2002
DOI: 10.1124/jpet.301.2.441
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Modulation of the Rat Hippocampal Dinucleotide Receptor by Adenosine Receptor Activation

Abstract: Diadenosine pentaphosphate (Ap(5)A) and ATP stimulate an intracellular free calcium concentration ([Ca(2+)](I)) increase in rat hippocampal synaptosomes via different receptors as demonstrated by the lack of cross-desensitization between Ap(5)A and ATP responses. The ATP response was inhibited by P2 receptor antagonists and not by the dinucleotide receptor antagonist, diinosine pentaphosphate (Ip(5)I). In contrast, the Ap(5)A response was inhibited by Ip(5)I but not by P2 receptor antagonists. Studies in singl… Show more

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Cited by 31 publications
(21 citation statements)
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“…Of the four adenosine receptor subtypes, the adenosine A 3 receptor is the most recently cloned [2]. A 3 receptors have a widespread distribution in the rat brain [3] and in the hippocampus are preferentially expressed on nerve terminals [4,5]. The expression of A 3 receptors in the brain is lower than that of other adenosine receptor subtypes [6], and the affinity for adenosine, calculated from binding experiments in rat brain membranes (6.5 μM [2]), is lower than that of A 1 [7] and A 2A [8] receptors.…”
Section: Introductionmentioning
confidence: 99%
“…Of the four adenosine receptor subtypes, the adenosine A 3 receptor is the most recently cloned [2]. A 3 receptors have a widespread distribution in the rat brain [3] and in the hippocampus are preferentially expressed on nerve terminals [4,5]. The expression of A 3 receptors in the brain is lower than that of other adenosine receptor subtypes [6], and the affinity for adenosine, calculated from binding experiments in rat brain membranes (6.5 μM [2]), is lower than that of A 1 [7] and A 2A [8] receptors.…”
Section: Introductionmentioning
confidence: 99%
“…For immunochemical analysis, synaptosomes from striata of male Wistar rats (6 weeks old) and male CD-1 mice (see above) were obtained through a discontinuous Percoll gradient, following the procedure described by Díaz-Hernandez et al (2002), with minor modifications. Striata were homogenized in 0.25 M sucrose and 5 mM N-[tris [hydroxymethyl]methyl]-2-aminoethanesulfonic acid (TES), pH 7.4.…”
Section: Localization Of the Cb 1 Receptor In Rat Striatal Nerve Termmentioning
confidence: 99%
“…For instance, AppCH 2 ppA may be acting through control of the ectoprotein kinase (Ehrlich et al, 1986;Chen et al, 1996). Another mechanism could be the modulation of hippocampal dinucleotide receptors by activation of adenosine receptors, as recently demonstrated in the rat hippocampal synaptosomes (Diaz-Hernandez et al, 2002). Such modulation, demonstrated for diadenosine polyphosphate and adenosine receptors, could reinforce effects of AppCH 2 ppA operating through our suggested pathway.…”
Section: Discussionmentioning
confidence: 94%