Modulation of Restraint Induced Gastric Oxidative Changes in Rats by Tocotrienol and Tocopherol

Azlina, Mohd Fahami Nur; Rubaizah, K.; Muliana, M. Siti; Nafeeza, Mohd Ismail

doi:10.3923/ijp.2009.58.64

Cited by 10 publications

(17 citation statements)

References 25 publications

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“…Supplementations of vitamin E such as tocopherol and tocotrienol have been shown to reduce the formation of SIGMI as reported in previous studies [10,28]. The findings were observed in the study by Ibrahim et al which showed a significant reduction in mean gastric lesions in rats supplemented with PVE and α-tocopherol (60 mg/kg body weight for 28 days) [7].…”

Section: Discussionsupporting

confidence: 69%

“…This dose was chosen based on previous studies which had reported protective effects of tocotrienol and tocopherol on stress-induced gastric mucosal injury [9,10,15]. The DeltaGold 70 used in this study was in the form of 70% viscous tocotrienol material).…”

Section: Methodsmentioning

confidence: 99%

“…Supplementation with vitamin E such as α-tocopherol and mixed tocotrienol isomers protects the gastric mucosa against stress-induced injury. It was also postulated that tocotrienol possesses a better protective effect compared with tocopherol and this was related to a decrease in lipid peroxidation, restoration of glutathione peroxidase enzyme levels and also increased gastric prostaglandin E 2 [7,10,13]. Furthermore, the δ-tocotrienol form of tocotrienol was found to be more potent than the γ-and α-tocotrienol forms [14].…”

Section: Introductionmentioning

confidence: 99%

“…The assessment of severity of gastric lesions was done based on a modified semi-quantitative scale [10]. The severity of gastric lesions was assessed macroscopically by two independent examiners who were blinded to the treatment that the rats received.…”

Section: Assessment Of Gastric Lesionsmentioning

confidence: 99%

“…Furthermore, it has been postulated that the oxygen-derived free radicals and lipid peroxidation are involved in the pathogenesis of SIGMI [10]. In addition, the development of SIGMI may be enhanced by factors such as impairment of gastric microcirculation, increased lipid peroxidation and increased pro-inflammatory cytokines and other mediators such as prostaglandin E2 [11].…”

Section: Introductionmentioning

confidence: 99%

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Pure tocotrienol concentrate protected rat gastric mucosa from acute stress-induced injury by a non-antioxidant mechanism

Rodzian¹,

Ibrahim²,

Azlina³

2013

pjp

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Stress has been implicated as a risk factor of various major health problems, such as stress-induced gastric mucosal injury. This study was performed to investigate the action of a pure preparation of tocotrienol (T3) concentrate, made up of 90% δ-tocotrienol and 10% γ-tocotrienol, on gastric injury of rats induced by water-immersion restraint stress (WIRS). Fourteen male Sprague-Dawley rats (200-250 g) were divided into two equal groups: a control group and a treated group. The treatment group received T3 concentrate at 60 mg/kg body weight daily for 28 days. The body weights of rats were recorded daily before the treatment was given. At the end of the treatment period, all rats were subjected to WIRS for 3.5 hours, following which the rats were euthanized. The stomachs were isolated and opened along the greater curvature for the examination of lesions and measurements of gastric malondialdehyde (MDA) and prostaglandin E 2 (PGE 2 ) contents. The mean gastric mucosal lesion index in the treated rats was significantly lower than that in the control rats. This suggests that the T3 concentrate has the ability to confer protection to the gastric mucosa against gastric injury induced by acute stress. No significant difference was observed for changes in body weight before and after the treatment. The gastric PGE 2 content in both groups was comparable. However, the gastric MDA content was significantly higher in the treated group compared to the control group, indicating that the T3 supplementation was not able to reduce the lipid peroxidation process. This study concludes that the T3 concentrate has the ability to protect the gastric mucosa from stress-induced injury by a non-antioxidant mechanism.

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Section: Discussionsupporting

confidence: 69%

Section: Methodsmentioning

confidence: 99%