Modulation of memory processing by neuropeptide Y

The Neuropeptide Y (NPY) Y1 Receptor Subtype Mediates NPY-induced Antidepressant-like Activity in the Mouse Forced Swimming Test

“…Intracerebroventricular (ICV) administration of NPY stimulates food intake (Clark et al 1985;Levine and Morley 1984;Stanley and Leibowitz 1984), modulates cognition (Flood et al 1987;Redrobe et al 1999), inhibits neuronal excitability (Colmers and Bleakman 1994) and has anticonvulsant effects (Vezzani et al 1999). NPY modulates the secretion of various hypothalamic neuropeptides, stimulates the corticotrophic axis (Krysiak et al 1999;Small et al 1997) and has potent inhibitory effects on gonadotrophic and somatotrophic axes (Catzeflis et al 1993).…”

Novel analogues of neuropeptide Y with a preference for the Y1‐receptor

“…Profound effects on stimulation of food intake, secretion of luteinizing and growth hormone, and insulin release suggest an important role for NPY in the pathophysiology of obesity and diabetes [2±5]. A wide range of other effects of NPY have been reported, such as potent vasoconstriction [6], facilitation of learning and memory [7], modulation of locomotor behaviours [8], induction of hypothermia [9,10], inhibition of sexual behaviour [11], shifts in circadian rhythms [12], modulation of cardiorespiratory parameters[13], anxiolytic potency [14] and inhibition of alcohol consumption and resistance [15].NPY is a 36-amino acid peptide amide belonging to the family of pancreatic polypeptides that includes also pancreatic polypeptide (PP) and peptide YY; it was first isolated from pig brain in 1982 [16].NPY is widely distributed within the central nervous system and in the periphery. [25,26].…”

“…Profound effects on stimulation of food intake, secretion of luteinizing and growth hormone, and insulin release suggest an important role for NPY in the pathophysiology of obesity and diabetes [2±5]. A wide range of other effects of NPY have been reported, such as potent vasoconstriction [6], facilitation of learning and memory [7], modulation of locomotor behaviours [8], induction of hypothermia [9,10], inhibition of sexual behaviour [11], shifts in circadian rhythms [12], modulation of cardiorespiratory parameters…”

Mechanism of dopamine mediated inhibition of neuropeptide Y release from pheochromocytoma cells (PC12 cells)

“…When the results were analyzed by two-way ANOVA they neither statistically stimulated nor inhibited the release of NPY from differentiated PC12 cells over a wide concentration range (10 −7 to 10 −4 M). These results suggest that activation of D 2 receptors, but not D 1 , D 3 or D 4 receptors, are involved in the dopaminergic-induced inhibition of NPY-ir release.…”

“…It is thought to be involved in a variety of physiological functions such as blood pressure regulation [2,3], memory processing and retention (4,5), and its most noticeable effect, that of stimulation of feeding [6,7]. It is a ubiquitous neuropeptide both in the central and peripheral nervous system.…”