Modulation of the neuronal circuitry subserving working memory in healthy human subjects by repetitive transcranial magnetic stimulation

Mottaghy, Felix M.; Krause, Bernd J.; Kemna, Lars J.; Töpper, Rudolf; Tellmann, Lutz; Beu, Markus; Pascual‐Leone, Álvaro; Müller‐Gärtner, Hans‐Wilhelm

doi:10.1016/s0304-3940(00)00798-9

Cited by 135 publications

(93 citation statements)

References 8 publications

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“…The first group of relevant studies [18][19][20][21][22] aimed to verify the hypothesis that the DLPFC plays a crucial role in WM by using the TMS technique. All the studies agree in finding that the DLPFC is involved in the performance of WM tasks, in particular those tasks in which the manipulation of information is required.…”

Section: Wm and Tmsmentioning

confidence: 99%

“…Moreover, Mottaghy and others [20][21][22] investigated the chronometry of the DLPFC involvement in WM and reported how TMS really interferes with the WM task if applied later than 180 ms after the stimulus onset. in fact, they found that the processing of information in WM follows a flow from posterior to anterior regions, and from right to left hemisphere within the PFC [20] .…”

Section: Wm and Tmsmentioning

confidence: 99%

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Dorsolateral prefrontal cortex, working memory and episodic memory processes: insight through transcranial magnetic stimulation techniques

Balconi

2013

Neurosci. Bull.

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The ability to recall and recognize facts we experienced in the past is based on a complex mechanism in which several cerebral regions are implicated. Neuroimaging and lesion studies agree in identifying the frontal lobe as a crucial structure for memory processes, and in particular for working memory and episodic memory and their relationships. Furthermore, with the introduction of transcranial magnetic stimulation (TMS) a new way was proposed to investigate the relationships between brain correlates, memory functions and behavior. The aim of this review is to present the main findings that have emerged from experiments which used the TMS technique for memory analysis. They mainly focused on the role of the dorsolateral prefrontal cortex in memory process. Furthermore, we present state-of-the-art evidence supporting a possible use of TMS in the clinic. Specifically we focus on the treatment of memory deficits in depression and anxiety disorders.

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Section: Wm and Tmsmentioning

confidence: 99%

Section: Wm and Tmsmentioning

confidence: 99%

Dorsolateral prefrontal cortex, working memory and episodic memory processes: insight through transcranial magnetic stimulation techniques

Balconi

2013

Neurosci. Bull.

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“…Generally, rTMS was not expected to suppress the function of the targeted brain region, but rather to modulate its activity to a certain degree, by approximately 15 or 20% if consistent with the findings of similar protocols on cortico-spinal excitability Maeda, Keenan, Tormos, Topka, & Pascual-Leone, 2000a;Romero, Anschel, Sparing, Gangitano, & PREMOTOR ACTIVITY AFTER rTMS 299 Pascual- . In this sense rTMS effects on PFC can be conceived as the result of the ''dynamic'' modulation of multiple afferences and efferences in a complex neuronal network (Mottaghy et al, 2000). …”

Section: Interaction Between Prefrontal and Premotor Corticesmentioning

confidence: 99%

“…Although the suppression of cortico-spinal excitability following low-rate rTMS of the motor cortex in Experiment 3 is consistent with other observations (Chen et al, 1997;Hallett, 2000;Maeda, Keenan, Tormos, Topka, & PascualLeone, 2000b;Pascual-Leone et al, 1999Rothwell, 1991;Walsh & Cowey, 2000) the lack of similar effects in Experiment 2 (when the rTMS was applied to the PMC) is surprising in light of findings that have shown the presence of a robust decrease of cortico-spinal excitability after 1 Hz rTMS to the PMC (Gerschlager, Siebner, & Rothwell, 2001) when intensities of 90% of motor threshold has been employed (Rizzo et al, 2003). Other studies employing low intensities of stimulation (80% MT) on the same premotor spot have shown small or no modulatory effects on MEP amplitude (Mü nchau, Bloem, Trimble, & Rothwell, 2002). It is possible that in our study the relatively short duration of the rTMS train may not have been sufficient to induce a more robust modulation of cortico-spinal excitability.…”

mentioning

confidence: 93%

Release of premotor activity after repetitive transcranial magnetic stimulation of prefrontal cortex

Gangitano

Mottaghy

Pascual‐Leone

2008

Social Neuroscience

Self Cite

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In the present study we aimed to explore by means of repetitive transcranial magnetic stimulation (rTMS) the reciprocal influences between prefrontal cortex (PFC) and premotor cortex (PMC). Subjects were asked to observe on a computer monitor different pictures representing manipulations of different kind of tools. They had to produce a movement (go condition) or to keep the resting position (no-go condition) at the appearance of different cue signals represented by different colors shown alternatively on the hands manipulating the tools or on the picture background. Motor evoked potentials (MEPs) were collected at the offset of the visual stimuli before and after a 10 minute, 1 Hz rTMS train applied to the dorsolateral PFC (Experiment 1), to the PMC (Experiment 2) or to the primary motor cortex (Experiment 3). Following rTMS to the PFC, MEPs increased in the go condition when the cue for the go command was presented on the hand. In contrast, following rTMS to the PMC, in the same condition, MEPs were decreased. rTMS to the primary motor cortex did not produce any modulation. Results are discussed according to the presence of a visual-motor matching system in the PMC and to the role of the PFC in the attention-related processes. We hypothesize that the perceptual analysis for action selection within the PFC was modulated by rTMS and its temporary functional inactivation in turn influenced the premotor areas for motor programming

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“…Motthaghy and colleagues, for example, tested the effect of rTMS on a working memory task and on regional blood flow changes [114]. Repetitive TMS was applied in 30 s trains at a frequency of 4 Hz over the dorsolateral prefrontal cortices (DLPFC) and over the midline frontal cortex as a control site.…”

Section: Tms-pet and Tms-spect Coregistrationmentioning

confidence: 99%

Transcranial Magnetic Stimulation and Neuroimaging Coregistration

Casula¹,

Tarantino²,

Basso³

et al. 2013

Novel Frontiers of Advanced Neuroimaging

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The development of neuroimaging techniques is one of the most impressive advancements in neuroscience. The main reason for the widespread use of these instruments lies in their capacity to provide an accurate description of neural activity during a cognitive process or during rest. This important advancement is related to the possibility to selectively detect changes of neuronal activity in space and time by means of different biological markers. Specifically, functional magnetic resonance imaging (fMRI), positron emission tomography (PET), single-photon emission computed tomography (SPECT), and nearinfrared spectroscopy (NIRS) use metabolic markers of ongoing neuronal activity to provide an accurate description of the activation of specific brain areas with high spatial resolution. Similarly, electroencephalography (EEG) is able to detect electric markers of neuronal activity, providing an accurate description of brain activation with high temporal resolution. The application of these techniques during a cognitive task allows important inferences regarding the relation between the detected neural activity, the cognitive process involved in an ongoing task, and behaviour: this is known as a “correlational approach”

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Modulation of the neuronal circuitry subserving working memory in healthy human subjects by repetitive transcranial magnetic stimulation

Cited by 135 publications

References 8 publications

Dorsolateral prefrontal cortex, working memory and episodic memory processes: insight through transcranial magnetic stimulation techniques

Dorsolateral prefrontal cortex, working memory and episodic memory processes: insight through transcranial magnetic stimulation techniques

Release of premotor activity after repetitive transcranial magnetic stimulation of prefrontal cortex

Transcranial Magnetic Stimulation and Neuroimaging Coregistration

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