Modulation of Postoperative Scarring with Tacrolimus and Octreotide in Experimental Glaucoma Filtration Surgery

Improving patient outcomes following glaucoma surgery: state of the art and future perspectives

“…A variety of alternative antiscarring strategies (Table 1), such as photodynamic therapy,101–104 saratin (Merck KGaA),105,106 sonepcizumab (Lpath, Inc., San Diego, CA, USA),107 doxycycline (Pfizer Inc.),108 pirfenidone (InterMune, Brisbane, CA, USA),109,110 tacrolimus (Astellas Pharma Inc., Tokyo, Japan),111 and octreotide (Novartis),111 have also shown promising results by improving the outcome of surgery in a standard rabbit model. Although many agents have been evaluated in preclinical models for glaucoma filtration surgery, few have been found to be beneficial in large prospective comparative clinical trials and none have replaced mitomycin C or 5-fluorouracil in clinical practice so far.…”

Fibrosis Suppression Therapy in Failed Filtering Blebs After Trabeculectomy: Results of Early Period

“…25 Arslan et al found that topically administration of Tacrolimus and Octreotide effectively reduced the subconjuntival scarring response 2 weeks after experimental glaucoma filtration surgery. 26 In a comparative study with Interceed and Surgicel, Akyol and Akpolat 27 observed that both these agents seem to suppress vascularization but they have no significant effect on fibroblast proliferation. In our study, we studied the effect of oral steroid, nonsteroid antiinflamatuar drug (NSAID) and Colchicine on bleb vascularization.…”

“…[25][26][27] The next intervention is a minimally invasive reparative surgery of the filtering bleb by transconjunctival needle revision in case of ineffectivity. 23,24,26 Finally, if filtration is still inadequate, an invasive reparative surgery of the filtering bleb or another filtering procedure at a new location may be required.…”

“…[25][26][27] The next intervention is a minimally invasive reparative surgery of the filtering bleb by transconjunctival needle revision in case of ineffectivity. 23,24,26 Finally, if filtration is still inadequate, an invasive reparative surgery of the filtering bleb or another filtering procedure at a new location may be required. 25,28,29 Bleb appearance is related with intraocular pressure control, but overall success of glaucoma surgery depends on more than just the final intraocular pressure.…”

Efeito do ácido rosmarínico sobre parâmetros cicatriciais relacionados à cirurgia antiglaucomatosa experimental

“…Diante dessas dificuldades e da necessidade de novas opções de drogas moduladoras da cicatrização, a quantidade de estudos visando a descoberta de novos fármacos para o tratamento adjuvante em cirurgias filtrantes do glaucoma vem crescendo nos últimos anos, abrindo perspectiva para a pesquisa de novos agentes moduladores (ARSLAN et al, 2012;LÜKE et al, 2010;LUKOWSKI et al, 2013;MIN et al, 2012b;RIBEIRO, 2011;TURGUT et al, 2014TURGUT et al, , 2015ZHONG et al, 2011).…”