Modulation of Liposomal Membrane Fluidity by Flavonoids and Isoflavonoids

Arora, Arti; Byrem, Todd M.; Nair, Muraleedharan G.; Strasburg, Gale M.

doi:10.1006/abbi.1999.1525

Cited by 531 publications

(345 citation statements)

References 35 publications

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“…Quinic acid is a precursor of the shikimic acid pathway, a common metabolic pathway in the biosynthesis of aromatic amino acids such as tyrosine and phenylalanine (36) that are precursors of flavonoids (37). Their antioxidant capacity results from their high reactivity as H or electron donors (38) and from the role of some compounds (e.g., flavonoids) in altering the kinetics of peroxidation (39). In summer, the drought-treated leaves also had higher concentrations of choline, which is involved in osmotic protection (40).…”

Section: Discussionmentioning

confidence: 99%

Strong relationship between elemental stoichiometry and metabolome in plants

Rivas‐Ubach

Sardans

Pérez‐Trujillo

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

233

209

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Shifts in the elemental stoichiometry of organisms in response to their ontogeny and to changing environmental conditions should be related to metabolomic changes because elements operate mostly as parts of molecular compounds. Here we show this relationship in leaves of Erica multiflora throughout their seasonal development and in response to moderate experimental field conditions of drought and warming. The N/P ratio in leaves decreased in the metabolically active growing seasons, coinciding with an increase in the content of primary metabolites. These results support the growthrate hypothesis that states that rapidly growing organisms present low N/P ratios because of the increase in allocation of P to RNA. The foliar N/K and P/K ratios were lower in summer and in the drought treatment, in accordance with the role of K in osmotic protection, and coincided with the increase of compounds related to the avoidance of water stress. These results provide strong evidence of the relationship between the changes in foliar C/N/P/K stoichiometry and the changes in the leaf's metabolome during plant growth and environmental stress. Thus these results represent a step in understanding the relationships between stoichiometry and an organism's lifestyle.climate change | metabolomics | ecometabolomics | Mediterranean climate

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Section: Discussionmentioning

confidence: 99%

Strong relationship between elemental stoichiometry and metabolome in plants

Rivas‐Ubach

Sardans

Pérez‐Trujillo

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

233

209

View full text Add to dashboard Cite

show abstract

“…Polyphenols can chelate transition metal ions, can directly scavenge molecular species of active oxygen, and can inhibit lipid peroxidation by trapping the lipid alkoxyl radical. They also modify lipid packing order and decrease fluidity of the membranes (Arora et al, 2000). These changes could strictly hinder diffusion of free radicals and restrict peroxidative reactions.…”

Section: Resultsmentioning

confidence: 99%

Alleviation of Cadmium Toxicity in Pisum sativum L. Seedlings by Calcium Chloride

El-Beltagi

Mohamed

2013

Not Bot Hort Agrobot Cluj

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The present investigation was carried out to study the role of calcium chloride in enhancing tolerance and reducing cadmium toxicity in pea seedlings. Some treatment with 1 and 5 mM CaCl 2 mitigated cadmium stress by increasing antioxidant enzyme activities: catalase (CAT), peroxidase (POD) and polyphenol oxidase (PPO), as well as by elevating contents of ascorbic acid (ASA), tocopherol and carotenoids. On the other hand, total carbohydrate and total soluble proteins decreased with increasing cadmium concentrations in comparison with control plants. However, total phenol, total free amino acids, proline and lipid peroxidation increased with increasing concentrations of cadmium acetate. Electrophoretic studies of protein revealed that cadmium treatments alone or in combination with calcium chloride were associated with the disappearance of some bands or appearance of new bands in pea seedlings. Electrophoretic studies of α-esterase, β-esterase and acid phosphatase isozymes showed wide variations in their intensities and densities.

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“…Wei et al (2002) mentions that genistein provides protection against non-ionizing radiation of ultraviolet-B and against reactive oxygen species (ROS), indirectly acting as an anti-inflammatory when genistein was applied to the skin of mice 1 hour before exposure to radiation. Arora et al (2000) found that soy isoflavonoids may inhibit the diffusion of free radicals and lower the reaction kinetics of free radicals thus stabilizing the structure of cell membranes. Damage to normal tissue can be controlled using radioprotective agents.…”

Section: Discussionmentioning

confidence: 99%

Polyherbal EMSA ERITIN Promotes Erythroid Lineages and Lymphocyte Migration in Irradiated Mice

2016

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Radiotherapy is commonly used to kill malignant cells, but it can significantly deplete hematopoietic and splenic erythroblasts. Radioprotective agents are therefore very important in clinical radiotherapy. We examined the effect of poly-herbal EMSA ERITIN on immunological responses when administered to sublethally irradiated mice with the aim of highlighting promotes erythroid lineages and lymphocytes migration in irradiated mice with the parameter are TER119+CD123+in bone marrow and SDF-1 in bone marrow and spleen organ. Normal BALB/c mice were sublethally irradiated with 600 rad. EMSA ERITIN was administered orally at different doses:(1.04, 3.125 and 9.375 mg/g body weight) for 15 days. On day 16 erythroid lineages (TER-119+CD123+) were observed in bone marrow and lymphocytes migration by the production of SDF-1 in spleen and bone marrow. Lymphocytes migration was indicated by the production of SDF-1 in spleen and bone marrow using flow cytometry analysis. EMSA ERITIN increased the generation of erythroid lineage cells marked by TER119+CD123+ and promoted lymphocyte migration by increasing SDF-1 production in bone marrow and spleen. EMSA ERITIN appears to be a powerful medicinal herb with potential as a food supplement to normalize homeostasis and erythropoiesis after radiation.

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Modulation of Liposomal Membrane Fluidity by Flavonoids and Isoflavonoids

Cited by 531 publications

References 35 publications

Strong relationship between elemental stoichiometry and metabolome in plants

Strong relationship between elemental stoichiometry and metabolome in plants

Alleviation of Cadmium Toxicity in Pisum sativum L. Seedlings by Calcium Chloride

Polyherbal EMSA ERITIN Promotes Erythroid Lineages and Lymphocyte Migration in Irradiated Mice

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