Abstract:Background: Alzheimer’s disease (AD) is a neurodegenerative disorder
characterized by the accumulation of hyperphosphorylated tau (p-tau) in
neurofibrillary tangles and beta-amyloid plaques. The role of oxidative
stress (OS) in AD progression remains unclear. Methods: Using SH-SY5Y
human neuroblastoma cells as an in vitro model, we investigated the
impact of OS on tau phosphorylation. Mature neurons were exposed to
varying concentrations of hydrogen peroxide for different durations (1-5
days) to simulate OS. W… Show more
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