Modulation of Oxidative Stress: Pharmaceutical and Pharmacological Aspects

Korkina, Liudmila; Özben, Tomris; Saso, Luciano

doi:10.1155/2016/6023417

Cited by 4 publications

(3 citation statements)

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“… 42 Antibiotics, ultraviolet radiation, alterations in temperature or pH, chemical/diet inducers, and oxidative/inflammatory stressors are all effective factors that promote excision of the phage genome, leading to a switch to a lytic life cycle ( Figure 2 c). 43 , 44 , 45 , 46 In general, prophage induction is phage-dependent and inducer-dependent, whereas many phages do not have such a life cycle. 47 In addition, some phages can lead a pseudolysogenic life cycle under unfavourable environmental conditions, where the phage genome exists in the bacterial cell as a plasmid-like (episomal) construct without integration or replication.…”

Section: The Function Of the Gut Viromementioning

confidence: 99%

The gut virome: A new microbiome component in health and disease

et al. 2022

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Section: The Function Of the Gut Viromementioning

confidence: 99%

The gut virome: A new microbiome component in health and disease

et al. 2022

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“…The phenotypic expression of MDR is the frustrating outcome of an initially successful chemotherapy treatment that affects and seriously compromises the effectiveness of conventional drugs, thus determining a consequent poor prognosis (54). Those responsible for drug resistance are the ATP-binding cassette transporters (ABCs), which pump a variety of drugs out of cells at the expense of ATP hydrolysis.…”

Section: Effectiveness Of Feijoa Against Multidrugresistant Cancer Ce...mentioning

confidence: 99%

Feijoa Sellowiana fruit, an amazing source of anticancer molecules

Cimmino¹,

Cianciullo²,

Maresca³

et al. 2022

Ann Res Oncol

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Feijoa sellowiana O. Berg is a tropical plant with edible fruits and characterised by a high content of flavonoids. Several studies have shown that Feijoa contains many bioactive components such as flavonoids, vitamin C, and essential minerals that contribute to multiple health benefits, such as antimicrobial, anti-inflammatory, antioxidant, and anticancer activities. Regarding anticancer activity, several authors have shown that the Feijoa fruit acetonic extract and the molecules isolated by it have a selective cytotoxic effect, induce apoptosis, modulate cell cycle against solid and hematologic tumours and are effective against sensitive and resistant cancer cells. This review summarizes Feijoa fruit biological activities that have so far been identified with a focus on anticancer activity.

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“…For example, increased levels of NADPH oxidase after TBI damages mitochondria and other organelles ( Bordt and Polster, 2014 ; Angeloni et al, 2015 ; Ma et al, 2017 ). Pharmacological inhibitors of free radicals such as NOX, peroxides, peroxynitrites/nitrates, hypochlorites, phenols and prostanoid antagonists can modulate free radical production and suppress inflammation ( Cheng et al, 2012 ; Korkina et al, 2016 ; Ma et al, 2017 ; Smith et al, 2019 ). Studies have shown that inhibition or genetic ablation of NADPH oxidase improves outcomes in terms of neurodegeneration, oxidative stress mediated mitochondrial dysfunction, gliosis, and increases neurogenesis ( Cheng et al, 2012 ; Altenhöfer et al, 2015 ; Hirano et al, 2015 ; Maqbool et al, 2020 ).…”

Section: Therapeutic Intervention and Managementmentioning

confidence: 99%

Neuropathophysiological Mechanisms and Treatment Strategies for Post-traumatic Epilepsy

Sharma

Tiarks

Haight

et al. 2021

Front. Mol. Neurosci.

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Traumatic brain injury (TBI) is a leading cause of death in young adults and a risk factor for acquired epilepsy. Severe TBI, after a period of time, causes numerous neuropsychiatric and neurodegenerative problems with varying comorbidities; and brain homeostasis may never be restored. As a consequence of disrupted equilibrium, neuropathological changes such as circuit remodeling, reorganization of neural networks, changes in structural and functional plasticity, predisposition to synchronized activity, and post-translational modification of synaptic proteins may begin to dominate the brain. These pathological changes, over the course of time, contribute to conditions like Alzheimer disease, dementia, anxiety disorders, and post-traumatic epilepsy (PTE). PTE is one of the most common, devastating complications of TBI; and of those affected by a severe TBI, more than 50% develop PTE. The etiopathology and mechanisms of PTE are either unknown or poorly understood, which makes treatment challenging. Although anti-epileptic drugs (AEDs) are used as preventive strategies to manage TBI, control acute seizures and prevent development of PTE, their efficacy in PTE remains controversial. In this review, we discuss novel mechanisms and risk factors underlying PTE. We also discuss dysfunctions of neurovascular unit, cell-specific neuroinflammatory mediators and immune response factors that are vital for epileptogenesis after TBI. Finally, we describe current and novel treatments and management strategies for preventing PTE.

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Modulation of Oxidative Stress: Pharmaceutical and Pharmacological Aspects

Cited by 4 publications

References 0 publications

The gut virome: A new microbiome component in health and disease

The gut virome: A new microbiome component in health and disease

Feijoa Sellowiana fruit, an amazing source of anticancer molecules

Neuropathophysiological Mechanisms and Treatment Strategies for Post-traumatic Epilepsy

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