Modulation of Stem Cells as Therapeutics for Severe Mental Disorders and Cognitive Impairments

Zhang, Yongbo; Zhao, Yingying; Song, Xiaopeng; Luo, Hanqi; Sun, Jiayi; Han, Chao; Gu, Xiaohuan; Li, Jun; Cai, Guilan; Zhu, Yanbing; Liu, Zhandong; Wei, Ling; Wei, Zheng

doi:10.3389/fpsyt.2020.00080

Cited by 18 publications

(13 citation statements)

References 82 publications

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“…The transplantation of NSCs into the transgenic AD mice model has shown a significant increase in the mitochondrial number and expression of mitochondria-related proteins. This has improved the cognitive function in a mouse model (Zhang et al 2020 ). Human NSCs have been tried to treat AD in transgenic animal models (Li et al 2016 ; Blurton-Jones et al 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Hippocampus and its involvement in Alzheimer’s disease: a review

et al. 2022

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Hippocampus is the significant component of the limbic lobe, which is further subdivided into the dentate gyrus and parts of Cornu Ammonis. It is the crucial region for learning and memory; its sub-regions aid in the generation of episodic memory. However, the hippocampus is one of the brain areas affected by Alzheimer’s (AD). In the early stages of AD, the hippocampus shows rapid loss of its tissue, which is associated with the functional disconnection with other parts of the brain. In the progression of AD, atrophy of medial temporal and hippocampal regions are the structural markers in magnetic resonance imaging (MRI). Lack of sirtuin (SIRT) expression in the hippocampal neurons will impair cognitive function, including recent memory and spatial learning. Proliferation, differentiation, and migrations are the steps involved in adult neurogenesis. The microglia in the hippocampal region are more immunologically active than the other regions of the brain. Intrinsic factors like hormones, glia, and vascular nourishment are instrumental in the neural stem cell (NSC) functions by maintaining the brain’s microenvironment. Along with the intrinsic factors, many extrinsic factors like dietary intake and physical activity may also influence the NSCs. Hence, pro-neurogenic lifestyle could delay neurodegeneration.

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Section: Introductionmentioning

confidence: 99%

Hippocampus and its involvement in Alzheimer’s disease: a review

et al. 2022

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“…54 EIF3G is involved in apoptosis and has been associated with neuropsychiatric disorders. 55,56 ELAVL1 is a potential target for miR-9, and it plays a critical role in the progression of inflammation. 57 EXOSC7 is found upregulated expression in animal models of stroke.…”

Section: Discussionmentioning

confidence: 99%

Identification of Dysregulated Mechanisms and Potential Biomarkers in Ischemic Stroke Onset

Feng¹,

Meng²,

Zhou³

et al. 2021

IJGM

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“…It is increasingly appreciated that defects in both neurons and glia underlie the pathogenesis of brain diseases. Deficits in myelinogenesis and neuronal function contribute to distinct aspects of the complex etiology of SCZ [188,189]. Interestingly, association between single nucleotide polymorphisms in miR-219-1 and miR-137, which are crucial for oligodendroglia and neuronal lineage development, respectively, has been reported in a SCZ cohort [190].…”

Section: Mirnas In Glial Cells and Glia-neuron Communication Implicatmentioning

confidence: 99%

Multifaceted Regulation of MicroRNA Biogenesis: Essential Roles and Functional Integration in Neuronal and Glial Development

Suster

Feng

2021

IJMS

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MicroRNAs (miRNAs) are small, non-coding RNAs that function as endogenous gene silencers. Soon after the discovery of miRNAs, a subset of brain-enriched and brain-specific miRNAs were identified and significant advancements were made in delineating miRNA function in brain development. However, understanding the molecular mechanisms that regulate miRNA biogenesis in normal and diseased brains has become a prevailing challenge. Besides transcriptional regulation of miRNA host genes, miRNA processing intermediates are subjected to multifaceted regulation by canonical miRNA processing enzymes, RNA binding proteins (RBPs) and epitranscriptomic modifications. Further still, miRNA activity can be regulated by the sponging activity of other non-coding RNA classes, namely circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs). Differential abundance of these factors in neuronal and glial lineages partly underlies the spatiotemporal expression and function of lineage-specific miRNAs. Here, we review the continuously evolving understanding of the regulation of neuronal and glial miRNA biogenesis at the transcriptional and posttranscriptional levels and the cooperativity of miRNA species in targeting key mRNAs to drive lineage-specific development. In addition, we review dysregulation of neuronal and glial miRNAs and the detrimental impacts which contribute to developmental brain disorders.

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Modulation of Stem Cells as Therapeutics for Severe Mental Disorders and Cognitive Impairments

Cited by 18 publications

References 82 publications

Hippocampus and its involvement in Alzheimer’s disease: a review

Hippocampus and its involvement in Alzheimer’s disease: a review

Identification of Dysregulated Mechanisms and Potential Biomarkers in Ischemic Stroke Onset

Multifaceted Regulation of MicroRNA Biogenesis: Essential Roles and Functional Integration in Neuronal and Glial Development

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