2012
DOI: 10.1016/j.ygcen.2011.11.011
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Modulation of neuroplastic changes and corticotropin-releasing factor-associated behavior by a phylogenetically ancient and conserved peptide family

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Cited by 16 publications
(18 citation statements)
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“…One possibility is that this 41-mer does not exist in vivo, but rather represents the functional region of the 15 kDa form. However, the uptake of FITC-labeled TCAP-1, an R/K-Xn-R/K prohormone convertase cleavage motif (Seidah and Chretien, 1999) adjacent to the mature peptide and bioactivity of synthetic TCAP-1 both in vitro and in vivo (Tan et al, 2011b), suggests that cleavage of the 13-15 kDa pro-peptide could occur to liberate TCAP-1. TCAP-1 may, therefore, be translated or released as the 13-15 kDa form, but cleaved in the extracellular region immediately before binding and uptake by surrounding cells.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…One possibility is that this 41-mer does not exist in vivo, but rather represents the functional region of the 15 kDa form. However, the uptake of FITC-labeled TCAP-1, an R/K-Xn-R/K prohormone convertase cleavage motif (Seidah and Chretien, 1999) adjacent to the mature peptide and bioactivity of synthetic TCAP-1 both in vitro and in vivo (Tan et al, 2011b), suggests that cleavage of the 13-15 kDa pro-peptide could occur to liberate TCAP-1. TCAP-1 may, therefore, be translated or released as the 13-15 kDa form, but cleaved in the extracellular region immediately before binding and uptake by surrounding cells.…”
Section: Discussionmentioning
confidence: 99%
“…Recent evidence indicates that the TCAP-1 region of the teneurin-1 may act as a novel neuroplastic regulatory factor in the rodent brain (Tan et al, 2011b). In vitro, TCAP-1 increases cytoskeletal proteins including β-actin and β-tubulin, modulates neurite outgrowth in cultured hippocampal neurons (Al Chawaf et al, 2007a) and inhibits brain derived neurotrophic factor (BDNF) expression in hypothalamic cells (Ng et al, 2012).…”
Section: Introductionmentioning
confidence: 99%
“…Application of the Teneurin-2 C-terminus in hippocampal culture induces presynaptic Ca 2+ signaling (Silva et al, 2011 ). This is reminiscent of the Teneurin C-terminal associated peptide (TCAP), a 41-residue peptide that can be liberated and is thought to regulate stress response, dendritic remodeling in the hippocampus, BDNF levels, and corticotropin-releasing factor signaling (Rotzinger et al, 2010 ; Ng et al, 2012 ; Tan et al, 2012 ; Chen et al, 2013 ). Indeed, Teneurin-2 can be cleaved in culture (Silva et al, 2011 ), supporting this model but could also function by another, unknown mechanism.…”
Section: Synaptic Teneurins In Vertebrate Systemsmentioning
confidence: 99%
“…Since then, four TCAPs have been identified in vertebrates, annotated as TCAP-1,-2, -3, and -4, based on their location in the four teneurin genes. All TCAPs are the same size as CRF, but possess less than 20% sequence similarity to the CRF family of peptides (Lovejoy et al, 2006 ) and differ markedly in structure (Tan et al, 2012 ). However, the TCAP family is highly conserved across the metazoans.…”
Section: Discovery and Structure Of Teneurins Tcap And Latrophilinsmentioning
confidence: 99%