Modulation of Mitoxantrone Cytotoxicity by Verapamil in Human Chronic Myeloid Leukemia Cells

Satyamoorthy, Kapaettu; Chitnis, M.P.; Pradhan, S.G.; Advani, Suresh H.

doi:10.1159/000226699

Cited by 11 publications

(2 citation statements)

References 17 publications

(24 reference statements)

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“…22]. Various compounds which are clinically utilised in ailments other than cancer, such as verapamil [7,10,23], trifluoperazine [11], nitroxazepine [24] and chloimipramine [25] have been shown to potentiate the activity of Adr in both drug-sensitive and drug-resistant cells. Tween 80 has also been shown to enhance the efficacy of various antitumor agents in vitro and in vivo, in experimental tumor models [14,15], Kerr et al [16] have recently reported that B-30 enhances the cellular uptake of Adr and improves the cytotoxicity of Adr in monolayer, clonogenic and spheroid culture systems.…”

Section: Effect O F B-30 and B-35 On A Dr Cytotoxicity In S I80 And Ementioning

confidence: 99%

Effect of Alterations in Permeability by Nonionic Surfactants on Adriamycin Cytotoxicity in Murine Tumor Models in vitro

Parekh¹,

Chitnis²

1990

Oncology

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Differential effects of adriamycin cytotoxicity and its cellular uptake were assessed in murine tumor models utilising adriamycin alone and in combination with nontoxic concentrations of nonionic polyoxyethylated lauryl ether surfactants Brij 30 and Brij 35. Parental P388 murine leukemia cell line sensitive to adriamycin, subline of P388 murine leukemia resistant to adriamycin, sarcoma-180 and Ehrlich ascites tumor were employed in this study. The results indicate an enhanced DNA biosynthesis inhibition by adriamycin when used in combination with Brij 30 or Brij 35 in all the murine tumor models. The increase in adriamycin cytotoxicity was due to an increased accumulation of adriamycin observed in the tumor models used. The present investigation demonstrates the necessity of utilising surface-active drug-response modulators to enhance the cytotoxicity of anticancer drugs and circumvent drug resistance.

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Section: Effect O F B-30 and B-35 On A Dr Cytotoxicity In S I80 And Ementioning

confidence: 99%

Effect of Alterations in Permeability by Nonionic Surfactants on Adriamycin Cytotoxicity in Murine Tumor Models in vitro

Parekh¹,

Chitnis²

1990

Oncology

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“…Anthraquinone compounds, especially daunoribicin, doxorubicin, epirubicin and mitoxantrone, are the most effective clinical anticancer medications (21). Mitoxantrone, with its planar anthraquinone structure, is a clinically useful antineoplastic agent (22)(23)(24)(25)(26)(27)(28) SZ-685C, one of sea anthraquinone metabolites, represses human breast cancer and human nasopharyngeal carcinoma cells (29). Anthraquinones have high antitumor effect.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Acetyl- and Butyrylcholinesterase Enzyme Inhibitory Activities and Cytotoxic Activities of Anthraquinone Derivatives

OZKOK

Boğa

TUNEG

et al. 2022

Journal of the Turkish Chemical Society Section A: Chemistry

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In this study, the enzyme activity of anthraquinone compounds which were synthesized beforehand by our research group was investigated. Molecular docking studies were performed for compounds 1-(4-aminophenylthio)anthracene-9,10-dione (3) and 1-(4-chlorophenylthio)anthracene-9,10-dione (5). Compound 3 was synthesized from the reaction of 1-chloroanthraquinone (1) and 4aminothiophenol (2). Compound 5 was synthesized (1) from the reaction of 1-chloroanthraquinone (1) and 4-chlorothiophenol (4). Anthraquinone analogs (3, 5) were synthesized with a new reaction method made by our research group (2). Inhibitory effects of compounds 3 and 5 were investigated against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes which are related to Alzheimer's Disease (AD). Compounds 3 and 5 exhibited strong anti-acetyl-and butyryl-cholinesterase inhibition activities than galanthamine used as standard compound (92.11±1.08 and 80.95±1.77 %, respectively). The EHOMO-ELUMO values, molecular descriptors, and the calculated UV-Vis spectra of anthraquinone derivatives were computed by B3LYP/6-31+G(d,p) levels in the CHCl3 phase. Based on the fluorescence property of the anthraquinone skeleton, the fluorescence activity of the bioactive anthraquinone analogue (5) was investigated. MTT test was performed to determine the cytotoxic effects of thioanthraquinone molecules 3 and 5. In MTT analyses, 3 compounds showed the highest effect against Ishikawa cells at a dose of 10 µg/mL, while compound 5 showed the highest effect at a dose of 50 µg/mL. The cell viability for compound 3 was 84.18% for 10 µg/mL and the cell viability for compound 5 was 75.02% for 50 µg/mL.

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Pharmacokinetic and pharmacodynamic optimization of intraperitoneal chemotherapy

Balthasar

Fung²

1996

Life Sciences

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Modulation of Mitoxantrone Cytotoxicity by Verapamil in Human Chronic Myeloid Leukemia Cells

Cited by 11 publications

References 17 publications

Effect of Alterations in Permeability by Nonionic Surfactants on Adriamycin Cytotoxicity in Murine Tumor Models in vitro

Effect of Alterations in Permeability by Nonionic Surfactants on Adriamycin Cytotoxicity in Murine Tumor Models in vitro

Evaluation of Acetyl- and Butyrylcholinesterase Enzyme Inhibitory Activities and Cytotoxic Activities of Anthraquinone Derivatives

Pharmacokinetic and pharmacodynamic optimization of intraperitoneal chemotherapy

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