Modulation of Synaptic Plasticity by Vibratory Training in Young and Old Mice

Cariati, Ida; Bonanni, Roberto; Pallone, Gabriele; Annino, Giuseppe; Tancredi, Virginia; D’Arcangelo, Giovanna

doi:10.3390/brainsci11010082

Cited by 15 publications

(29 citation statements)

References 36 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our previous work, we reported that exposure to an appropriate WBV protocol improves learning and memory processes in old mice (Cariati et al, 2021). These brain functions are particularly susceptible to the aging process.…”

Section: Discussionmentioning

confidence: 94%

“…Vibration training was conducted using three protocols (A, B, and C), which differ in terms of vibration frequency and exposure time to vibration (Cariati et al, 2021). The A and B protocols consisted of five series (consecutive number of repetitions) of 3 min each, interspersed with 1 min of recovery.…”

Section: Training Protocolsmentioning

confidence: 99%

“…The C protocol consisted of three series of 2 min and 30 s each, with a recovery period of equal duration. The vibration frequency used was 90 Hz for the A protocol and 45 Hz for B and C protocols (Cariati et al, 2021). The animals underwent a total of 36 days of activity; specifically, each group of mice was trained for 12 weeks, on a 3-weekly basis.…”

Section: Training Protocolsmentioning

confidence: 99%

“…Based on these considerations, in our previous work we evaluated the effects of three WBV training protocols, differing in vibration frequency and vibration exposure time, on synaptic plasticity in an experimental mouse model, by means of in vitro extracellular recordings in hippocampal slices from 4to 24-month-old mice (Cariati et al, 2021). It was previously suggested that synaptic plasticity is positively affected by WBV training, both in rodents (Manthou et al, 2017) and in humans (Fuermaier et al, 2014;Regterschot et al, 2014), probably through the involvement of sensory stimulation leading to cognitive enhancement.…”

Section: Introductionmentioning

confidence: 99%

“…In agreement with these studies, our results showed that WBV training can modulate synaptic plasticity differently, depending on the protocol used, and that the best effects are related to the training protocol characterized by a low vibration frequency and a longer recovery time. Surprisingly, 24-month-old mice exposed to mechanical vibrations showed full recovery of cognitive capacity (Cariati et al, 2021), suggesting that vibratory training may be considered an important factor in protecting and/or preventing the development of age-related cognitive disorders, which in turn is closely related to synaptic plasticity (Weber et al, 2015;De Domenico et al, 2017). It is well known that aging is a biological process associated with physiological cognitive decline, as it can impair quality of life and cause deficits in memory and learning processes (Bettio et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Dose–Response Effect of Vibratory Stimulus on Synaptic and Muscle Plasticity in a Middle-Aged Murine Model

et al. 2021

Self Cite

View full text Add to dashboard Cite

Whole body vibration plays a central role in many work categories and can represent a health risk to the musculoskeletal system and peripheral nervous system. However, studies in animal and human models have shown that vibratory training, experimentally and/or therapeutically induced, can exert beneficial effects on the whole body, as well as improve brain functioning and reduce cognitive decline related to the aging process. Since the effects of vibratory training depend on several factors, such as vibration frequency and vibration exposure time, in this work, we investigated whether the application of three different vibratory protocols could modulate synaptic and muscle plasticity in a middle-aged murine model, counteracting the onset of early symptoms linked to the aging process. To this end, we performed in vitro electrophysiological recordings of the field potential in the CA1 region of mouse hippocampal slices, as well as histomorphometric and ultrastructural analysis of muscle tissue by optic and transmission electron microscopy, respectively. Our results showed that protocols characterized by a low vibration frequency and/or a longer recovery time exert positive effects at both hippocampal and muscular level, and that these effects improve significantly by varying both parameters, with an action comparable with a dose–response effect. Thus, we suggested that vibratory training may be an effective strategy to counteract cognitive impairment, which is already present in the early stages of the aging process, and the onset of sarcopenia, which is closely related to a sedentary lifestyle. Future studies are needed to understand the underlying molecular mechanisms and to determine an optimal vibratory training protocol.

show abstract

Section: Discussionmentioning

confidence: 94%

Section: Training Protocolsmentioning

confidence: 99%

Section: Training Protocolsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Dose–Response Effect of Vibratory Stimulus on Synaptic and Muscle Plasticity in a Middle-Aged Murine Model

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

Whole body vibration ameliorates anxiety-like behavior and memory functions in 30 months old senescent male rats

Oroszi,

Felszeghy,

Luiten

et al. 2024

Heliyon

View full text Add to dashboard Cite

Whole-body vibration ameliorates glial pathological changes in the hippocampus of hAPP transgenic mice, but does not affect plaque load

et al. 2023

View full text Add to dashboard Cite

Background Alzheimer’s disease (AD) is the core cause of dementia in elderly populations. One of the main hallmarks of AD is extracellular amyloid beta (Aβ) accumulation (APP-pathology) associated with glial-mediated neuroinflammation. Whole-Body Vibration (WBV) is a passive form of exercise, but its effects on AD pathology are still unknown. Methods Five months old male J20 mice (n = 26) and their wild type (WT) littermates (n = 24) were used to investigate the effect of WBV on amyloid pathology and the healthy brain. Both J20 and WT mice underwent WBV on a vibration platform or pseudo vibration treatment. The vibration intervention consisted of 2 WBV sessions of 10 min per day, five days per week for five consecutive weeks. After five weeks of WBV, the balance beam test was used to assess motor performance. Brain tissue was collected to quantify Aβ deposition and immunomarkers of astrocytes and microglia. Results J20 mice have a limited number of plaques at this relatively young age. Amyloid plaque load was not affected by WBV. Microglia activation based on IBA1-immunostaining was significantly increased in the J20 animals compared to the WT littermates, whereas CD68 expression was not significantly altered. WBV treatment was effective to ameliorate microglia activation based on morphology in both J20 and WT animals in the Dentate Gyrus, but not so in the other subregions. Furthermore, GFAP expression based on coverage was reduced in J20 pseudo-treated mice compared to the WT littermates and it was significantly reserved in the J20 WBV vs. pseudo-treated animals. Further, only for the WT animals a tendency of improved motor performance was observed in the WBV group compared to the pseudo vibration group. Conclusion In accordance with the literature, we detected an early plaque load, reduced GFAP expression and increased microglia activity in J20 mice at the age of ~ 6 months. Our findings indicate that WBV has beneficial effects on the early progression of brain pathology. WBV restored, above all, the morphology of GFAP positive astrocytes to the WT level that could be considered the non-pathological and hence “healthy” level. Next experiments need to be performed to determine whether WBV is also affective in J20 mice of older age or other AD mouse models.

show abstract

Modulation of Synaptic Plasticity by Vibratory Training in Young and Old Mice

Cited by 15 publications

References 36 publications

Dose–Response Effect of Vibratory Stimulus on Synaptic and Muscle Plasticity in a Middle-Aged Murine Model

Dose–Response Effect of Vibratory Stimulus on Synaptic and Muscle Plasticity in a Middle-Aged Murine Model

Whole body vibration ameliorates anxiety-like behavior and memory functions in 30 months old senescent male rats

Whole-body vibration ameliorates glial pathological changes in the hippocampus of hAPP transgenic mice, but does not affect plaque load

Contact Info

Product

Resources

About