Modulation of sialic acid levels among some organs during insulin resistance or hyperglycemic states

Abstract

Previous studies have suggested a possible connection between insulin resistance and chronic hyperglycemia with membrane sialic acid content. In this study, the effects of high (20% ad libitum) fructose and glucose feeding on the sialic acid levels of some organs were investigated in rats. The blood glucose levels of the high fructose- and glucose-fed rats were consistently and significantly (P < 0.05) higher than the normal control throughout the experiment. Free serum sialic acid and total hepatic sialic acid levels were elevated in the high fructose- and glucose-fed rats compared to normal control, but only the data for the high glucose-fed group were significantly (P < 0.05) different from the normal control. Conversely, a significant (P < 0.05) decrease in the pancreatic sialic acid level was observed in high glucose-fed group compared to normal control. Also, the high fructose-fed rats had lower, but insignificant (P > 0.05), pancreatic sialic acid level than the normal control. On the other hand, high fructose and glucose feeding did not significantly (P > 0.05) affect the sialic acid levels of the skeletal muscle and heart, though a tendency to increase the sialic acid level was evident in the heart. In the kidney, the sialic acid level was significantly (P < 0.05) increased in both high fructose- and glucose-fed groups. It was concluded that the liver and kidney tend to stimulate sialic acid synthesis, while the pancreas downregulate sialic acids synthesis and/or promote sialic acid release from glycoconjugates. Also, these organs may contribute to high-serum sialic acid level observed during diabetes.

Biochemical markers decrease and increase disproportionally in A1 pulley tissue of type 2 diabetic trigger finger patients

“…Although we found decreased tissue SA levels, details on the modulation of SA metabolism between various organs under insulin resistance or chronic hyperglycemic conditions are insufficient. In their experimental study, Ibrahim et al [38] found decreased pancreatic SA levels in high-glucosefed rats when compared to the healthy group, but high fructose and glucose feeding did not affect SA levels in the muscle and heart. In the kidney and liver, they observed significantly increased SA levels in both the high-fructose and glucose feeding groups.…”

Mini Review: Oxazolidinone and Other Sialic Acid C5 Modifications Over the Past Decade

“…In diabetic rat liver, increased expression of monosialogangliosides GM1 and GM3, disialoganglioside GD1b and trisialoganglioside GT1b, with a marked absence of GM2 were found (Sanchez et al, 2000;Abregu et al, 2002). Rats subjected under a high fructose and glucose diet showed elevated sialic acid synthesis in the liver and kidney with concomitant loss of sialic acids in the pancreas (Ibrahim et al, 2016).…”

Oxidative stress and changes in liver sialoglycoconjugate metabolic parameters in rats with alloxanic diabetes mellitus

“…Некоторые ингибиторы сиалидазы могут являться глюкозозависимым усилителем секреции инсулина [10]. При алиментарной гипергликемии у крыс наблюдалось повышение содержания СК в сыворотке крови [11].…”