Modulation of renshaw cell activity during scratching

Delyagina, T. G.; Feldman, Anatol G.

doi:10.1007/bf01078565

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…First, they contain the lateral cervical nucleus (relay for ascending spinocervicothalamic tract fibres). Second, a model of fictive scratch can be created in the decerebrate/spinal cat by application of tubocurarine to the dorsal surface of the cervical cord at C1 (and to a lesser extent C2) and then rubbing the pinna and the skin behind the ear [ 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

MRI characteristics for “phantom” scratching in canine syringomyelia

Nalborczyk¹,

McFadyen²,

Jovanovik³

et al. 2017

BMC Vet Res

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BackgroundA classic sign of canine syringomyelia (SM) is scratching towards one shoulder. Using magnetic resonance imaging (MRI) we investigate the spinal cord lesion relating to this phenomenon which has characteristics similar to fictive scratch secondary to spinal cord transection.Medical records were searched for Cavalier King Charles spaniels with a clinical and MRI diagnosis of symptomatic SM associated with Chiari-like malformation (CM). The cohort was divided into SM with phantom scratching (19 dogs) and SM but no phantom scratching (18 dogs). MRI files were anonymised, randomised and viewed in EFILM ™. For each transverse image, the maximum perpendicular dimensions of the syrinx in the dorsal spinal cord quadrants were determined. Visual assessment was made as to whether the syrinx extended to the superficial dorsal horn (SDH).ResultsWe showed that phantom scratching appears associated with a large dorsolateral syrinx that extends to the SDH in the C3-C6 spinal cord segments (corresponding to C2-C5 vertebrae). Estimated dorsal quadrant syrinx sizes based on the perpendicular diameters were between 2.5 and 9.5 times larger in dogs with phantom scratching, with the largest mean difference p-value being 0.009.ConclusionSM associated phantom scratching appears associated with MRI findings of a large syrinx extending into the mid cervical SDH. We hypothesise that damage in this region might influence the lumbosacral scratching central pattern generator (CPG). If a scratching SM affected dog does not have a large dorsolateral cervical syrinx with SDH involvement then alternative explanations for scratching should be investigated.Electronic supplementary materialThe online version of this article (10.1186/s12917-017-1258-2) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%