Modulation of synaptic plasticity by brain estrogen in the hippocampus

Mukai, Hideo; Kimoto, Tsunenobu; Hojo, Yasushi; Kawato, Suguru; Murakami, Gen; Higo, Shimpei; Hatanaka, Yusuke; Ogiue-Ikeda, Mari

doi:10.1016/j.bbagen.2009.11.002

Cited by 128 publications

(108 citation statements)

References 102 publications

Supporting

Mentioning

100

Contrasting

Unclassified

Order By: Relevance

“…In this brain area, estradiol induces the formation of excitatory synapses, increases dendritic spine density, synaptic plasticity, and prolongs excitatory postsynaptic potentials in CA1 pyramidal cells (Rudick and Woolley, 2001;Murakami et al, 2006;Mukai et al, 2010). Differences in nuclear estradiol uptake was detected in CA1 and CA3, observing a majority of labeled cells in the ventral horn of CA3 .…”

Section: Discussionmentioning

confidence: 96%

“…Interestingly, the local synthesis of E2 in the female hippocampus has been described and reaches levels of $0.5-2 nM (Mukai et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Results are expressed as the mean AE SD. Paired comparisons were as follows: *P < 0.05 versus E and D; **P < 0.05 versus P; þ P < 0.05 versus P, E, and M. Recently, it has been reported that E2 is synthesized de novo in hippocampal neurons and that this hippocampal-derived E2 is essential for synaptic plasticity (Mukai et al, 2010). In addition, it has been demonstrated that both ER isoforms are expressed in the hippocampus, and that ERa is upregulated in culture hippocampal cells (Rune and Frostscher, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…At current, functions of E2 in hippocampus are attracting much attention as hippocampus-derived E2 seems to play a major role in the modulation of synaptic plasticity (Mukai et al, 2010). Additionally, it is well known that there are at least two types of estrogen receptors (ERs); ERa and ERb, which have different transcriptional activity (Matthews and Gustafsson, 2003;Milner et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…This evidence suggests that each ER subtypes should play a different role in the regulation of hippocampal function, not only slow (gene transcriptional) but also rapid (kinase driving) E2 signaling pathways (Mukai et al, 2010) as propposed by Walf (2010).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Differential Expression of Estrogen Receptors in Two Hippocampal Regions During the Estrous Cycle of the Rat

Mendoza-Garcés

Mendoza-Rodríguez

Jiménez-Trejo

et al. 2011

The Anatomical Record

View full text Add to dashboard Cite

In the hippocampus, estrogens increase dendritic arborization, longterm potentiation, neuroprotection, and participate in many functions related with learning, memory, and affective behaviors. The presence of both estrogen receptors alpha (ERa) and beta (ERb) isoforms has been described in the hippocampus where they play different physiological roles. The aim of this study was to investigate, by using both techniques immunohistochemistry and Western Blot, the expression pattern of ERa and ERb in the hippocampus of the rat along the estrous cycle. Western blot analysis was used to confirm the specificity of the antibodies used against ERa and ERb and its relative content in the hippocampus. Results from immunohistochemical studies indicate that ERb expression increased more than the ERa in CA1 and CA3 regions during all phases of the estrous cycle. ERb immunoreactivity was mainly located in the nucleus and predominantly expressed in CA1 during estrous and metestrus, and in CA3 during diestrus. ERa was more abundant during estrous in comparison to other phases of the cycle in CA1 region, while it was more abundant during metestrus in CA3. Interestingly, the immunolocalization of ERa subtype was both cytoplasmic and nuclear. The overall results indicate that there is a differential expression, cellular localization, and distribution of both ER subtypes in CA1 and CA3 regions, suggesting different roles for these two receptors in the hippocampus along the estrous cycle. Anat Rec, 294:1913Rec, 294: -1919Rec, 294: , 2011. V V C 2011 Wiley-Liss, Inc.

show abstract

Section: Discussionmentioning

confidence: 96%

“…Interestingly, the local synthesis of E2 in the female hippocampus has been described and reaches levels of $0.5-2 nM (Mukai et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Differential Expression of Estrogen Receptors in Two Hippocampal Regions During the Estrous Cycle of the Rat

Mendoza-Garcés

Mendoza-Rodríguez

Jiménez-Trejo

et al. 2011

The Anatomical Record

View full text Add to dashboard Cite

show abstract

Gonadal Steroid Hormones and Brain Protection

Singh¹,

Brock²,

Cunningham³

et al. 2017

Gene Regulation, Epigenetics and Hormone Signaling

View full text Add to dashboard Cite

Progesterone receptor expression in cajal‐retzius cells of the developing rat dentate gyrus: Potential role in hippocampus‐dependent memory

Newell

Lalitsasivimol

Willing

et al. 2018

J of Comparative Neurology

View full text Add to dashboard Cite

The development of medial temporal lobe circuits is critical for subsequent learning and memory functions later in life. The present study reports the expression of progesterone receptor (PR), a powerful transcription factor of the nuclear steroid receptor superfamily, in Cajal-Retzius cells of the molecular layer of the dentate gyrus of rats. PR was transiently expressed from the day of birth through postnatal day 21, but was absent thereafter. Although PR immunoreactive (PR-ir) cells did not clearly express typical markers of mature neurons, they possessed an ultrastructural morphology consistent with neurons. PRir cells did not express markers for GABAergic neurons, neuronal precursor cells, nor radial glia. However, virtually all PR cells co-expressed the calcium binding protein, calretinin, and the glycoprotein, reelin, both reliable markers for Cajal-Retzius neurons, a transient population of developmentally critical pioneer neurons that guide synaptogenesis of perforant path afferents and histogenesis of the dentate gyrus. Indeed, inhibition of PR activity during the first two weeks of life impaired adult performance on both the novel object recognition and object placement memory tasks, two behavioral tasks hypothesized to describe facets of episodic-like memory in rodents. These findings suggest that PR plays an unexplored and important role in the development of hippocampal circuitry and adult memory function.

show abstract

Modulation of synaptic plasticity by brain estrogen in the hippocampus

Cited by 128 publications

References 102 publications

Differential Expression of Estrogen Receptors in Two Hippocampal Regions During the Estrous Cycle of the Rat

Differential Expression of Estrogen Receptors in Two Hippocampal Regions During the Estrous Cycle of the Rat

Gonadal Steroid Hormones and Brain Protection

Progesterone receptor expression in cajal‐retzius cells of the developing rat dentate gyrus: Potential role in hippocampus‐dependent memory

Contact Info

Product

Resources

About