Modulation of pulmonary immune function by inhaled cannabis products and consequences for lung disease

Abstract

The lungs, in addition to participating in gas exchange, represent the first line of defense against inhaled pathogens and respiratory toxicants. Cells lining the airways and alveoli include epithelial cells and alveolar macrophages, the latter being resident innate immune cells important in surfactant recycling, protection against bacterial invasion and modulation of lung immune homeostasis. Environmental exposure to toxicants found in cigarette smoke, air pollution and cannabis can alter the number and function of immune cells in the lungs. Cannabis (marijuana) is a plant-derived product that is typically inhaled in the form of smoke from a joint. However, alternative delivery methods such as vaping, which heats the plant without combustion, are becoming more common. Cannabis use has increased in recent years, coinciding with more countries legalizing cannabis for both recreational and medicinal purposes. Cannabis may have numerous health benefits owing to the presence of cannabinoids that dampen immune function and therefore tame inflammation that is associated with chronic diseases such as arthritis. The health effects that could come with cannabis use remain poorly understood, particularly inhaled cannabis products that may directly impact the pulmonary immune system. Herein, we first describe the bioactive phytochemicals present in cannabis, with an emphasis on cannabinoids and their ability to interact with the endocannabinoid system. We also review the current state-of-knowledge as to how inhaled cannabis/cannabinoids can shape immune response in the lungs and discuss the potential consequences of altered pulmonary immunity. Overall, more research is needed to understand how cannabis inhalation shapes the pulmonary immune response to balance physiological and beneficial responses with potential deleterious consequences on the lungs.

Case report: Cannabinoid therapy for discoid lupus erythematosus in a dog

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Comprehensive Safety Assessment of Diverse Cannabinoids: A Scientific Inquiry

“…Understanding the consequences of inhaled cannabis products on lung cells is crucial for discerning their therapeutic potential and potential risks. It necessitates comprehensive research to elucidate the intricate mechanisms underlying the modulation of pulmonary immune responses, providing insights that can inform the development of targeted interventions and therapeutic strategies for lung diseases associated with cannabis use [11]. Testing on Human Hepatocytes is also important to identify or observe any complications to liver cells from consumption of cannabinoids.…”