Modulation of platelet thromboxane A2 and arterial prostacyclin by dietary vitamin E

Karpen, C.W.; Merola, Aristide; Trewyn, Ronald W.; Cornwell, David G.; Panganamala, R.V.

doi:10.1016/0090-6980(81)90074-5

Cited by 101 publications

(25 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The vascular generation of prostacyclin (PGI 2 ) is higher and the platelet thromboxane A 2 generation is lower than normal. This view is supported by the findings of Steiner and Anastasi (1976) and others (Karpen et al, 1981;Pritchard et al, 1982;Pignatelli et al, 1999) that vitamin E inhibits platelet thromboxane A 2 synthesis. On the other hand, PGI 2 synthesis is stimulated possibly by reduction of cellular peroxide level (Gilbert et al, 1983).…”

Section: Resultssupporting

confidence: 76%

Myocardial Ischemia-Reperfusion/Injury

Saleh¹,

Youssef²

2012

Novel Strategies in Ischemic Heart Disease

View full text Add to dashboard Cite

Section: Resultssupporting

confidence: 76%

Myocardial Ischemia-Reperfusion/Injury

Saleh¹,

Youssef²

2012

Novel Strategies in Ischemic Heart Disease

View full text Add to dashboard Cite

“…These results suggest that the reduction of vitamin E in platelets may lead to an enhancement of prostaglandin metabolism and consequently platelet aggregation in diabetics. Karpen et al observed that low platelet vitamin E causes an increase in thromboxane production in diabetic rats (Karpen et al 1982), and that animals fed a vitamin E-rich diet also show reduced platelet aggregation (Karpen et al 1981). In vitro addition of vitamin E to human PRP inhibits platelet aggregation (Fong 1976;Steiner and Anastasi 1976).…”

Section: Discussionmentioning

confidence: 99%

“…The following chemicals were purchased from commercial sources : Adenosine diphosphate (ADP) (Boehringer-Mennheim, Germany) ; DL-a-Tocopherol (Nakarai Chemicals, Kyoto) ; [5,6,8,9,11,12,14,15] 3H-thromboxane B2 (New England Nuclear, USA). Authentic thrombexane B2 and thromboxane B2 antibody were generous gifts from Ono pharmaceuticals (Osaka).…”

Section: Methodsmentioning

confidence: 99%

“…It has been reported that in vitro vitamin E addition to human platelet rich plasma causes reduced platelet aggregation (Fong 1976;Steiner and Anastasi 1976). The inhibitory effect on platelet aggregation was also demonstrated in animals supplemented with vitamin E (Karpen et al 1981). However, there has been no report concerning the pathophysiology of vitamin E metabolism in diabetic platelets related to aggregation and prostaglandin metabolism.…”

mentioning

confidence: 98%

See 1 more Smart Citation

Effect of vitamin E on platelet aggregation in diabetes mellitus.

Watanabe

Umeda

Wakasugi

et al. 1984

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Vitamin E is known to be an inhibitor of platelet prostaglandin production and aggregation. The rate of platelet aggregation induced by adenosine diphosphate was significantly increased in diabetics with proliferative retinopathy, and the enhanced production of thromboxane B2i a stable metabolite of thromboxane A2, was demonstrated in those patients. On the other hand, vitamin E was significantly reduced in platelets obtained from diabetics as compared to age matched control subjects. In addition, it was shown that vitamin E content in platelets examined in diabetic and control subjects inversely correlated with both the rate of platelet aggregation and thromboxane B2 production during aggregation. It is suggested that the reduced vitamin E levels in diabetic platelets can contribute to the mechanisms of the enhanced platelet thromboxane A2 production and aggregation which lead to the development of vascular complications. vitamin E ; platelet aggregation ; thromboxane B2 ; diabetic retinopathy

show abstract

“…Damage to vascular endothelial cells induced by glucose may lead to diabetic vascular complications. As Karpen et al [9] demonstrated that a reduction in arterial PGI2 production by diabetic rats can be restored by administering vitamin E, we conducted the present in vitro study to determine if vitamin E would also restore the glucose-induced reduction of vascular endothelial cell replication.…”

Section: Discussionmentioning

confidence: 99%