Modulation of steroidogenic gene expression and hormone synthesis in H295R cells exposed to PCP and TCP

Ma, Yanbo; Liu, Chunsheng; Wu, Rudolf S.S.; Giesy, John P.; Hecker, Markus; Zhang, Xiaowei; Zhou, Bingsheng

doi:10.1016/j.tox.2011.01.024

Cited by 33 publications

(11 citation statements)

References 58 publications

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“…Interestingly, the literature concerning five of these non-mutagens (2,4,6-Trichlorophenol, Butyl benzyl phthalate, Hydroquinone, Mirex, and Furan) had data classified in the category of hormonal receptor-mediated effects. This result is also in line with what is known about some of these compounds (Ma et al, 2011; Upson et al, 2013; Alam and Kurohmaru, 2016). …”

Section: Resultssupporting

confidence: 91%

Combining QSAR Modeling and Text-Mining Techniques to Link Chemical Structures and Carcinogenic Modes of Action

Papamokos

Silins

2016

Front. Pharmacol.

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There is an increasing need for new reliable non-animal based methods to predict and test toxicity of chemicals. Quantitative structure-activity relationship (QSAR), a computer-based method linking chemical structures with biological activities, is used in predictive toxicology. In this study, we tested the approach to combine QSAR data with literature profiles of carcinogenic modes of action automatically generated by a text-mining tool. The aim was to generate data patterns to identify associations between chemical structures and biological mechanisms related to carcinogenesis. Using these two methods, individually and combined, we evaluated 96 rat carcinogens of the hematopoietic system, liver, lung, and skin. We found that skin and lung rat carcinogens were mainly mutagenic, while the group of carcinogens affecting the hematopoietic system and the liver also included a large proportion of non-mutagens. The automatic literature analysis showed that mutagenicity was a frequently reported endpoint in the literature of these carcinogens, however, less common endpoints such as immunosuppression and hormonal receptor-mediated effects were also found in connection with some of the carcinogens, results of potential importance for certain target organs. The combined approach, using QSAR and text-mining techniques, could be useful for identifying more detailed information on biological mechanisms and the relation with chemical structures. The method can be particularly useful in increasing the understanding of structure and activity relationships for non-mutagens.

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Section: Resultssupporting

confidence: 91%

Combining QSAR Modeling and Text-Mining Techniques to Link Chemical Structures and Carcinogenic Modes of Action

Papamokos

Silins

2016

Front. Pharmacol.

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“…Therefore, exposure to TCPs can occur through ingestion of food and water. A recent study indicated that TCPs may reduce testosterone levels by disrupting cAMP signaling [14].…”

Section: Introductionmentioning

confidence: 99%

Interactions between Urinary 4-tert-Octylphenol Levels and Metabolism Enzyme Gene Variants on Idiopathic Male Infertility

Qin

Chen

et al. 2013

PLoS ONE

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Octylphenol (OP) and Trichlorophenol (TCP) act as endocrine disruptors and have effects on male reproductive function. We studied the interactions between 4-tert-Octylphenol (4-t-OP), 4-n- Octylphenol (4-n-OP), 2,3,4-Trichlorophenol (2,3,4-TCP), 2,4,5-Trichlorophenol (2,4,5-TCP) urinary exposure levels and polymorphisms in selected xenobiotic metabolism enzyme genes among 589 idiopathic male infertile patients and 396 controls in a Han-Chinese population. Ultra high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was used to measure alkylphenols and chlorophenols in urine. Polymorphisms were genotyped using the SNPstream platform and the Taqman method. Among four phenols that were detected, we found that only exposure to 4-t-OP increased the risk of male infertility (P trend = 1.70×10−7). The strongest interaction was between 4-t-OP and rs4918758 in CYP2C9 (P inter = 6.05×10−7). It presented a significant monotonic increase in risk estimates for male infertility with increasing 4-t-OP exposure levels among men with TC/CC genotype (low level compared with non-exposed, odds ratio (OR) = 2.26, 95% confidence intervals (CI) = 1.06, 4.83; high level compared with non-exposed, OR = 9.22, 95% CI = 2.78, 30.59), but no associations observed among men with TT genotype. We also found interactions between 4-t-OP and rs4986894 in CYP2C19, and between rs1048943 in CYP1A1, on male infertile risk (P inter = 8.09×10−7, P inter = 3.73×10−4, respectively).We observed notable interactions between 4-t-OP exposure and metabolism enzyme gene polymorphisms on idiopathic infertility in Han-Chinese men.

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“…Because of their toxicity and adverse effects on humans and wildlife, the US EPA classified PCP and TCP as priority pollutants [2]. Some countries have banned or controlled the use of PCP [3], but other countries still use PCP to prevent fungal attacks on wood [4]. PCP was used in China during the 1970s to control schistosomiasis [5], and large concentrations of PCP (up to 103.7 μg/L) were detected in Dongting Lake [6].…”

Section: Introductionmentioning

confidence: 99%

“…PCP was banned in China as a pesticide in 1997 [7]; however, PCP is still used as a wood preservative [6]. Concentrations of PCP as great as 0.59 μg/L, 2,4-dichlorophenol (DCP) as great as 20.0 μg/L and TCP as great as 29.0 μg/L were observed in the surface water of seven major watersheds and three drainage areas of China [4,8].…”

Section: Introductionmentioning

confidence: 99%

Comparative proteomic analysis of ovary for Chinese rare minnow (Gobiocypris rarus) exposed to chlorophenol chemicals

Fang¹,

Gao

Zhao

et al. 2014

Journal of Proteomics

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Modulation of steroidogenic gene expression and hormone synthesis in H295R cells exposed to PCP and TCP

Cited by 33 publications

References 58 publications

Combining QSAR Modeling and Text-Mining Techniques to Link Chemical Structures and Carcinogenic Modes of Action

Combining QSAR Modeling and Text-Mining Techniques to Link Chemical Structures and Carcinogenic Modes of Action

Interactions between Urinary 4-tert-Octylphenol Levels and Metabolism Enzyme Gene Variants on Idiopathic Male Infertility

Comparative proteomic analysis of ovary for Chinese rare minnow (Gobiocypris rarus) exposed to chlorophenol chemicals

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