Modulation of the satiety effect of cholecystokinin by estradiol

Butera, Peter C.; Bradway, Dawn M.; Cataldo, Nicholas J.

doi:10.1016/0031-9384(93)90387-u

Cited by 71 publications

(37 citation statements)

References 13 publications

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“…Cumulative food intake was surprisingly similar among all amylin-treated animals, suggesting that amylin may somehow reset food intake to a particular value regardless of food access prior to and during treatment. The effects of other anorexigenic peptides, such as cholecystokinin (CCK), on food intake have been shown to be influenced by changes in endogenous estrogen (2,6). As the present studies did not control for the phase of the estrous cycle, the potential impact of estradiol levels on the efficacy of amylin therapy remains to be elucidated.…”

Section: Discussionmentioning

confidence: 84%

Effects of prior or concurrent food restriction on amylin-induced changes in body weight and body composition in high-fat-fed female rats

Roth¹,

Hughes²,

Coffey³

et al. 2007

American Journal of Physiology-Endocrinology and Metabolism

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Amylin infusion reduces food intake and slows body weight gain in rodents. In obese male rats, amylin (but not pair feeding) caused a preferential reduction of fat mass with protein preservation despite equal body weight loss in amylin-treated (fed ad libitum) and pair-fed rats. In the present study, the effect of prior or concurrent food restriction on the ability of amylin to cause weight loss was evaluated. Retired female breeder rats were maintained on a high-fat diet (40% fat) for 9 wk. Prior to drug treatment, rats were either fed ad libitum or food restricted for 10 days to lose 5% of their starting body weight. They were then subdivided into treatment groups that received either vehicle or amylin (100 μg·kg−1·day−1 via subcutaneous minipump) and placed under either a restricted or ad libitum feeding schedule (for a total of 8 treatment arms). Amylin 1) significantly reduced body weight compared with vehicle under all treatment conditions, except in always restricted animals, 2) significantly decreased percent body fat in all groups, and 3) preserved lean mass in all groups. These results indicate that amylin's anorexigenic and fat-specific weight loss properties can be extended to a variety of nutritive states in female rats.

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Section: Discussionmentioning

confidence: 84%

Effects of prior or concurrent food restriction on amylin-induced changes in body weight and body composition in high-fat-fed female rats

Roth¹,

Hughes²,

Coffey³

et al. 2007

American Journal of Physiology-Endocrinology and Metabolism

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“…Furthermore, with the onset of puberty, estrogen exerts physiological functions including affecting FI regulation and the action of intake regulatory hormones including ghrelin and cholecystokinin (CCK) (27). In rats, estradiol increases CCK's satiating effects (28,29) and attenuates ghrelin's orexigenic effects (30), leading to lower FI. Energy intake is decreased in the follicular compared with the luteal phase of the menstrual cycle because of higher levels of estrogen (31), which may have contributed to the greater reduction in FI in postpubertal girls after glucose.…”

Section: Discussionmentioning

confidence: 99%

Television Viewing at Mealtime Reduces Caloric Compensation in Peripubertal, But Not Postpubertal, Girls

