Modulation of the rat hippocampal‐cortex network and episodic‐like memory performance following entorhinal cortex stimulation

Jiang, Yin; Liu, De‐Feng; Zhang, Xin; Liu, Huan-Guang; Zhang, Chao; Zhang, Jianguo

doi:10.1111/cns.13795

Cited by 7 publications

(5 citation statements)

References 48 publications

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“…Projection neurons in the entorhinal cortex directly formed excitatory synapses on the pyramidal cells of the CA1 area for impulse transmission ( Li et al, 2017 ). Deep brain stimulation of the entorhinal cortex increases dentate gyrus neurogenesis ( Jiang et al, 2022 ). An MRI study ( Lin et al, 2022 ) proved that EA improves cognitive function by increasing the functional connectivity between the entorhinal cortex and hippocampus in mice.…”

Section: Discussionmentioning

confidence: 99%

“…However, the hippocampus is not one of the EA- and MA-activated callback brain areas. In fact, a lot of information from the cortex is projected from the entorhinal cortex to the hippocampus ( Jiang et al, 2022 ). A study reported that entorhinal cortical atrophy in Parkinson’s disease patients with dementia occurs earlier than hippocampal atrophy ( Goldman et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

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Electroacupuncture and manual acupuncture at LR3 and ST36 have attenuating effects on hypertension and subsequent cognitive dysfunction in spontaneously hypertensive rats: A preliminary resting-state functional magnetic resonance imaging study

Liu

Li²,

Yang³

et al. 2023

Front. Neurosci.

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IntroductionChronic hypertension may have a contributory role toward cognitive impairment. Acupuncture exerts protective effects on cognitive functions while controlling the blood pressure. However, the neural mechanism underlying the dual attenuating effect of acupuncture remains unclear. In this study, we investigated the effects of electroacupuncture (EA) and manual acupuncture (MA) on the functional activity of the brain regions of spontaneously hypertensive rats (SHRs) by through resting-state functional magnetic resonance imaging (rs-fMRI). We also evaluated the differences in these functional activities between the EA and MA groups.MethodsWe randomly assigned 30 SHRs into the EA, MA, and model (SHR) groups. Wistar Kyoto rats (n = 10) were used as normal control (WKY). The interventions were administered once every alternate day for 12 weeks. The systolic blood pressure of all rats was recorded every 2 weeks until the end of the intervention. After the intervention, rs-fMRI scanning was performed to access the whole brain data of rats randomly selected from each group evenly. The amplitude of low frequency fluctuation (ALFF) analysis, regional homogeneity (ReHo) analysis, and functional connectivity (FC) analysis were also conducted. The Morris water maze (MWM) test was conducted to evaluate the learning and memory of the rats. Hematoxylin-eosin staining and Nissl staining were performed to observe histopathological changes in the key brain regions.ResultsWe demonstrated that, when compared with the SHR group, the EA and MA groups had significantly lower blood pressure and better performance for behavioral test indices, and that the effect of EA was better than that of MA. ALFF and ReHo analyses revealed enhancement of the neuronal activity of some functionally impaired brain areas in the EA and MA groups. The main callback brain regions included the hypothalamus, entorhinal cortex, brain stem, prelimbic cortex, cingulate cortex, corpus callosum, and cerebellum. The FC analysis demonstrated that EA and MA enhanced the functional connectivity between the seeds and brain regions such as the brain stem, entorhinal cortex, hippocampus, prelimbic cortex, and cerebellum. The pathological test of the entorhinal cortex also verified the protective effect of acupuncture on the neuronal functional activity.DiscussionOur findings suggested that EA and MA exhibited attenuating effects on hypertension and cognitive dysfunction by enhancing the functional activities in the corresponding brain regions. Moreover, EA activated more callback brain regions and functional connectivity than MA, which may explain why the effect of EA was better than that of MA.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Electroacupuncture and manual acupuncture at LR3 and ST36 have attenuating effects on hypertension and subsequent cognitive dysfunction in spontaneously hypertensive rats: A preliminary resting-state functional magnetic resonance imaging study

Liu

Li²,

Yang³

et al. 2023

Front. Neurosci.

