Modulation of neutrophil apoptosis by plasma and peritoneal fluid from patients with advanced endometriosis

Kwak, Jong‐Young; Park, Sang-Won; Kim, Ki-Hyung; Na, Yong-Jin; Lee, Kyusup

doi:10.1093/humrep/17.3.595

Cited by 46 publications

(33 citation statements)

References 37 publications

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“…Role neutrophil in infected endometrioma was not only eliminate bacteria but also proving endometriosis cell to grow. In this study neutrophil level was increasing 77.05+15.15 compared in endometriosis only 67.75+9.37.One study reveled level of the neutrophil in endometriosis was 4.14+1.73 103/uL) and this correspond to this study [12,13,14,16].…”

Section: Discussionsupporting

confidence: 82%

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Expression of CA-125 Level And Neutrophil to Lymphocyte Ratio In Infected And Non-infected Endometrioma

Surya¹,

Harzif²,

Maidarti³

et al. 2017

Kme

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Section: Discussionsupporting

confidence: 82%

“…However, there were no study measuring CA-125 in infected endometrioma. Therefore, measuring mean in leucocyte, NLR, PLR and CA-125 level in infected endometrioma was necessary [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Expression of CA-125 Level And Neutrophil to Lymphocyte Ratio In Infected And Non-infected Endometrioma

Surya¹,

Harzif²,

Maidarti³

et al. 2017

Kme

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“…Could C. trachomatis infection limit the extent and severity of endometriosis or, conversely, does a pre-existing endometriosis condition limit C. trachomatis infection? It may be possible that tubal occlusion resulting from C. trachomatis infection may create a physical barrier against endometrial tissue passing through the fallopian tube or, alternatively, immune responses generated during endometriosis such as elevated cytokine expression 2,32,33 , increased neutrophil activity [34][35][36] and increased phagocytic activity 37,38 may clear chlamydial colonisation before the development of florid infection.…”

Section: Discussionmentioning

confidence: 99%

Interaction of Microbiology and Pathology in Women Undergoing Investigations for Infertility

Debattista

Gazzard²,

Wood³

et al. 2000

Infectious Diseases in Obstetrics and Gynecology

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Background: Cases of endometriosis with no tubal damage are associated with infertility, suggesting an immunological rather than mechanical barrier to reproduction. Laparoscopy and falloposcopy results of clinically asymptomatic women undergoing investigation of infertility were correlated with the outcomes of microbiological screening for Chlamydia trachomatis, Mycoplasma pneumoniae, Mycoplasma hominis, ureaplasma species, Neisseria gonorrhoeae, Neisseria meningitidis and Chlamydia pneumoniae. Methods: A total of 44 women presenting to a hospital IVF service for laparoscopic or laparoscopic/ falloposcopic investigation of infertility provided endocervical swabs, fallopian tube washings, and peripheral whole blood for analysis. Results: Of these 44 women, 15.9% (7) showed evidence of C. trachomatis infection as detected by either PCR or EIA serology. Of these 7 women, 5 (71%) had no or mild endometriosis and 2 (29%) had moderate or severe endometriosis. Of the remaining 37 women who showed no evidence of chlamydial infection, 15 (40.5%) had no or mild endometriosis. Conclusion: Women with infertility, but without severe endometriosis at laparoscopy, showed a trend towards tubal damage and a higher rate of previous C. trachomatis infection. Although not statistically significant, this trend would suggest that, where moderate to severe tubal damage is found to be the primary cause of infertility, C. trachomatis infection could be a likely cause for such tubal damage.

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“…Neutrophils were isolated from total blood in a dextran solution following a previously reported protocol (30). Purity of all cultures was verified by CD16b staining; on average, we obtained 88% of CD16b-positive cells.…”

Section: Human Neutrophils Isolation and Culturementioning

confidence: 99%

Metalloproteinases Shed TREM-1 Ectodomain from Lipopolysaccharide-Stimulated Human Monocytes

Gómez-Piña

Soares‐Schanoski

Rodríguez‐Rojas

et al. 2007

The Journal of Immunology

174

155

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Triggering receptors expressed on myeloid cell (TREM) proteins are a family of cell surface receptors that participate in diverse cellular processes such as inflammation, coagulation, and bone homeostasis. TREM-1, in particular, is expressed on neutrophils and monocytes and is a potent amplifier of inflammatory responses. LPS and other microbial products induce up-regulation of cell surface-localized TREM-1 and the release of its soluble form, sTREM-1. Two hypotheses have been advanced to explain the origin of sTREM-1: alternative splicing of TREM-1 mRNA and proteolytic cleavage(s) of mature, membrane-anchored TREM-1. In this report, we present conclusive evidence in favor of the proteolytic mechanism of sTREM-1 generation. No alternative splicing forms of TREM-1 were detected in monocytes/macrophages. Besides, metalloproteinase inhibitors increased the stability of TREM-1 at the cell surface while significantly reducing sTREM-1 release in cultures of LPS-challenged human monocytes and neutrophils. We conclude that metalloproteinases are responsible for shedding of the TREM-1 ectodomain through proteolytic cleavage of its long juxtamembrane linker.

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Modulation of neutrophil apoptosis by plasma and peritoneal fluid from patients with advanced endometriosis

Abstract: These findings show that interleukin-8 is one of the neutrophil survival factors in the peritoneal fluid of endometriosis patients and that an unidentified survival factor is also present in the plasma of patients with endometriosis.

Cited by 46 publications

References 37 publications

Expression of CA-125 Level And Neutrophil to Lymphocyte Ratio In Infected And Non-infected Endometrioma

Expression of CA-125 Level And Neutrophil to Lymphocyte Ratio In Infected And Non-infected Endometrioma

Interaction of Microbiology and Pathology in Women Undergoing Investigations for Infertility

Metalloproteinases Shed TREM-1 Ectodomain from Lipopolysaccharide-Stimulated Human Monocytes

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