Modulation of NGF by cortisol and the Stellate Ganglion Block – Is this the missing link between memory consolidation and PTSD?

Regulating autonomic nervous system homeostasis improves pulmonary function in rabbits with acute lung injury

“…Our study showed that SGB can regulate ANS balance by inhibiting excessive SNS activity and effectively alleviate nociceptive responses, which is consistent with previous description [3, 13]. In addition, rabbits in the SGB group achieved the most improvement from HCl aspiration in our study, with no obvious effects on HR and MAP throughout the experiment.…”

Stellate Ganglion Block in the Treatment of Post‐traumatic Stress Disorder: A Review of Historical and Recent Literature

“…The secondary literature search identified an additional 7 publications resulting in 32 publications included in the review. These comprised 15 case reports and case series, 1 systematic case review, 2 publications related to a single published RCT, and 14 nonsystematic reviews, opinions, guidelines, commentaries, books, and book chapters . The systematic search results are shown in Figure .…”

“…Despite some disagreement in the literature related to the postulated beneficial neurophysiological mechanism of the procedure, in 2012 and 2013, 3 case series and a case report totaling 22 patients—many of which were current or former military service members—added further evidence to the literature of clinical efficacy of SGB for treatment of PTSD, including occasionally marked reductions in standard PTSD symptom scores . Multiple supporting publications authored by a core group of investigators during the period expanded on the proposed beneficial mechanism, and additional reviews added to the evidence of beneficial results from the use of SGB for treatment of PTSD . In 2014, Navaie et al .…”

“…These comprised 15 case reports and case series, 12,20,22-34 1 systematic case review, 35 2 publications related to a single published RCT, 36,37 and 14 nonsystematic reviews, opinions, guidelines, commentaries, books, and book chapters. 21,[38][39][40][41][42][43][44][45][46][47][48][49][50] The systematic search results are shown in Figure 1. One case report which included an analysis described as a systematic review was considered a case report for these purposes.…”

“…The physiological mechanism or mechanisms responsible for the observed psychiatric benefits of SGB for PTSD have not been confirmed, although previously proposed mechanisms have been built upon to inform current plausible hypotheses …”