Modulation of neural response to happy and sad faces by acute tryptophan depletion

Fusar‐Poli, Paolo; Allen, Paul; Lee, Francis; Surguladze, Simon; Tunstall, Nigel; Fu, Cynthia H.Y.; Brammer, Michael; Cleare, Anthony J.; McGuire, Philip

doi:10.1007/s00213-007-0757-4

Cited by 37 publications

(36 citation statements)

References 90 publications

(109 reference statements)

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“…Although a handful of studies have indicated that TRP-does alter brain activity and performance in PH-/FH-individuals during facial expression processing [60,62] , results are inconsistent. Additionally, behavioral and neuroimaging differences have been noted with TRP-on emotive facial processing between PH-and PH+ individuals [85] , consistent with indirect evidence suggesting that TRP-may alter brain activity differently in PH+/FH+ and PH-/FHgroups [86][87][88][89] .…”

Section: Limitations and Future Directionsmentioning

confidence: 84%

“…One study found that TRP-increased negative facial expression processing in FH+ females [59] , while another found that it decreased fear but increased disgust recognition in remitted depressives [60] . Several studies in PH-/FH-individuals did not find altered performance on facial recognition tasks with TRP- [61,62] , although one found that it impaired fear recognition in healthy females [46] . Previous work in our laboratory indicated that TRP-enhanced early visual ERPs (P100, P200) to sad versus happy faces in FH+ individuals [16] .…”

Section: Serotonin and Facial Processingmentioning

confidence: 99%

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Acute Tryptophan Depletion Effects on the Vertex and Late Positive Potentials to Emotional Faces in Individuals with a Family History of Depression

Jaworska¹,

Thompson²,

Shah³

et al. 2011

Neuropsychobiology

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Background: Depression, which is associated with dysfunctional serotonin (5-HT) activity, may be characterized by impaired emotional information processing. This study assessed the effects of acute tryptophan depletion (TRP–), which transiently lowers CNS 5-HT, on the emotion-sensitive vertex positive potential (VPP) and late positive potential (LPP) event-related potentials (ERPs) and mood in individuals with a family history of depression. The VPP and LPP are thought to index the early and later stages of motivated attentional processing, respectively. Method: Within a double-blind balanced design, ERPs were acquired in 18 individuals with a family history of depression (12 females) after TRP– and TRP+ (balanced) treatment while participants were presented with facial expressions (neutral, as well as sad, joy and surprise at 50 and 100% intensity) and responded to surprised faces. Results: TRP– increased total mood disturbance and maintained depression scores. The VPP and LPP were larger to intense versus mild expressions. Enhanced processing of emotional versus neutral faces, as indexed by the VPP, was primarily evident with TRP–. Speeded and enhanced processing of intensely joyful versus mildly sad faces was found with TRP– (VPP indexed). Compared with TRP+, TRP also increased the VPP to mildly joyful faces. Conclusion: Transient 5-HT decreases in individuals with a family history of depression induce subtle changes in early stages of motivated emotional processing, though not in later ones.

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Section: Limitations and Future Directionsmentioning

confidence: 84%

Section: Serotonin and Facial Processingmentioning

confidence: 99%

Acute Tryptophan Depletion Effects on the Vertex and Late Positive Potentials to Emotional Faces in Individuals with a Family History of Depression

Jaworska¹,

Thompson²,

Shah³

et al. 2011

Neuropsychobiology

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“…Studies applying ATD in healthy subjects during fMRI revealed increased activity in frontal brain regions in response to emotional faces (Fusar-Poli et al 2007;Daly et al 2010) as well as during a Stroop task (Horacek et al 2005), whereas two studies using Go/Nogo paradigms showed decreased activity in frontal regions (Rubia et al 2005;Evers et al 2006). Cingulate activity was increased in one study (Fusar-Poli et al 2007) using emotional faces, but decreased in the other (Daly et al 2010), whereas insular activity was modulated in the opposite direction during emotional faces (decrease in Fusar-Poli et al 2007, increase in Daly et al 2010). Occipital cortical activity was decreased in both studies using emotional faces (Fusar-Poli et al 2007;Daly et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Differential modulation of emotion processing brain regions by noradrenergic and serotonergic antidepressants

