Modulations of Immune Functions and Oxidative Status Induced by Noise Stress

Abstract

Modulations of Immune Functions andOxidative Status Induced by Noise Stress: KuiCheng ZHENG, et al. Department of Environmental and Preventive Medicine, Faculty of Medicine, University of the Ryukyus-Noise has long been realized as an environmental stress causing physiological, psychological and behavioral changes in humans. The aim of the present study was to determine the effect of acute or chronic noise stress on both cellular and humoral immune responses and oxidative status. BALB/c mice were exposed to 90 dB (A) white noise 5 h per day for either 3 d or 4 wk. Hormone levels, splenic lymphocyte proliferation, lymphocyte subsets in spleen and thymus, serum antibody and oxidative status were determined. A 3-d exposure to noise stress resulted in increased hormone levels, splenic lymphoproliferation and serum IgM. On the other hand, a 4-wk exposure to noise stress caused a reduction of splenic lymphoproliferation, splenic CD4 + cells and serum IgG, but hormone levels and urinary 8-hydroxy-2'deoxyguanosine (8-OHdG) were increased. These results imply that acute exposure to noise stress may enhance immune responses, whereas chronic exposure to noise stress may suppress both cellular and humoral immune functions. The effect of noise stress on immune functions may be related to neuroendocrine modulation and oxidative imbalance as well. (J Occup Health 2007; 49: 32-38)

Heat-shock response protects peripheral blood mononuclear cells (PBMCs) from hydrogen peroxide-induced mitochondrial disturbance

“…PBMCs are more sensitive than neutrophils in intense exercise-induced oxidative damage (Sureda et al 2005) and are useful tools as markers reflecting the systemic symptoms of oxidative stress under physical and mental stimulation (Aslan et al 2006;Fedeli et al 2007;Zalata et al 2007;Zheng and Ariizumi 2007). PBMCs are utilized in the present study; they are sensitive to hydrogen-peroxide-induced oxidative stress and are also highly susceptible in their response to heat-shock-responseassociated protective effects.…”

Effect of Chronic Noise Stress on Serum Glucose and Lipids and Morphology of Langerhans Islets in Neonatal Rats

“…Animal studies have also shown that different kinds of stressors may induce or inhibit type 1 diabetes in different experimental models of the disease [7]. Noise pollution is one of the harmful environmental factors for humans when it is higher than normal, could adversely affects to health [8,9]. Noise as an environmental stress causes physiological and psychological changes in humans [10].…”

Chronic Individual Housing-Induced Stress Decreased Expression of Catecholamine Biosynthetic Enzyme Genes and Proteins in Spleen of Adult Rats

“…Several authors observed a significant increase of TH mRNA and PNMT mRNA levels in the spleen of animals exposed to acute and short-term stress [17,18] . Zheng and Atiizumi [29] demonstrated that acute exposure to noise stress may enhance immune response, whereas chronic exposure to the same stress may suppress both cellular and humoral immune functions. They hypothesized that the effect of acute and chronic noise stress on immune functions might be related to a neuroendocrine modulation.…”