Modulation of the Blood–Brain Barrier by Sigma-1R Activation
Eugen Brailoiu,
Jeffrey L. Barr,
Hailey N. Wittorf
et al.
Abstract:Sigma non-opioid intracellular receptor 1 (Sigma-1R) is an intracellular chaperone protein residing on the endoplasmic reticulum at the mitochondrial-associated membrane (MAM) region. Sigma-1R is abundant in the brain and is involved in several physiological processes as well as in various disease states. The role of Sigma-1R at the blood–brain barrier (BBB) is incompletely characterized. In this study, the effect of Sigma-1R activation was investigated in vitro on rat brain microvascular endothelial cells (RB… Show more
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