Brühl¹,

Jäncke

Herwig

2011

Psychopharmacology

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The brain regions involved in the processing of negative emotional stimuli were differentially modulated by selective noradrenergic and serotonergic drugs: thalamic activity was increased by reboxetine, whereas citalopram primarily affected ventrolateral prefrontal regions. Thus, dysfunction in these regions, which could be identified in depressed patients, may predict treatment responses to either noradrenergic or serotonergic antidepressants.

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“…The insula cortex, which forms part of a so-called 'paralimbic' circuit is known to be important for the representation and monitoring of emotional states (Critchley et al, 2004), the superior temporal gyrus has been associated with the processing of both facial and other social stimuli (Habel et al, 2005;Ashwin et al, 2007;Barraclough et al, 2005) and the inferior frontal gyrus is important in impulsive behavior, which may be impaired in patients with depression. Indeed functionality within these regions is sensitive to serotonergic manipulations with SSRI administration (Smith et al, 2002;Anderson et al, 2007;Arce et al, 2008;Nemoto et al, 2003), and tryptophan depletion (Fusar-poli et al, 2007;Rubia et al, 2005). Although it is known that sub-populations of 5-HT neurons are present in the midbrain, their differential anatomical connectivity is not known.…”

Section: Discussionmentioning

confidence: 99%

Presynaptic 5-HT1A is Related to 5-HTT Receptor Density in the Human Brain

Bose¹,

Mehta²,

Selvaraj³

et al. 2011

Neuropsychopharmacol

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5-Hydroxytryptamine (5-HT or serotonin) is an important neurotransmitter for a number of brain functions and widely distributed throughout the brain. Physiological and pharmacological relationship between 5-HT1A receptors and serotonin transporter (5-HTT) in the regulation of 5-HT neurotransmission has now been documented. A relationship between 5-HT1A receptors and 5-HTT is also suggested by the pathophysiology of depression and the mechanism of action of antidepressants. We have scanned 42 healthy adults with both [11C] WAY-100635 and [11C] DASB to investigate the anatomical co-distribution of multiple serotonergic markers. We hypothesized that lower 5-HTT densities in the dorsal raphe nucleus (DRN) and limbic regions will be accompanied by lower 5-HT1A receptor density in the same regions, contributing to the 5-HT1A receptor desensitization. In addition, variations in DRN 5-HT1A receptor density can theoretically influence the density and/or function of other serotonin receptor subtypes and the 5-HTT consequent to changes in serotonergic tone. In a comparatively large sample of volunteers, we have shown that the relationship between 5-HT1A and 5-HTT PET indices was complex. We were unable to demonstrate robust, intra-regional relationships between 5-HT1A and 5-HTT densities. Inter-regionally, DRN 5-HT1A receptors were related to cortical (temporal and frontal regions) and paralimbic (insula), but not limbic 5-HTT. This latter finding may reflect differences in 5-HT tone between individuals, and highlights probable substrates sensitive to variations in DRN 5-HT function.

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Modulation of neural response to happy and sad faces by acute tryptophan depletion

Abstract: In both cortical and sub-cortical regions, the neural response associated with processing emotional faces is significantly modulated by 5HT manipulation resulting from ATD. Moreover, in certain areas, this effect of 5HT depends on the emotional valence of the stimulus.

Cited by 37 publications

References 90 publications

Acute Tryptophan Depletion Effects on the Vertex and Late Positive Potentials to Emotional Faces in Individuals with a Family History of Depression

Acute Tryptophan Depletion Effects on the Vertex and Late Positive Potentials to Emotional Faces in Individuals with a Family History of Depression

Differential modulation of emotion processing brain regions by noradrenergic and serotonergic antidepressants

Presynaptic 5-HT1A is Related to 5-HTT Receptor Density in the Human Brain

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