Modulation of the immune system by melatonin; implications for cancer therapy

Moslehi, Masoud; Moazamiyanfar, Reza; Dakkali, Mohammad Sedigh; Rezaei, Sepideh; Rastegar-Pouyani, Nima; Jafarzadeh, Emad; Mouludi, Kave; Khodamoradi, Ehsan; Taeb, Shahram; Najafi, Masoud

doi:10.1016/j.intimp.2022.108890

Cited by 31 publications

(11 citation statements)

References 142 publications

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“…Some immune responses may boost toxicity in normal tissue and lessen the effectiveness of anti-cancer treatments. Conversely, manipulating immune responses may increase anti-tumor therapy’s efficacy and reduce the toxicity experienced by normal tissue [ 23 ]. Chemotherapeutic and immunotherapeutic medications influence all tissues.…”

Section: Cancer and The Role Of The Immune Systemmentioning

confidence: 99%

Nanomaterials-Based Novel Immune Strategies in Clinical Translation for Cancer Therapy

et al. 2023

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Immunotherapy shows a lot of promise for addressing the problems with traditional cancer treatments. Researchers and clinicians are working to create innovative immunological techniques for cancer detection and treatment that are more selective and have lower toxicity. An emerging field in cancer therapy, immunomodulation offers patients an alternate approach to treating cancer. These therapies use the host’s natural defensive systems to identify and remove malignant cells in a targeted manner. Cancer treatment is now undergoing somewhat of a revolution due to recent developments in nanotechnology. Diverse nanomaterials (NMs) have been employed to overcome the limits of conventional anti-cancer treatments such as cytotoxic, surgery, radiation, and chemotherapy. Aside from that, NMs could interact with live cells and influence immune responses. In contrast, unexpected adverse effects such as necrosis, hypersensitivity, and inflammation might result from the immune system (IS)’s interaction with NMs. Therefore, to ensure the efficacy of immunomodulatory nanomaterials, it is essential to have a comprehensive understanding of the intricate interplay that exists between the IS and NMs. This review intends to present an overview of the current achievements, challenges, and improvements in using immunomodulatory nanomaterials (iNMs) for cancer therapy, with an emphasis on elucidating the mechanisms involved in the interaction between NMs and the immune system of the host.

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Section: Cancer and The Role Of The Immune Systemmentioning

confidence: 99%

Nanomaterials-Based Novel Immune Strategies in Clinical Translation for Cancer Therapy

et al. 2023

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“…2,3 Melatonin is involved in various physiological functions such as antioxidation, antiinflammation, and immunomodulation. [4][5][6] In addition, melatonin has a potential oncostatic effect on a variety of cancer cells and tissues through anti-metastatic, anti-proliferative, and pro-apoptotic mechanisms. 7,8 Melatonin is also synthesized and metabolized in the liver.…”

Section: Introductionmentioning

confidence: 99%

“…Melatonin, a derivative of tryptophan, is a neurohormone initially isolated from the bovine pineal gland 1 that is widely distributed in body tissues including the gastrointestinal tract 2,3 . Melatonin is involved in various physiological functions such as antioxidation, anti‐inflammation, and immunomodulation 4–6 . In addition, melatonin has a potential oncostatic effect on a variety of cancer cells and tissues through anti‐metastatic, anti‐proliferative, and pro‐apoptotic mechanisms 7,8 …”

Section: Introductionmentioning

confidence: 99%

Dietary melatonin and liver cancer incidence in Japan: From the Takayama study

Wada,

Hattori,

Maruyama

et al. 2024

Cancer Science

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There is some biological plausibility that exogenous melatonin plays a role in preventing liver carcinogenesis. There has been little research on the association between melatonin intake in a normal diet and health outcomes. We evaluated the association between dietary melatonin intake and the incidence of liver cancer in a population‐based prospective study in Japan. This study included 30,824 residents of Takayama city who were 35 years of age or older in 1992 and had participated in the Takayama study, Japan. Dietary intake was assessed using a validated food frequency questionnaire at the baseline. Melatonin content in foods was measured by liquid chromatography–tandem mass spectrometry. Cancer incidence was confirmed through regional population‐based cancer registries in Gifu. Liver cancer was defined as code C22 according to the International Classification of Diseases and Related Health Problems, 10th Revision. Hazard ratios for liver cancer were estimated for the tertile groups of melatonin intake using a Cox proportional hazards model. During the mean follow‐up period of 13.6 years, 189 individuals developed liver cancer. Compared with subjects in the lowest tertile of melatonin intake, those in the middle and highest tertiles had decreased risks of liver cancer, with a significant linear trend after multivariate adjustments (hazard ratios: 0.64 and 0.65, respectively, trend p = 0.023). There was no significant interaction by sex (interaction p = 0.54). This initial finding, which needs to be confirmed by further studies, suggests that consuming melatonin‐containing foods might play a role in the prevention of liver cancer.

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“…Modulation or shifting immune responses is an intriguing approach that may help with amelioration of normal tissue side effects caused by anticancer drugs and radiotherapy, and also augment tumour responses to therapy. Employing natural products is a potential approach for shifting immune responses in both tumour and normal tissues 21–24 . This review focuses on immunoregulatory actions of resveratrol as a natural product in both tumour and normal organs.…”

Section: Introductionmentioning

confidence: 99%

“…Employing natural products is a potential approach for shifting immune responses in both tumour and normal tissues. [21][22][23][24] This review focuses on immunoregulatory actions of resveratrol as a natural product in both tumour and normal organs.…”

Section: Introductionmentioning

confidence: 99%

Immunoregulation by resveratrol; implications for normal tissue protection and tumour suppression

Lalani

Fakhari

Radgoudarzi

et al. 2023

Clin Exp Pharma Physio

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Immune reactions are involved in both tumour and normal tissue in response to therapy. Elevated secretion of certain chemokines, exosomes and cytokines triggers inflammation, pain, fibrosis and ulceration among other normal tissue side effects. On the other hand, secretion of tumour-promoting molecules suppresses activity of anticancer immune cells and facilitates the proliferation of malignant cells. Novel anticancer drugs such as immune checkpoint inhibitors (ICIs) boost anticancer immunity via inducing the proliferation of anticancer cells such as natural killer (NK) cells and CD8+ T lymphocytes. Certain chemotherapy drugs and radiotherapy may induce anticancer immunity in the tumour, however, both have severe side effects for normal tissues through stimulation of several immune responses. Thus, administration of natural products with low side effects may be a promising approach to modulate the immune system in both tumour and normal organs. Resveratrol is a well-known phenol with diverse effects on normal tissues and tumours. To date, a large number of experiments have confirmed the potential of resveratrol as an anticancer adjuvant. This review focuses on ensuing stimulation or suppression of immune responses in both tumour and normal tissue after radiotherapy or anticancer drugs. Later on, the immunoregulatory effects of resveratrol in both tumour and normal tissue following exposure to anticancer agents will be discussed.

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Modulation of the immune system by melatonin; implications for cancer therapy

Cited by 31 publications

References 142 publications

Nanomaterials-Based Novel Immune Strategies in Clinical Translation for Cancer Therapy

Nanomaterials-Based Novel Immune Strategies in Clinical Translation for Cancer Therapy

Dietary melatonin and liver cancer incidence in Japan: From the Takayama study

Immunoregulation by resveratrol; implications for normal tissue protection and tumour suppression

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