Modulation of Phase II Enzymes by Organosulfur Compounds from Allium Vegetables in Rat Tissues

Potential of Diallyl Sulfide Bearing pH-Sensitive Liposomes in Chemoprevention Against DMBA-Induced Skin Papilloma

“…All the formulations of DAS (250 µg) were applied within one hour after exposure with DMBA three times a week for 12 weeks. The animals were divided into nine groups each comprising 15 …”

Allyl sulfur compounds and cellular detoxification system: effects and perspectives in cancer therapy

“…However, DADS does not significantly influence the activities of TST in tumorbearing mice (Iciek et al 2005). Recently, we have found Hu et al (1996); 14 Dragnev et al (1995); 15 Sheen et al (1999); 16 Dwivedi et al(1996); 17 Guyonnet et al (1999); 18 Andorfer et al (2004); 19 Demeule et al (2004); 20 Iciek et al (2005); 21 Wu et al (2001); 22 Hatono et al (1996); 23 Sumiyoshi and Wargovich (1990); 24 Sabelli et al 2008 that garlic-derived 2-PTS is able to interact with the active site of the rhodanese enzyme inducing thiolation of the catalytic cysteine, forming a characteristic disulfide bond which is not cleavable by a nucleophilic attack of cyanide (Sabelli et al 2008). A significant reduction of TST activity has been observed during 2-PTS treatments indicating that cyanide detoxification of rhodanese is reduced by the presence of 2-PTS.…”

“…Diallyl sulfur compounds from garlic and onion have been reported to increase also the activity of the phase II detoxification enzymes NAD(P)H: quinone oxidoreductase 1 (NQO1) and GSTs in a variety of rat tissues (Guyonnet et al 1999;Munday and Munday 1999;Singh et al 1998). The administration of DAS, DADS, and DATS in human hepatoma HepG2 cells induces changes in the transcriptional levels of NQO1 and heme oxygenase 1 (HO 1) genes (Chen et al 2004;Fukao et al 2004).…”

“…GSTs are also involved in the metabolism of several types of anticancer drugs (Tew 1994) and are overexpressed in many human persistent tumors (Tsuchida and Sato 1992). Chemopreventive effects of garlic constituents are associated with increased levels of GSH and with both significant increase of GST activity in rats treated with DADS (Demeule et al 2004) and increased levels of GSTa and GSTp in kidney (Dwivedi et al 1996;Guyonnet et al 1999). It has been also observed that the stimulation of hepatic GST by OSCs may require quite a long lag time to evidence an effect (Sumiyoshi and Wargovich 1990;Sparnins et al 1986Sparnins et al , 1988.…”

A novel autofluorescence-based selection of calli amenable to Agrobacterium-mediated transformation in onion (Allium cepa L.)

“…As a consequence of reduced LFS enzyme activity, more of the 1-PS produced from PRENCSO breakdown is expected to be diverted to thiosulfinate formation. The thiosulfinates and their derivatives have been reported to have antiasthmatic, antithrombotic, and anticancer effects (Block et al 1997;Dorsch et al 1989;Guyonnet et al 1999). They are also associated with the characteristic flavor of onion (Randle 1997).…”