Abstract:Background] MeHg known as a causative factor of Minamata disease induces neuronal cell death and damage the central nervous system, but the mechanism is poorly understood. Previously, we reported that MeHg induces S-mercuration at cysteine 383 or 386 in protein disulfide isomerase (PDI), and this modification induces the loss of enzymatic activity. Because PDI is a key enzyme for the maturation of nascent protein harboring a disulfide bond, the disruption in PDI function by MeHg results in endoplasmic reticulu… Show more
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