et al. 2011

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ABSTRACT:The effect of television viewing (TVV) and pubertal status of 9-to 14-y-old girls on mealtime food intake (FI) after a premeal glucose drink was determined. On four separate mornings, girls randomly received equally sweetened drinks containing Sucralose (control) or glucose (1.0 g/kg body weight) in 250 mL of water 2 h after a standardized breakfast. FI from an ad libitum pizza meal was measured 30 min later with or without TVV. Appetite was measured at 15 min intervals to lunch and postmeal. TVV at mealtime had no effect on FI, however, glucose suppressed FI more with no TVV compared with TVV (24 versus 10%, p Ͻ 0.001), primarily because of its effect in peripubertal girls (p Ͻ 0.028). In postpubertal girls (n ϭ 8), glucose reduced FI by ϳ27% in both the no TVV and TVV conditions, but in peripubertal girls (n ϭ 17), reduction in FI was 22% without TVV and only 1% while TVV. Appetite correlated with FI at 30 min only in postpubertal girls. TVV at mealtime reduced caloric compensation after consumption of the glucose drink in peripubertal, but not postpubertal, girls, with no effect on mealtime FI. (Clinical trial number NCT01025687.) (Pediatr Res 70: 513-517, 2011) F ood intake (FI) regulation in children is influenced by both physiological and environmental factors. Physiological signals of satiety and satiation are primary regulators of FI and energy balance (1). However, many nonfood-related stimuli in the mealtime environment impact this regulation (2). In children, excessive screen time (4 ϩ h/d) has been associated with increased incidence of obesity (3). Possible causes of this association are increased preference for energy dense foods and sweetened beverages (4), decreased resting metabolic rate (5), meal skipping (6), and reduced activity (7) while television viewing (TVV).Despite the strong associations found between obesity and TVV (7), few studies in children and adolescents have reported quantitative FI while TVV using a within-subject design. Although 3-to 5-y olds eat less while TVV (8), 15-to 16-y olds show no differences in FI when eating while TVV, no TVV, and listening to music (9). Only one study examined the effect of TVV on FI in 9-to 14-y-old children (10). Although TVV, boys ate 24% more at a pizza meal, indicating delayed satiation and showed diminished response to satiety signals after a glucose drink taken 30 min before the meal. Thus, mealtime TVV impaired physiologic signals leading to both satiety and satiation (10).The effect of TVV on satiety and satiation has not been reported for 9-to 14-y-old girls. Girls in this age range experience hormonal changes during puberty that may impact energy intake (11) and may use food and diet to address their negative perceptions of body image (12). Thus, our objective was to investigate the effect of TVV while eating and pubertal status on subjective appetite and mealtime FI 30 min after consumption of glucose (1.0 g/kg body weight) or noncaloric sweetened drink in 9-to 14-y-old girls. Our hypothesis was that TVV reduces the effect of...

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“…Thus, MCH may be added to the growing list of orexigenic (e.g., ghrelin) and anorexigenic (e.g., cholecystokinin, glucagon, serotonin, leptin) compounds that are modulated by estradiol [39][40][41][42][43][44]. An important goal for future research is to determine the relative contribution of each of these compounds to the anorexigenic effect of estradiol.…”

Section: Discussionmentioning

confidence: 99%

The orexigenic effect of melanin-concentrating hormone (MCH) is influenced by sex and stage of the estrous cycle

Santollo

Eckel

2008

Physiology & Behavior

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Recently, it was shown that that the orexigenic effect of melanin concentrating hormone (MCH) is attenuated by estradiol treatment in ovariectomized (OVX) rats. This suggests that female rats may be less responsive than male rats to the behavioral effects of MCH. To investigate this hypothesis, the effects of lateral ventricular infusions of MCH on food intake, water intake, meal patterns, and running wheel activity were examined in male and female rats. To further characterize the impact of estradiol on MCH-induced food intake, female rats were OVX and tested with and without 17-β-estradiol benzoate (EB) replacement. In support of our hypothesis, food and water intakes following MCH treatment were greater in male rats, relative to female rats. Specifically, the orexigenic effect of MCH was maximal in male rats and minimal in EB-treated OVX rats. In both sexes, the orexigenic effect of MCH was mediated by a selective increase in meal size, which was attenuated in EB-treated OVX rats. MCH induced a short-term (2 h) decrease in wheel running that, unlike its effects on ingestive behavior, was similar in males and females. Thus, estradiol decreases some, but not all, of the behavioral effects of MCH. To examine the influence of endogenous estradiol, food intake was monitored following MCH treatment in ovarian-intact, cycling rats. As predicted by our findings in OVX rats, the orexigenic effect of MCH was attenuated in estrous rats, relative to diestrous rats. We conclude that the female rat's reduced sensitivity to the orexigenic effect of MCH may contribute to sex-and estrous cycle-related differences in food intake.

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Modulation of the satiety effect of cholecystokinin by estradiol

Cited by 71 publications

References 13 publications

Effects of prior or concurrent food restriction on amylin-induced changes in body weight and body composition in high-fat-fed female rats

Effects of prior or concurrent food restriction on amylin-induced changes in body weight and body composition in high-fat-fed female rats

Television Viewing at Mealtime Reduces Caloric Compensation in Peripubertal, But Not Postpubertal, Girls

The orexigenic effect of melanin-concentrating hormone (MCH) is influenced by sex and stage of the estrous cycle

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