Modulation of red blood cell population dynamics is a fundamental homeostatic response to disease

Patel, Harsh; Patel, Hemi; Higgins, John M.

doi:10.1002/ajh.23982

Cited by 89 publications

(103 citation statements)

References 34 publications

(84 reference statements)

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“…The increased RDW values in cardiovascular disorders is related to the triggering of the erythropoiesis by erythropoietin. On the other hand, elevated RDW values may be affected from RBC turnover (17,18). More recently, some authors mentioned that the higher values of the RDW is a bad prognostic factor in patients with cardiac diseases (19).…”

Section: Introductionmentioning

confidence: 99%

Remarkable Hematological Laboratory Findings in Patients with Fibromyalgia Syndrome

Sayılır¹

2016

Tod

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ÖzAmaç: Çalışmamızda ortalama trombosit hacmi (OTH) ve eritrosit dağılım genişliği (EDG) değerleri ile beraber bazı laboratuvar bulgularının Fibromiyalji sendromu (FMS) ile ilişkisi incelendi. Çalışmamız FMS'de OTH ve EDG değerlerinin beraber değerlendirildiği ilk çalışma olma özelliğini taşımaktadır. Gereç ve Yöntem: Çalışmaya hipertansiyonu, hiperkolesterolemisi veya diyabeti, kronik enflamatuvar hastalıkları, trombotik hastalık öyküsü veya antikoagülan tedavi kullanımı olmayan ve vücut kitle indeksleri 30 kg/m 2 'nin altında olan 36 FMS hastası ve 36 kişilik kontrol grubu dahil edildi. Bilgisayar tabanlı yazılımlarla retrospektif olarak veriler incelendi. Bulgular: Çalışmaya dahil edilen 36 FMS hastasının yaş ortalamaları 44,6, kontrol grubunun yaş ortalaması 42,5 olarak bulundu. Hemoglobin, hematokrit, ortalama eritrosit hacmi, platelet sayısı, EDG, OTH değerleri gruplar arasında istatistiksel anlamlı fark göstermedi. Öte yandan EDG değerlerinin iki grup arasında sınırda istatistiksel anlam taşıdığı görüldü. Sonuç: Çalışmamız sonucunda, OTH değerlerinin gruplar arasında istatistiksel fark göstermemesine rağmen EDG değerlerinin sınıra yakın istatistiksel fark göstermesinin akılda tutulmasının, klinik pratikte faydalı olacağı kanaati oluşmuştur. Anahtar kelimeler: Fibromiyalji sendromu, hematolojik bulgular, eritrosit dağılım genişliği Remarkable Hematological Laboratory Findings in Patients with Fibromyalgia Syndrome Fibromiyalji Sendromunda Dikkat Çeken Hematolojik Laboratuvar DeğerleriObjective: In our study, we examined the role of mean platelet volume (MPV) and red blood cell distribution width (RDW) values with certain laboratory findings in Fibromyalgia syndrome (FMS). This study is the first study which evaluates the relationship between MPV and RDW values in FMS patients. Materials and Methods:The study consisted of two groups; study group (n=36; FMS patients) and control group (n=36). Patients not having hypertension, hypercholesterolaemia or diabetes, chronic inflammatory disease, history of thrombotic disease or not receiving anticoagulant agents, and as well as patients having body mass index of <30 kg/m 2 were included in the study. Data were examined via computer-based software programs, retrospectively. Results: The study population consisted of 36 female FMS patients and 36 female control individuals. The mean ages of the patients in FMS and control groups were 44.6 years 42.5 years, respectively. There were not significant statistical differences between the groups in terms of hemoglobin levels, hematocrit levels, mean erythrocyte volume, platelet count, and RDW and MPV values. On the other hand, the RDW values were found to be statistically significant between the groups. Conclusion:The present study demonstrated that MPV levels were not significantly higher between the groups; however, statistically significant values of RDW might be considered in clinical practice.

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Section: Introductionmentioning

confidence: 99%

Remarkable Hematological Laboratory Findings in Patients with Fibromyalgia Syndrome

Sayılır¹

2016

Tod

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“…With an epidemiologic design, this study cannot determine biological mechanisms but can provide some hints to inform biological investigations searching for the mechanisms. Variations in RBC sizes measured by the numerator of RDW and by the clearance rate of RBCs were previously reported to be associated with prognosis (21,25). It was hypothesized that RDW elevation may result due to a greater %Micro (25), %Macro (23), or both (21).…”

Section: L I N I C a L M E D I C I N Ementioning

confidence: 99%

“…Variations in RBC sizes measured by the numerator of RDW and by the clearance rate of RBCs were previously reported to be associated with prognosis (21,25). It was hypothesized that RDW elevation may result due to a greater %Micro (25), %Macro (23), or both (21). This study confirms that it is all 3 (see Figure 5), showing that having concomitantly higher %Macro and higher %Micro is the highest risk condition across all morbidities and for mortality, with elevation of one or the other having an intermediate level of risk.…”

Section: L I N I C a L M E D I C I N Ementioning

confidence: 99%

Extreme erythrocyte macrocytic and microcytic percentages are highly predictive of morbidity and mortality

Horne¹,

Bennett²,

Muhlestein³

et al. 2018

JCI Insight

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IntroductionFor more than 80 years, the degree of anisocytosis has been recognized as a useful characteristic for differentiating types of anemia (1). Measured as the coefficient of variation of RBC size, the addition of the red cell distribution width (RDW) to the complete blood count (CBC) around 1980 brought the evaluation of anemia types and the early diagnosis of iron deficiency anemia into routine practice (2, 3). The discovery BACKGROUND. The red cell distribution width (RDW) is associated with health outcomes. Whether non-RDW risk information is contained in RBC sizes is unknown. This study evaluated the association of the percentage of extreme macrocytic RBCs (%Macro, RBC volume > 120 fl) and microcytic RBCs (%Micro, RBC volume < 60 fl) and the RDW-size distribution (RDW-sd) with mortality and morbidity.

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“…As well as mortality, in these patients increased RDW has been shown to predict advanced stage and worse prognosis (15). In a prospective, observational cohort study including 1,840 patients with solid and hematological cancer included in the prospective study named Vienna Cancer and Thrombosis Study (CATS), high RDW was found associated with an increased risk of mortality with an HR per 1% RDW increase of 1.11 (95% CI, 1.08-1.15, P<0.001).…”

Section: Introductionmentioning

confidence: 99%

Red cell distribution width and cancer

2016

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Red cell distribution width (RDW) is an index which primarily reflects impaired erythropoiesis and abnormal red blood cell survival. In last years the interest in this marker has considerably grown and now a lot of data are available indicating that this simple and inexpensive parameter is a strong and independent risk factor for death in the general population. Moreover, several investigations have been performed to investigate the role of RDW in cardiovascular and thrombotic disorders. Contrarily, there are relatively few reports focusing on RDW in the area of oncology and to date none review have been performed in this specific field. As such, the aim of this narrative review is to summarize some interesting results obtained in studies performed in patients affected by solid and hematological tumors. Even if larger studies are needed before these preliminary findings can be generalized, it seems plausible to affirm that RDW can be useful by adding prognostic information in patients with oncologic disease.

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Modulation of red blood cell population dynamics is a fundamental homeostatic response to disease

Cited by 89 publications

References 34 publications

Remarkable Hematological Laboratory Findings in Patients with Fibromyalgia Syndrome

Remarkable Hematological Laboratory Findings in Patients with Fibromyalgia Syndrome

Extreme erythrocyte macrocytic and microcytic percentages are highly predictive of morbidity and mortality

Red cell distribution width and cancer

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