Modulation of seizure-like events by the small conductance and ATP-sensitive potassium ion channels

Soboleva, Elena B.; Amakhin, Dmitry V.; Sinyak, Denis S.; Zaitsev, Aleksey V.

doi:10.1016/j.bbrc.2022.07.057

Cited by 6 publications

(1 citation statement)

References 26 publications

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“…Modulators of SK channel subtypes can be used to treat many diseases due to their different effects. For instance, NS309 promotes endothelial protection [24]; chlorzoxazone improves motor coordination [25]; DCEBIO reduces the number of evoked spikes, the firing frequency and increases the afterhyperpolarizing potential of infralimbic neurons, suggesting the potential use of SK channels modulators to treat patients with anxiety disorders [26]; 1-EBIO decreases epileptiform activity and positively affects cerebral ischemia [27,28], while riluzole improves symptoms related to cerebellar ataxia [29] and significantly reduces acute arthritis [30]. On the other hand, apamin acts by inhibiting SK channels.…”

Section: Classification Of Sk Channelsmentioning

confidence: 99%

Presence of Small-Conductance Calcium-Activated Potassium (SK) Channels in the Central and Peripheral Nervous Systems and Their Role in Health and Disease

DosSantos¹,

Filha²,

Veríssimo³

et al. 2023

J. Integr. Neurosci.

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Potassium (K + ) channels establish and maintain the resting potential of most living cells. Their activity is predominantly regulated by the membrane voltage or the K + gradient across the cell membrane. However, many cells also express small-conductance calciumactivated potassium (SK) channels, which have the unique ability to translate changes in the level of the intracellular second messenger, Ca 2+ to changes in the membrane K + conductance and, therefore, the resting membrane potential. This article reviews the structure, presence, distribution, and function of SK channels, their pharmacological modulation, and their role in health and disease, emphasizing nociception and pain.

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