Modulation of lymphocyte phenotype and function by immunoglobulins

Kirschbaum, Jerome Ormond; Forschner, K.; Rasche, Claudia; Worm, Margitta

doi:10.1111/j.1365-2133.2005.07005.x

Cited by 5 publications

(3 citation statements)

References 33 publications

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“…However, these models have never adequately accounted for the increase of Treg cells after IVIG treatment in psoriasis, skin transplants [18, 19], and experimental autoimmune encephalomyelitis (EAE) [20]. We propose that Tregitopes may be responsible for IVIG-induced tolerance; this hypothesis is corroborated by published reports that polyclonal immunoglobulin therapies induce expansion of Tregs and IL-10 secretion in vivo in animals and humans [21, 22].…”

Section: Relationship To Igg and Ivigmentioning

confidence: 65%

In Vitro and In Vivo Studies of IgG-derived Treg Epitopes (Tregitopes): A Promising New Tool for Tolerance Induction and Treatment of Autoimmunity

et al. 2012

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Tregitopes are regulatory T cell epitopes derived from immunoglobulin G (IgG) that stimulate CD25+ FoxP3+ T cells to expand. In conjunction with these Tregs, Tregitopes can prevent, treat, and even cure autoimmune disease in mouse models, suppress allo-specific responses in murine transplant models, inhibit CD8+ T cell responses to recombinant adeno-associated virus (AAV) gene transfer vectors, and induce adaptive Tregs in DO11.10 mice. In this review of recent Tregitope studies, we summarize their effects in vitro and describe recent comparisons between intravenous IgG (IVIG) and Tregitopes in standard in vivo immune tolerance models. Further investigations of the mechanism of action of Tregitopes in the preclinical models described here will lead to clinical trials where Tregitopes may have the potential to alter the treatment of autoimmune disease, transplantation, and allergy, and to improve the efficiency of gene and protein replacement therapies.

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Section: Relationship To Igg and Ivigmentioning

confidence: 65%

In Vitro and In Vivo Studies of IgG-derived Treg Epitopes (Tregitopes): A Promising New Tool for Tolerance Induction and Treatment of Autoimmunity

et al. 2012

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“…1). It has been demonstrated that CD23 expression on B cells tends to down-regulate following stimulation with IgG1 immunoglobulins and may also be related to antibody-induced B cell modulation [17]. Moreover, CD32, the major Fc-gR expressed by mature B cells, associated with negative B cell receptor (BCR) signalling [18,19] was found to be up-regulated on B lymphocytes at day 15.…”

Section: Cell Phenotypesmentioning

confidence: 99%

Activation/modulation of adaptive immunity emerges simultaneously after 17DD yellow fever first-time vaccination: is this the key to prevent severe adverse reactions following immunization?

Martins

Silva

Marciano

et al. 2007

Clinical and Experimental Immunology

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SummaryOver past decades the 17DD yellow fever vaccine has proved to be effective in controlling yellow fever and promises to be a vaccine vector for other diseases, but the cellular and molecular mechanisms by which it elicits such broadbased immunity are still unclear. In this study we describe a detailed phenotypic investigation of major and minor peripheral blood lymphocyte subpopulations aimed at characterizing the kinetics of the adaptive immune response following primary 17DD vaccination. Our major finding is a decreased frequency of circulating CD19+ cells at day 7 followed by emerging activation/modulation phenotypic features (CD19 + and CD8 + cells further support this hypothesis. We hypothesize that this controlled microenviroment seems to be the key to prevent the development of serious adverse events, and even deaths, associated with the 17DD vaccine reported in the literature.

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“…The anti-infl ammatory activity of IVIG is attributed to multiple mechanisms including binding of the IgG Fc domain to Fc-gamma receptors, blockade of the FcRn receptor, blockade of Fas-FasL interactions, or interaction of sialylated Fc with a novel macrophage receptor DC-SIGN (Anthony and Ravetch 2010 ). However, these models have never fully accounted for the observed modulation in T cell phenotype upon co-stimulation with IgG and antigen (Kirschbaum et al 2006 ) and the increase of CD4+/CD25+ Tregs after IVIG treatment in skin transplants (Tha-In et al 2010 ) or experimental autoimmune encephalitis (EAE) (Toubi and Etzioni 2005 ). Others have described the immunosuppressive effects of specifi c IgG-derived peptides subsequently identifi ed as Tregitopes Sharabi et al 2006 ;Hahn et al 2005 ), providing…”

Section: Tregitopesmentioning

confidence: 99%

Biobetters

2015

AAPS Advances in the Pharmaceutical Sciences Series

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Modulation of lymphocyte phenotype and function by immunoglobulins

Abstract: Our data demonstrate that, in vitro, immunoglobulins modulate the activation and cytokine production of peripheral blood lymphocytes from both HD and patients with AD.

Cited by 5 publications

References 33 publications

In Vitro and In Vivo Studies of IgG-derived Treg Epitopes (Tregitopes): A Promising New Tool for Tolerance Induction and Treatment of Autoimmunity

In Vitro and In Vivo Studies of IgG-derived Treg Epitopes (Tregitopes): A Promising New Tool for Tolerance Induction and Treatment of Autoimmunity

Activation/modulation of adaptive immunity emerges simultaneously after 17DD yellow fever first-time vaccination: is this the key to prevent severe adverse reactions following immunization?

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