Modulation of Perception or Emotion? A Scoping Review of Tinnitus Neuromodulation Using Transcranial Direct Current Stimulation

Shekhawat, Giriraj Singh; Stinear, Cathy M.; Searchfield, Grant D.

doi:10.1177/1545968314567152

Cited by 31 publications

(35 citation statements)

References 67 publications

(237 reference statements)

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“…The assessment of symptom change is further complicated by the dependence on subjective questionnaires due to a lack of objective measures for tinnitus reduction. Finally, as the involvement of multiple brain areas, in particular the TPA and DLPFC ( Shekhawat et al, 2015c ), in tinnitus hampers the prediction of tES related changes, a combination of stimulation and neuroimaging techniques such as EEG or fMRI can be useful to explore the physiological basis of tES for the treatment of tinnitus ( Vanneste and De Ridder, 2011 ; Vanneste et al, 2011 ; De Ridder and Vanneste, 2012 ; Shekhawat et al, 2015b ).…”

Section: Clinical Approaches For Auditory Related Disordersmentioning

confidence: 99%

Modulating Human Auditory Processing by Transcranial Electrical Stimulation

Heimrath

Fiene

Rufener

et al. 2016

Front. Cell. Neurosci.

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Transcranial electrical stimulation (tES) has become a valuable research tool for the investigation of neurophysiological processes underlying human action and cognition. In recent years, striking evidence for the neuromodulatory effects of transcranial direct current stimulation, transcranial alternating current stimulation, and transcranial random noise stimulation has emerged. While the wealth of knowledge has been gained about tES in the motor domain and, to a lesser extent, about its ability to modulate human cognition, surprisingly little is known about its impact on perceptual processing, particularly in the auditory domain. Moreover, while only a few studies systematically investigated the impact of auditory tES, it has already been applied in a large number of clinical trials, leading to a remarkable imbalance between basic and clinical research on auditory tES. Here, we review the state of the art of tES application in the auditory domain focussing on the impact of neuromodulation on acoustic perception and its potential for clinical application in the treatment of auditory related disorders.

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Section: Clinical Approaches For Auditory Related Disordersmentioning

confidence: 99%

Modulating Human Auditory Processing by Transcranial Electrical Stimulation

Heimrath

Fiene

Rufener

et al. 2016

Front. Cell. Neurosci.

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“…Moreover, tDCS may strengthen task-related dynamic synaptic connections [4]. This technique is widely used to modulate brain activity in clinical scenarios such as stroke rehabilitation [5], pain [6], depression [7] and tinnitus [8]. In healthy subjects, tDCS has shown to modulate pain threshold [9], pain perception and empathy [10].…”

Section: Introductionmentioning

confidence: 99%

Neural signature of tDCS, tPCS and their combination: Comparing the effects on neural plasticity

Thibaut

Russo

Morales-Quezada

et al. 2017

Neuroscience Letters

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Transcranial pulsed current stimulation (tPCS) and transcranial direct current stimulation (tDCS) are two noninvasive neuromodulatory brain stimulation techniques whose effects on human brain and behavior have been studied individually. In the present study we aimed to quantify the effects of tDCS and tPCS, individually and in combination, on cortical activity, sensitivity and pain-related assessments in healthy individuals in order to understand their neurophysiological mechanisms and potential applications in clinical populations. A total of 48 healthy individuals participated in this randomized double blind sham controlled study. Participants were randomized to receive a single stimulation session of either: active or sham tPCS and active or sham tDCS. Quantitative electroencephalography (qEEG), sensitivity and pain assessments were used before and after each stimulation session. We observed that tPCS had a higher effect on power, as compared to tDCS, in several bandwidths on various cortical regions: the theta band in the parietal region (p = 0.021), the alpha band in the temporal (p = 0.009), parietal (p = 0.0063), and occipital (p < 0.0001) regions. We found that the combination of tPCS and tDCS significantly decreased power in the low beta bandwidth of the frontal (p = 0.0006), central (p = 0.0001), and occipital (p = 0.0003) regions, when compared to sham stimulation. Additionally, tDCS significantly increased power in high beta over the temporal (p = 0.0015) and parietal (p = 0.0007) regions, as compared to sham. We found no effect on sensitivity or pain-related assessments. We concluded that tPCS and tDCS have different neurophysiological mechanisms, elicit distinct signatures, and that the combination of the two leads to no effect or a decrease on qEEG power. Further studies are required to examine the effects of these techniques on clinical populations in which EEG signatures have been found altered.

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“…However, there is some doubt as to how long-lasting these effects may be. A recent review of the tDCS literature concluded that most of the studies reviewed reported a temporary reduction in tinnitus loudness or annoyance (14/15), regardless of the exact stimulation parameters and/or location, but none showed any long-term benefit of tDCS [12]. …”

Section: Introductionmentioning

confidence: 99%

The Effects of Compensatory Auditory Stimulation and High-Definition Transcranial Direct Current Stimulation (HD-tDCS) on Tinnitus Perception – A Randomized Pilot Study

et al. 2016

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BackgroundTinnitus correlates with elevated hearing thresholds and reduced cochlear compression. We hypothesized that reduced peripheral input leads to elevated neuronal gain resulting in the perception of a phantom sound.ObjectiveThe purpose of this pilot study was to test whether compensating for this peripheral deficit could reduce the tinnitus percept acutely using customized auditory stimulation. To further enhance the effects of auditory stimulation, this intervention was paired with high-definition transcranial direct current stimulation (HD-tDCS).MethodsA randomized sham-controlled, single blind study was conducted in a clinical setting on adult participants with chronic tinnitus (n = 14). Compensatory auditory stimulation (CAS) and HD-tDCS were administered either individually or in combination in order to access the effects of both interventions on tinnitus perception. CAS consisted of sound exposure typical to daily living (20-minute sound-track of a TV show), which was adapted with compressive gain to compensate for deficits in each subject's individual audiograms. Minimum masking levels and the visual analog scale were used to assess the strength of the tinnitus percept immediately before and after the treatment intervention.ResultsCAS reduced minimum masking levels, and visual analog scale trended towards improvement. Effects of HD-tDCS could not be resolved with the current sample size.ConclusionsThe results of this pilot study suggest that providing tailored auditory stimulation with frequency-specific gain and compression may alleviate tinnitus in a clinical population. Further experimentation with longer interventions is warranted in order to optimize effect sizes.

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Modulation of Perception or Emotion? A Scoping Review of Tinnitus Neuromodulation Using Transcranial Direct Current Stimulation

Cited by 31 publications

References 67 publications

Modulating Human Auditory Processing by Transcranial Electrical Stimulation

Modulating Human Auditory Processing by Transcranial Electrical Stimulation

Neural signature of tDCS, tPCS and their combination: Comparing the effects on neural plasticity

The Effects of Compensatory Auditory Stimulation and High-Definition Transcranial Direct Current Stimulation (HD-tDCS) on Tinnitus Perception – A Randomized Pilot Study

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