Modulation of Primary and Secondary Processes in Tau Fibril Formation by Salt-Induced Dynamics
Arshad Abdul Vahid,
Muhammed Shafeek Oliyantakath Hassan,
Allwin Ebenezer Sahayaraj
et al.
Abstract:The initial stages of amyloid fibrilization begin with the monomers populating aggregation-prone conformers. Characterization of such aggregation-prone conformers is crucial in the study of neurodegenerative diseases. The current study characterizes the aggregation pathway of two tau protein constructs that have been recently demonstrated to form Alzheimer's (AD) fibril structures with divalent ions and chronic traumatic encephalopathy (CTE) fibril structures with monovalent ions. The results highlight the inv… Show more
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