Modulation of Plasma and Tissue Kallikreins in Psoriasis vulgaris and Psoriasis pustulosa

Evaluation of Different Treatment Methods in Patients with Psoriasis and Content of Kallikrein and Kallikreinogen in Blood Plasma

“…Its involvement and activation with the progress of psoriasis has been observed in preliminary investigations by different authors [1][2][3]. The aim of this study was to investigate the relationship of changes in the kallikrein-kinin system induced by andecalin and dilminal-D and the clinical course of psoriasis.…”

B1 and B2 kinin receptor blockade improves psoriasis‐like disease

“…Interactions of kinins with the constitutive bradykinin B 2 receptors or with the inducible bradykinin B 1 receptors have been implicated in many physiological and pathological processes, including vasodilation and release of inflammatory mediators (Calixto et al, 2004;Seliga et al, 2018). Several studies have shown that kinins are released during tissue trauma or injury and following inflammatory responses, with increased levels in diseases such as lupus, cancer, and psoriasis (Costa-neto et al, 2008;Dutra, 2017;Poblete et al, 1991;Schremmer-Danninger, Hermann, Fink, Fritz, & Roscher, 1999;Segawa et al, 2009). However, only a few studies support the role of kinins in cutaneous disorders (Poblete et al, 1991;Schremmer-Danninger et al, 1999;Sharma & Al-Sherif, 2006).…”