Modulation of serotonin binding in rat brain by membrane fluidity

Pharmacological and Physicochemical Properties of Pre‐Versus Postsynaptic 5‐Hydroxytryptamine1A Receptor Binding Sites in the Rat Brain: A Quantitative Autoradiographic Study

“…Previous studies already focused on the relevance of lipidprotein interactions for the integrity of 5-HT1 receptors. Thus, changes in the membrane fluidity due to the incorporation of various lipids in brain membranes have been reported to alter the specific binding of [3H]5-HT (Heron et al, 1980;Wesemann et al, 1986;Von Hungen et al, 1987). As shown in the present study, the effect of PLA2 on 5-HTiA sites exhibited some regional variations (Table 3).…”

Subacute exposure to low concentrations of toluene affects dopamine-mediated locomotor activity in the rat

“…Thus, it seems as if changes in membrane fluidity [20,47) cannot fully explain the effects of toluene exposure in vivo on D-2 receptor binding even though the affinity of D-2 agonist binding sites are similarly reduced by in vivo and in vitro treatment [20,21), as is the modulation of D-2 agonist binding sites by neurotensin in vitro [21). Furthermore, it should be recalled that the effects of toluene in vivo on the D-2 receptor can be inhibited by injections once daily with the endogenous ganglioside GM 1 [20] which stabilizes membrane fluidity [23).…”

Alterations in Serotonin Parameters in Brain of Thiamine‐Deficient Rats Are Evident Prior to the Appearance of Neurological Symptoms

“…1996). This finding may relate to the present increases in number of I 3H I ketanserin binding sites given that changes in membrane fluidity due to the incorporation of various lipids have been reported to alter the specific binding of 13H15-HT (Heron et al, 1980;Weseman et al, 1986). It is interesting that a modest transient increase in affinity I as demonstrated by a decrease in K 11 (Table 3)1 was observed in Irontocortical tissue, perhaps further reflecting a change in membrane properties.…”