Modulation of tissue factor and tissue factor pathway inhibitor-1 by neutrophil proteases

Steppich, Birgit; Seitz, Isabell; Busch, Gabi; Stein, Andreas; Ott, Ilka

doi:10.1160/th08-05-0293

Cited by 35 publications

(22 citation statements)

References 27 publications

(32 reference statements)

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“…Beyond the well known inflammatory and antimicrobial actions, neutrophils have been increasingly recognized as important contributors to several physiologic processes. In particular activated neutrophils exhibit significant pro-coagulant properties (21–23). First, neutrophils shift the coagulation balance in favor of thrombus formation through significant expression and release of tissue factor (TF) (24).…”

Section: Discussionmentioning

confidence: 99%

Leukocyte Count and Intracerebral Hemorrhage Expansion

Morotti

Phuah

Anderson

et al. 2016

Stroke

108

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Background and purpose Acute leukocytosis is a well-established response to intracerebral hemorrhage (ICH). Leukocytes, because of their interaction with platelets and coagulation factors, may in turn play a role in hemostasis. We investigated whether admission leukocytosis was associated with reduced bleeding following acute ICH. Methods Consecutive patients with primary ICH were prospectively collected from 1994 to 2015 and retrospectively analyzed. We included subjects with a follow-up CT scan available and automated complete white blood cell (WBC) count performed within 48 h from onset. Baseline and follow-up hematoma volumes were calculated with semi-automated software and hematoma expansion was defined as volume increase > 30% or 6 mL. The association between WBC count and ICH expansion was investigated with multivariate logistic regression. Results 1302 subjects met eligibility criteria (median age 75 years, 55.8 % males), of whom 207 (15.9 %) experienced hematoma expansion. Higher leukocyte count on admission was associated with reduced risk of hematoma expansion (Odds Ratio for 1000 cells increase [OR] 0.91, 95 % Confidence Interval [CI] 0.86–0.96, p=0.001). The risk of hematoma expansion was inversely associated with neutrophil count (OR 0.90, 95 % CI 0.85–0.96, p=0.001) and directly associated with monocyte count (OR 2.71, 95 % CI 1.08–6.83, p=0.034). There was no association between lymphocyte count and ICH expansion (OR 0.96, 95 % CI 0.79–1.17, p=0.718). Conclusions Higher admission WBC count is associated with lower risk of hematoma expansion. This highlights a potential role of the inflammatory response in modulating the coagulation cascade following acute ICH.

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Section: Discussionmentioning

confidence: 99%

Leukocyte Count and Intracerebral Hemorrhage Expansion

Morotti

Phuah

Anderson

et al. 2016

Stroke

108

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“…NE also participates in the release of proinflammatory cytokines and is associated with apoptosis of epithelial cells. NE contributes to the proteolytic cleavage of TFPI as well, while it enhances the activation of fX, thus regulating the procoagulant process [94,95] . In addition, MPO is leading to the production of reactive oxygen species, contributing to epithelial cells apoptosis [96] .…”

Section: Neutrophil Extracellular Trapsmentioning

confidence: 99%

Immunothrombosis in Acute Respiratory Distress Syndrome: Cross Talks between Inflammation and Coagulation

Frantzeskaki¹,

Armaganidis²,

Orfanos³

2016

Respiration

220

251

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Acute respiratory distress syndrome (ARDS) is defined as a syndrome of acute onset, with bilateral opacities on chest imaging and respiratory failure not caused by cardiac failure, leading to mild, moderate, or severe oxygenation impairment. The syndrome is most commonly a manifestation of sepsis-induced organ dysfunction, characterized by disruption of endothelial barrier integrity and diffuse lung damage. Imbalance between coagulation and inflammation is a predominant characteristic of ARDS, leading to extreme inflammatory response and diffuse fibrin deposition in vascular capillary bed and alveoli. Activated platelets, neutrophils, endothelial cells, neutrophil extracellular traps, microparticles, and coagulation proteases, participate in the complex process of immunothrombosis, which is a key event in ARDS pathophysiology. The present review is focused on the elucidation of immunothrombosis in ARDS and the potential therapeutic implications.

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“…Other molecules secreted by activated leucocytes, including proteinase 3, elastase and cathepsin G, influence the generation of thrombin further [93][94][95]. The role of ANCA on these events deserves careful investigation.…”

Section: The Cross-talk Between Activated Platelets and Circulating Lmentioning

confidence: 99%

Translational Mini-Review Series on Immunology of Vascular Disease: Mechanisms of vascular inflammation and remodelling in systemic vasculitis

Maugeri

Rovere‐Querini

Baldini

et al. 2009

Clinical and Experimental Immunology

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SummaryVessel walls are the primary inflammatory sites in systemic vasculitides. In most cases the initiating event is unknown, and a self-sustaining circuit attracts and activates inflammatory leucocytes in the wall of vessels of various size and anatomical characteristics. Recent studies have revealed homeostatic roles of vascular inflammation and have identified the action of humoral innate immunity, in particular injury-associated signals and acute phase proteins, on the activation of circulating leucocytes, platelets and endothelial cells. These advances have provided clues to the molecular mechanisms underlying the vicious circle that maintains and amplifies vessel and tissue injury.

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Modulation of tissue factor and tissue factor pathway inhibitor-1 by neutrophil proteases

Cited by 35 publications

References 27 publications

Leukocyte Count and Intracerebral Hemorrhage Expansion

Leukocyte Count and Intracerebral Hemorrhage Expansion

Immunothrombosis in Acute Respiratory Distress Syndrome: Cross Talks between Inflammation and Coagulation

Translational Mini-Review Series on Immunology of Vascular Disease: Mechanisms of vascular inflammation and remodelling in systemic vasculitis

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