Modulation of the sensorimotor system by sustained manual pressure stimulation

Hok, Pavel; Opavský, J; Kutín, Miroslav; Tüdös, Zbyněk; Kaňovský, Petr; Hluštı́k, Petr

doi:10.1016/j.neuroscience.2017.02.005

Cited by 23 publications

(39 citation statements)

References 52 publications

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“…Moreover, the internal pallidum serves as a target for effective modulation of CD and other forms of primary dystonias using deep brain stimulation, with an imprecisely characterized mode of action. Whereas higher field MR scanners have certainly provided better spatial and temporal resolution, our spatial resolution of 3.5 × 3.5 × 5 mm appears sufficient to reliably detect basal ganglia activation in normal subjects and neurological patients (Obermann et al 2008 ; Hok et al 2017 ; Marchal-Crespo et al 2017 ).…”

Section: Discussionmentioning

confidence: 99%

“…We acknowledge that the controls were scanned only once, whereas a balanced design would be more powerful to rule out effects of repeated motor testing. Nevertheless, single repetition of a motor task typically leads to a decrease, rather than increase, in sensorimotor activation (Hok et al 2017 + další mimoOl citace). MRI-compatible electromyographic recording from the cervical musculature would permit modeling the influences of possible changes in dystonic activity after BoNT treatment.…”

Section: Discussionmentioning

confidence: 99%

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Changes in sensorimotor network activation after botulinum toxin type A injections in patients with cervical dystonia: a functional MRI study

et al. 2018

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Botulinum toxin type A (BoNT) is considered an effective therapeutic option in cervical dystonia (CD). The pathophysiology of CD and other focal dystonias has not yet been fully explained. Results from neurophysiological and imaging studies suggest a significant involvement of the basal ganglia and thalamus, and functional abnormalities in premotor and primary sensorimotor cortical areas are considered a crucial factor in the development of focal dystonias. Twelve BoNT-naïve patients with CD were examined with functional MRI during a skilled hand motor task; the examination was repeated 4 weeks after the first BoNT injection to the dystonic neck muscles. Twelve age- and gender-matched healthy controls were examined using the same functional MRI paradigm without BoNT injection. In BoNT-naïve patients with CD, BoNT treatment was associated with a significant increase of activation in finger movement-induced fMRI activation of several brain areas, especially in the bilateral primary and secondary somatosensory cortex, bilateral superior and inferior parietal lobule, bilateral SMA and premotor cortex, predominantly contralateral primary motor cortex, bilateral anterior cingulate cortex, ipsilateral thalamus, insula, putamen, and in the central part of cerebellum, close to the vermis. The results of the study support observations that the BoNT effect may have a correlate in the central nervous system level, and this effect may not be limited to cortical and subcortical representations of the treated muscles. The results show that abnormalities in sensorimotor activation extend beyond circuits controlling the affected body parts in CD even the first BoNT injection is associated with changes in sensorimotor activation. The differences in activation between patients with CD after treatment and healthy controls at baseline were no longer present.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Changes in sensorimotor network activation after botulinum toxin type A injections in patients with cervical dystonia: a functional MRI study

et al. 2018

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“…Moreover, the results of this intervention show a relationship with the only similar study found to date. [ 23 ] This survey found an increase of the cerebral activity in the contralateral pontomedular reticular formation, in the posterior bilateral hemisphere and vermis. Contrary to this study, we used the pectoral area to perform the stimulation, obtaining a different activation in a greater number and specificity of cortical areas (Brodmann 46, 20, 21, 22, hippocampal gyrus, and inferior frontal gyrus), and a greater specificity in the results on active subcortical structures (putamen, globus pallidus, subthalamic nucleus of luys, C, mammillary bodies, and red nucleus).…”

Section: Discussionmentioning

confidence: 99%

“…According to Hok et al, [ 23 ] the brainstem modulation role after peripheral pressure stimulation and the after-effects of reflex locomotion physiotherapy involve a modulation of the pontomedullary reticular formation. This may be a strong hypothesis in order to justify the Vojta therapy mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Mapping the human brain during a specific Vojta's tactile input

Sanz-Esteban

Calvo‐Lobo²,

Ríos-Lago

et al. 2018

Medicine

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A century of research in human brain parcellation has demonstrated that different brain areas are associated with functional tasks. New neuroscientist perspectives to achieve the parcellation of the human brain have been developed to know the brain areas activation and its relationship with different stimuli. This descriptive study aimed to compare brain regions activation by specific tactile input (STI) stimuli according to the Vojta protocol (STI-group) to a non-STI stimulation (non-STI-group). An exploratory functional magnetic resonance imaging (fMRI) study was performed. The 2 groups of participants were passively stimulated by an expert physical therapist using the same paradigm structure, although differing in the place of stimulation. The stimulation was presented to participants using a block design in all cases. A sample of 16 healthy participants, 5 men and 11 women, with mean age 31.31 ± 8.13 years was recruited. Indeed, 12 participants were allocated in the STI-group and 4 participants in the non-STI-group. fMRI was used to map the human brain in vivo while these tactile stimuli were being applied. Data were analyzed using a general linear model in SPM12 implemented in MATLAB. Differences between groups showed a greater activation in the right cortical areas (temporal and frontal lobes), subcortical regions (thalamus, brainstem, and basal nuclei), and in the cerebellum (anterior lobe). STI-group had specific difference brain activation areas, such as the ipsilateral putamen. Future studies should study clinical implications in neurorehabilitation patients.

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“…Whereas the influence on human motor activity has been repeatedly studied 2-5 , we have not found any reports of the effect of Vojta Therapy on autonomic activity and autonomic control in the published literature. Our previous study using functional MRI of the brain demonstrated specific modulation of hand motor control in the pontomedullary reticular formation (PMRF) following the stimulation according to Vojta 5 . Besides motor control, the PMRF is also implicated in various aspects of autonomic control 6 .…”

Section: Introductionmentioning

confidence: 99%