Modulation of phosphoinositide turnover by chronic nicergoline in rat brain

Effects of nicergoline treatment on regional cerebral blood flow in early Alzheimer's disease

“…Moreover, nicergoline may exert a positive effect on the neuronal signal transduction system by stimulating the phosphoinositide pathway, which has been reported to be impaired in AD . Nicergoline may also increase protein kinase C (PKC) translocation, which combats beta‐amyloid deposition, and slow down the reduction of nerve growth factor, which may help in preventing cholinergic neuron loss . Other possible actions of nicergoline include enhancement of dopaminergic and noradrenergic turnover, promotion of cerebral metabolic activity, and neuroprotection …”

“…29 Nicergoline may also increase protein kinase C (PKC) translocation, which combats beta-amyloid deposition, and slow down the reduction of nerve growth factor, which may help in preventing cholinergic neuron loss. 5,[34][35][36] Other possible actions of nicergoline include enhancement of dopaminergic and noradrenergic turnover, 37 promotion of cerebral metabolic activity, 38,39 and neuroprotection. [40][41][42] Some limitations of this study should be addressed.…”

Altered Neurotransmission and Signal Transduction: Targets for Nicergoline Treatment

“…Furthermore, in synaptosomes, nicer goline stimulates a dose-dependent increase in the trans location of PKC to the cell membrane, particularly its aand P-isoenzymes [13]. 4 Dement These biochemical effects of nicergoline have behav ioral correlates in animals.…”

Protein Kinase C in Synaptic Plasticity: A Molecular Target in the Treatment of Cognitive Disorders

“…However, nicergoline also exerts a protective effect following hypoxia, even in hy percapnic conditions, when cerebral blood vessels are already dilated, suggesting that its effects might be due to a direct action on brain parenchyma [46], It has been shown that intracisternal administration of nicergoline influences both blood pressure and heart rate in anaesthetized dogs [47] and inhibits T-and L-type neu ronal Ca2+ channels [48]. Moreover, nicergoline enhances basal and receptor-stimulated turnover of phosphatidyli nositol after both acute and chronic treatments in selected brain regions [49]. These findings prompted us to investi gate whether nicergoline could affect PKC translocation in vitro and in vivo in areas of rat brain.…”