Modulation of nitric oxide improves cyclosporin A-induced hypertension in rats and primates

Bartholomeusz, Briony; Hardy, Kenneth J.; Nelson, Anitra; Phillips, P A

doi:10.1038/sj.jhh.1000709

Cited by 27 publications

(14 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These agents may increase systemic vascular resistance and cause renal vasoconstriction through several mechanisms, including activation of vasoconstrictor factors, such as renin–angiotensin system, endothelin, and thromboxane A2, while reducing the production of vasodilator compounds, such as nitric oxide and prostacyclin [6–10]. Cyclosporin, but not tacrolimus, can also cause an early rise in sympathetic tone that may contribute to the acute elevation of blood pressure.…”

Section: Pathogenesis Of Post‐transplant Hypertensionmentioning

confidence: 99%

Hypertension in kidney transplant recipients

Ponticelli

Cucchiari

Graziani

2011

Transplant International

View full text Add to dashboard Cite

Summary Arterial hypertension is frequently observed in renal transplant recipients. Its pathogenesis is multifactorial in most cases. Calcineurin inhibitors (CNI) can increase peripheral vascular resistance by inducing arteriolar vasoconstriction and can cause extracellular fluid expansion by reducing the glomerular filtration rate (GFR), activating the renin–angiotensin system (RAS), and by inactivating the atrial natriuretic peptide. Glucocorticoids can impair urinary water and salt excretion. Poor graft function can lead to increased extracellular volume and inappropriate production of renin. Native kidneys, older age of the donor and transplant renal artery stenosis (TRAS) may also contribute to the development of hypertension. Arterial hypertension not only can increases the risk for cardiovascular events but can also deteriorate renal allograft function. A number of studies have shown that the higher the levels of blood pressure are, the higher is the risk of graft failure. On the other hand, a good control of blood pressure may prevent many cardiovascular and renal complications. Appropriate lifestyle modification is the first step for treating hypertension. Calcium channel blockers (CCB) and renin–angiotensin system (RAS) inhibitors are the most frequently used antihypertensive agents, but in many cases, a combination of these and other drugs is required to obtain good control of hypertension.

show abstract

Section: Pathogenesis Of Post‐transplant Hypertensionmentioning

confidence: 99%

Hypertension in kidney transplant recipients

Ponticelli

Cucchiari

Graziani

2011

Transplant International

View full text Add to dashboard Cite

show abstract

Section: Reduced Endothelin-1-and Nitric Oxide-mediated Arteriolar Tomentioning

confidence: 99%

“…Several lines of evidence suggest that ET-1 plays a pivotal role in post-transplant hypertension [4][5][6]. In addition, it was reported that calcineurin inhibitors may interfere with nitric oxide (NO)-mediated vascular relaxation [7][8][9].We were therefore interested in the question if increased vascular ET-1 and/or reduced nitric oxide could be shown to participate in post-transplant hypertensionassociated vascular dysfunction in patients. We tested the functional state of the vascular endothelin and NO system in vivo in renal allograft recipients with hypertension and matched healthy control subjects.…”

mentioning

confidence: 99%

Reduced endothelin-1– and nitric oxide–mediated arteriolar tone in hypertensive renal transplant recipients

Passauer

Lässig

Büssemaker

et al. 2004

Kidney International

View full text Add to dashboard Cite

show abstract

“…Among the mechanisms leading to these side effects, various alterations in NO signalling pathway have been identified as key determinants for the development of renal and coronary vasculopathies [7,16,17]. The inhibition by CsA of the activity of a specific NO synthase (NOS) isoform, e.g., endothelial NOS (eNOS), was identified as a major trigger leading to vasodilatation impairments.…”

Section: Introductionmentioning

confidence: 99%