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show abstract

“…Multiple indices should be used in future studies to obtain a more objective evaluation. Third, under the premise of meeting the experimental requirements (FJalal et al, 2015;Chen et al, 2017Chen et al, , 2021Li et al, 2018;Jiang et al, 2022), we referred to the relevant literature and only performed the fMRI scans of each group of rats after the experimental acupuncture intervention, and did not perform the fMRI scans of each group of rats before the acupuncture intervention, which might make the experimental data incomplete. In future experiments, we will perform brain scans of each group of rats at baseline to further improve the rigor of the experimental design.…”

Section: Discussionmentioning

confidence: 99%

Acupuncture with twirling reinforcing and reducing manipulation shows a control of hypertension and regulation of blood pressure-related target brain regions in spontaneously hypertensive rat: a preliminary resting-state functional MRI study

Liu

Shi

et al. 2023

Front. Neurosci.

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AimTo observe the effects of acupuncture manipulations on blood pressure and brain function in spontaneously hypertensive rats and elucidate the anti-hypertensive effect of the manipulations’ central mechanism.MethodsThis study used acupuncture twirling reinforcing, acupuncture twirling reducing, and acupuncture twirling uniform reinforcing-reducing manipulations to act on the bilateral TaiChong point of rats. The depth of acupuncture was 1.5–2 mm, and twisting was performed at a frequency of 60 times/min within ±360° for 3 min, followed by the needle being retained for 17 min. Functional magnetic resonance imaging was performed at the end of the intervention. Regional homogeneity and amplitude of low-frequency fluctuations were used to assess the differences in brain regions in each group of rats, and the core brain region (left hypothalamus) among the differential brain regions was selected as the seed for functional connectivity analysis.Results(1) The anti-hypertensive effect was achieved by acupuncture manipulations, and the anti-hypertensive effect of twirling reducing manipulation on spontaneously hypertensive rats was better than that of twirling uniform reinforcing-reducing and twirling reinforcing manipulations. (2) After regional homogeneity and amplitude of low-frequency fluctuations analyses, the hypothalamus, the brain region related to blood pressure, was activated in the twirling uniform reinforcing-reducing manipulation group; the corpus callosum and cerebellum were activated in the twirling reinforcing manipulation group; and the hypothalamus, olfactory bulb, corpus callosum, brainstem, globus pallidum, and striatum were activated in the twirling reducing manipulation group. (3) According to the functional connectivity analysis, different acupuncture manipulations increased the functional connections between seed points and the brainstem, olfactory bulb, and cerebellum, etc.ConclusionThese results suggest that acupuncture manipulations achieved the hypotensive effect and the twirling reducing manipulation had a better hypotensive effect on spontaneously hypertensive rats than twirling uniform reinforcing-reducing and twirling reinforcing manipulations; the central mechanism of the anti-hypertensive effect of twirling reinforcing and reducing manipulation may be related to the activation of brain regions associated with blood pressure regulation and the functional connections between them. Furthermore, brain regions involved in motor control, cognition, and hearing were also activated. We hypothesize that activation of these brain regions may help prevent or mitigate the onset and progression of hypertensive brain damage.

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“…Stimulation of EC induced the activation of prefrontal and hippocampal networks along with improved functional connectivity in various brain regions such as the prefrontal cortex, EC, CA1, CA2 and dentate gyrus as evidenced by functional MRI studies. It also enhanced the episodic-like memory in Sprague-Dawley rats [ 138 ]. Bilateral electrical stimulation of the entorhinal cortex in rats rescued spatial memory deficits and also enhanced markers of long-term potentiation [ 106 ].…”

Section: Deep Brain Stimulation (Dbs) and Alzheimer's Diseasementioning

confidence: 99%

Targeting papez circuit for cognitive dysfunction- insights into deep brain stimulation for Alzheimer's disease

Rapaka,

Tebogo,

Mathew

et al. 2024

Heliyon

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Modulation of the rat hippocampal‐cortex network and episodic‐like memory performance following entorhinal cortex stimulation

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 7 publications

References 48 publications

Electroacupuncture and manual acupuncture at LR3 and ST36 have attenuating effects on hypertension and subsequent cognitive dysfunction in spontaneously hypertensive rats: A preliminary resting-state functional magnetic resonance imaging study

Electroacupuncture and manual acupuncture at LR3 and ST36 have attenuating effects on hypertension and subsequent cognitive dysfunction in spontaneously hypertensive rats: A preliminary resting-state functional magnetic resonance imaging study

Acupuncture with twirling reinforcing and reducing manipulation shows a control of hypertension and regulation of blood pressure-related target brain regions in spontaneously hypertensive rat: a preliminary resting-state functional MRI study

Targeting papez circuit for cognitive dysfunction- insights into deep brain stimulation for Alzheimer's disease

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