“…Several research groups have developed new approaches to quantify the fundamental disintegration mechanisms using high-speed imaging (Berardi et al, 2018;Basaleh et al, 2020), terahertz pulsed imaging (Markl et al, 2018Al-Sharabi et al, 2020), magnetic resonance imaging (Quodbach et al, 2014a,b;Dvořák et al, 2020;Catellani et al, 1989), and water uptake and (swelling) force measurements (Caramella et al, 1986;Peppas and Colombo, 1989;Tomas et al, 2018). The liquid uptake and wettability of powder and pharmaceutical compacts were also investigated using the sessile drop method, where several groups observed a correlation between the wettability characteristics and the disintegration/dissolution performance of tablets for a range of different formulations (Yang et al, 2016(Yang et al, , 2018Liu et al, 2018;Yang et al, 2019).…”