generated few or no data on the efficacy of CAM, whether regarding disease recurrence, survival, overall quality of life or safety. Some CAM methods may even have adverse effects or reduce the efficacy of conventional treatment. The primary justification for CAM is based on empirical evidence, case studies, and hypothetical physiological effects. We conclude that available data on CAM modalities in the treatment of early-stage breast cancer does not support their application.

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“…Presently, there is a considerable scientific discovery for the invention of anticancer agents from natural products [2]. In light of the continuing need for effective anticancer agents and edible plants are increasingly being considered as sources of anticancer drugs [3][4]. In extent, there is a large amount of scientific evidence showing that the fruits and vegetables lower the risk of cancer [5].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of in Vitro Anticancer and Antioxidant Activities From Leaf Extracts of Medicinal Plant Clidemia Hirta

Narasimham

Bindu

Cheriyamundath

et al. 2017

Int J Pharm Pharm Sci

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Objective: To evaluate the anticancer and antioxidant activity of medicinal plant Clidemia hirta extracted in different solvents. Methods:Crude extracts were prepared from the leaves of Clidemia hirta using ethanol, petroleum ether and chloroform solvents. Anticancer activities and antioxidant properties were assayed using standard yellow dye 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) and 1, 1-diphenyl-2-picryl hydrazyl (DPPH) free radical scavenging assay respectively. Results:We found that the ethanol extract had higher inhibition activities against Dalton's lymphoma ascites (DLA) cancer cell line, 50% DLA cell line inhibition at 68µg/ml, while 50% inhibition by petroleum ether and chloroform extracts were at 160µg/ml and 172µg/ml, respectively. The antioxidant activity requires5µg/ml of ethanol extract to trap 50% of DPPH (IC50), whereas the positive control ascorbic acid trapped 50% of DPPH (IC50) at 3.5µg/ml. Conclusion:The prepared leaf extracts with different solvents of Clidemia hirta showed the antiproliferative and antioxidant activity in dosedependent manner. Further works is required to identify the biologically active chemical constituents, responsible for cancer cell growth inhibition from this plant.

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Modulations of the Bcl-2/Bax Family Were Involved in the Chemopreventive Effects of Licorice Root (Glycyrrhiza uralensis Fisch) in MCF-7 Human Breast Cancer Cell

Cited by 64 publications

References 18 publications

Licochalcone-E induces caspase-dependent death of human pharyngeal squamous carcinoma cells through the extrinsic and intrinsic apoptotic signaling pathways

Licochalcone-E induces caspase-dependent death of human pharyngeal squamous carcinoma cells through the extrinsic and intrinsic apoptotic signaling pathways

Complementary and alternative therapeutic approaches in patients with early breast cancer: a systematic review

Evaluation of in Vitro Anticancer and Antioxidant Activities From Leaf Extracts of Medicinal Plant Clidemia Hirta

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